: voltage-gated persistent muscarinic channel
NEURON {
SUFFIX im
USEION k READ ek WRITE ik
RANGE gmbar, gm
RANGE inf, tau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gmbar = 0.0003 (siemens/cm2) <0,1e9>
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
inf
tau (ms)
gm (siemens/cm2)
}
STATE {
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
gm = gmbar*n*n
ik = gm*(v-ek)
}
INITIAL {
rate(v)
n = inf
}
DERIVATIVE states {
rate(v)
n' = (inf-n)/tau
}
FUNCTION alf(v (mV)) (/ms) {
UNITSOFF
alf = 0.016/exp(-(v+52.7)/23)
UNITSON
}
FUNCTION bet(v (mV)) (/ms) {
UNITSOFF
bet = 0.016/exp((v+52.7)/18.8)
UNITSON
}
PROCEDURE rate(v (mV)) {
LOCAL sum, aa, ab
UNITSOFF
aa=alf(v) ab=bet(v)
sum = aa+ab
inf = aa/sum
tau = 1/sum
UNITSON
}