: spike-generating sodium channel (interneuron)
NEURON {
SUFFIX nainter
USEION na READ ena WRITE ina
RANGE gnabar, ina, gnaer
RANGE minf, hinf, mtau, htau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
dt (ms)
gnabar = 0.035 (mho/cm2) <0,1e9>
ena = 45 (mV)
}
STATE {
m h
}
ASSIGNED {
ina (mA/cm2)
minf hinf
mtau (ms)
htau (ms)
gna (mho/cm2)
}
INITIAL {
rate(v)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gna = gnabar*m*m*m*h
ina = gna*(v-ena)
}
DERIVATIVE states {
rate(v)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
}
UNITSOFF
FUNCTION malf(v(mV)) {
malf = 2.1*exp((v+18.5)/11.75) :malf = 2.1*exp((v+18.5)/11.57)
}
FUNCTION mbet(v(mV)) {
mbet = 2.1*exp(-(v+18.5)/27)
}
FUNCTION half(v(mV)) {
half = 0.045*exp(-(v+29)/33)
}
FUNCTION hbet(v(mV)) {
hbet = 0.045*exp((v+29)/12.2)
}
PROCEDURE rate(v(mV)) { LOCAL msum, hsum, ma, mb, ha, hb
ma = malf(v) mb = mbet(v) ha = half(v) hb = hbet(v)
msum = ma+mb
minf = ma/msum
mtau = 1/(msum)
hsum = ha+hb
hinf = ha/hsum
htau = 1/(hsum)
}
UNITSON