: passive leak current
NEURON {
SUFFIX leakDA
NONSPECIFIC_CURRENT il
RANGE il, el, glbar
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
tone_period = 4000
DA_period = 500
DA_start = 36000 : D2R(High Affinity) Dopamine Effect after 6 conditioning trials (15*4000) = 60000)
DA_stop = 96000
DA_ext1 = 196000
DA_ext2 = 212000
DA_t1 = 0.8 : 0.9 : 1 : 1 : 0.9 : Amount(%) of DA effect- negative value decreases AP threshold / positive value increases threshold of AP
DA_period2 = 100
DA_start2 = 36000 : shock Dopamine Effect during shock after 1 conditioning trial
DA_t2 = .9 : Amount(%) of DA effect- negative value decreases AP threshold / positive value increases threshold of AP
glbar = 2.857142857142857e-05 :3.333333e-5 (siemens/cm2) < 0, 1e9 >
el = -75 (mV)
}
ASSIGNED {
v (mV)
il (mA/cm2)
}
BREAKPOINT {
il = glbar*(v - el)*DA1(t)*DA2(t)
}
FUNCTION DA1(t) {
if (t >= DA_start && t <= DA_stop){ : During conditioning
if ((t/tone_period-floor(t/tone_period)) >= (1-DA_period/tone_period)) {DA1 = DA_t1}
else if ((t/tone_period-floor(t/tone_period)) == 0) {DA1 = DA_t1}
else {DA1 = 1}}
else if (t >= DA_ext1 && t <= DA_ext2){ : During 4trials of Extinction
if ((t/tone_period-floor(t/tone_period)) >= (1-DA_period/tone_period)) {DA1 = DA_t1}
else if ((t/tone_period-floor(t/tone_period)) == 0) {DA1 = DA_t1}
else {DA1 = 1}}
else {DA1 = 1}
}
FUNCTION DA2(t) {
if (t >= DA_start2 && t <= DA_stop){
if((t/tone_period-floor(t/tone_period)) >= (1-DA_period2/tone_period)) {DA2 = DA_t2}
else if ((t/tone_period-floor(t/tone_period)) == 0) {DA2 = DA_t2}
else {DA2 = 1}}
else {DA2 = 1}
}