: iC fast Ca2+/V-dependent K+ channel
NEURON {
SUFFIX sAHP
USEION k READ ek WRITE ik
USEION cas READ casi VALENCE 2
RANGE ik, gk, gsAHPbar
}
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gsAHPbar= 2.318144e-05 : 0.0001 (mho/cm2) :
}
ASSIGNED {
v (mV)
ek (mV)
casi (mM)
ik (mA/cm2)
cinf
ctau (ms)
gk (mho/cm2)
}
STATE {
c
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk = gsAHPbar*c
ik = gk*(v-ek)
}
INITIAL {
rate(v,casi)
c = cinf
}
DERIVATIVE states {
rate(v,casi)
c' = (cinf-c)/ctau
}
UNITSOFF
FUNCTION calf(v (mV), casi (mM)) (/ms) { LOCAL vs, va
UNITSOFF
vs=10*log10(1000*casi)
calf = 0.0048/exp(-0.5*(vs-35))
UNITSON
}
FUNCTION cbet(v (mV), casi (mM))(/ms) { LOCAL vs, vb
UNITSOFF
vs=10*log10(1000*casi)
cbet = 0.012/exp(0.2*(vs+100))
UNITSON
}
UNITSON
PROCEDURE rate(v (mV), casi (mM)) {LOCAL csum, ca, cb
UNITSOFF
ca=calf(v, casi)
cb=cbet(v, casi)
csum = ca+cb
cinf = ca/csum
ctau = 48
UNITSON
}