// Create by D. Kim in 2012
// pyramidal Cells template
/////////////////////////////
///// Type A cell in LA /////
/////////////////////////////
begintemplate Cell_A
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_A"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.008//0.03
GmC = 0.00055//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_A
///////////////////////////////////////////////////////////
begintemplate Cell_ADA
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_ADA"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.008//0.03
GmC = 0.00055//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_ADA
////////////////////////////////////////////////////////
begintemplate Cell_ANE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_ANE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.008//0.03
GmC = 0.00055//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_ANE
//////////////////////////////////////////////////
begintemplate Cell_ADANE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_ADANE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.008//0.03
GmC = 0.00055//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_ADANE
/////////////////////////////
///// Type B cell in LA /////
/////////////////////////////
begintemplate Cell_B
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_B"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00045
GmC = 0.00039
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
//insert hd ghdbar_hd=1.35758E-07 vhalfl_hd=-73
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_B
////////////////////////////////////////////////
begintemplate Cell_BDA
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_BDA"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00045
GmC = 0.00039
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP //2.3181e-05
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_BDA
//////////////////////////////////////////////////
begintemplate Cell_BNE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_BNE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00045
GmC = 0.00039
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP //0.008968224 //0.00015 //2.3181e-05
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP //2.3181e-05
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_BNE
/////////////////////////////////////////////////////////
begintemplate Cell_BDANE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_BDANE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00045
GmC = 0.00039
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP //0.008968224 //0.00015 //2.3181e-05
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP //2.3181e-05
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_BDANE
/////////////////////////////
///// Type C cell in LA /////
/////////////////////////////
begintemplate Cell_C
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_C"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00036//0.03
GmC = 0.0004//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP //2.3181e-05
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_C
/////////////////////////////////////////////////
begintemplate Cell_CDA
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_CDA"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00036//0.03
GmC = 0.0004//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
//insert hd ghdbar_hd=1.35758E-07 vhalfl_hd=-73 // changed from - 73 mV
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHP gsAHPbar_sAHP = gsAHP //2.3181e-05
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_CDA
/////////////////////////////////////////////////
begintemplate Cell_CNE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_CNE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00036//0.03
GmC = 0.0004//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
//insert cal gcalbar_cal = 0.005 /*decreased from 0.003 */
}
p_dend {
insert leak el_leak=Vpas glbar_leak = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
//insert hd ghdbar_hd=1.35758E-07 vhalfl_hd=-73 // changed from - 73 mV
insert na3 gbar_na3=1.9798*gna sh_na3=nash ar_na3=1
insert kdr gkdrbar_kdr=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leak el_leak=Vpas glbar_leak = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leak el_leak=Vpas glbar_leak = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3 sh_na3=nash ar_na3=1 gbar_na3=gna
insert kdr gkdrbar_kdr=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_CNE
//////////////////////////////////////////////
begintemplate Cell_CDANE
public soma, dend, p_dend, connect2target, type
create soma, dend, p_dend
public ncl, synlist
objref ncl, synlist
strdef type
proc init() {
ncl = new List()
synlist =new List()
type = "Cell_CDANE"
gUnf_Xsoma = 2.5e-05
Rm = 80000 // decreased overall
SpineScale = 1.76371308
SpineScale_leak = 1.763714578
Cm = 1.4
RaAll= 200
RaSoma= 146.969697
RaAxIs = 100
Vpas = -70 // -67
gna = .03*0.6*1.5 /* decreased from 0.03 */
AXONM = 3 /*decrease from 2 */
gkdr = 0.005*.6 /* decreased from 0.005 */
KMULT = 0.022*.65 /* decreased from 0.022 */
KMULTP = 0.022*.65 /* decreased from 0.022 */
ghd=0.000003 *.7
nash=10
Vrest = -70
celsius = 31.0
gsAHP = 0.00036//0.03
GmC = 0.0004//0.062//0.07
Diameter = 5
/////// topology ////////
create soma, dend
connect dend(0), soma(0)
connect p_dend(0), soma(1)
/////// geometry ////////
soma {L = 25 diam = 24.75 nseg = 1} //{L = 20 diam = 20 nseg = 13}
dend {diam=2.5 L=296.25/diam nseg=1}
p_dend {diam = Diameter L = 2000/diam nseg=1} //
access soma
distance()
forall {
insert cadyn gcabar_cadyn = 2e-4 eca = 120
//insert cal gcalbar_cal = 0.005 /*decreased from 0.003 */
}
p_dend {
insert leakDA el_leakDA=Vpas glbar_leakDA = 2.4444e-5*3 Ra=RaAll cm=Cm*1.98285453
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = 0.4*gsAHP
insert im gmbar_im = GmC
v=Vrest
}
soma {
insert na3DA gbar_na3DA=1.9798*gna sh_na3DA=nash ar_na3DA=1
insert kdrDA gkdrbar_kdrDA=gkdr
insert kap gkabar_kap = KMULTP*0.1
insert im gmbar_im = GmC
insert leakDA el_leakDA=Vpas glbar_leakDA = 1/Rm Ra=RaSoma cm=Cm
}
dend { // need to add Spine Scale
insert leakDA el_leakDA=Vpas glbar_leakDA = SpineScale_leak*1/Rm*1.5 Ra=RaAll cm=Cm*SpineScale //1.9804/Rm
insert hd ghdbar_hd=2.85995e-05 vhalfl_hd=-78.72884325 //ghd
insert na3DA sh_na3DA=nash ar_na3DA=1 gbar_na3DA=gna
insert kdrDA gkdrbar_kdrDA=gkdr
insert kad gkabar_kad=0.031913796*0.1
insert capool taucas = 1000 fcas_capool = 0.05
insert sAHPNE gsAHPbar_sAHPNE = gsAHP
insert im gmbar_im = GmC
}
forall {
v=Vrest
ena = 45
ek = -80
if (ismembrane("kdrDA") || ismembrane("kap") || ismembrane("kad")) {ek=-80}
if (ismembrane("hd") ) {ehd_hd=-43 } // change from -30 to -50
}
}
obfunc connect2target() { localobj nc
soma nc = new NetCon(&v(0.5), $o1)
nc.threshold = 0
if (numarg() == 2) ($o2 = nc)
return nc
}
endtemplate Cell_CDANE