# Load in the goods
import numpy as np
import sys
from scipy.io import savemat
from math import nan
# parse cmd line inputs, load PT cell template
## load cell
from getCells import KoleCell
pt_cell = KoleCell()
## specify stimulated section and soma segment
section = sys.argv[-1]
if section.split('.')[1][:4] == 'apic':
stim_sec = pt_cell.apic[int(section.split('.')[1].split('[')[1].split(']')[0])]
else:
stim_sec = pt_cell.dend[int(section.split('.')[1].split('[')[1].split(']')[0])]
soma_seg = pt_cell.soma(0.5)
## specify factors to change gbar ih/im by, ih comes first
if sys.argv[-3][0] == 'm':
ih_factor = -0.15
else:
ih_factor = float(sys.argv[-3])
if sys.argv[-2][0] == 'm':
im_factor = -0.15
else:
im_factor = float(sys.argv[-2])
# changes to Im/Ih
## determine original values
orig_km = []
orig_ih = []
for sec in pt_cell.all:
for seg in sec.allseg():
try:
orig_km.append(seg.Km.gbar)
except:
orig_km.append(0)
try:
orig_ih.append(seg.ih.ghdbar)
except:
orig_ih.append(0)
## change Ih/Im
count = 0
for sec in pt_cell.all:
for seg in sec.allseg():
try:
seg.Km.gbar = orig_km[count] + im_factor * orig_km[count]
except:
pass
try:
seg.ih.ghdbar = orig_ih[count] + ih_factor * orig_ih[count]
except:
pass
count = count + 1
# define current stimulus
from chirpUtils import applyChirp
from chirpUtils import getChirp
amp = 0.0025
f0, f1, t0, Fs, delay = 0.5, 50, 50, 1000, 12
I, t = getChirp(f0, f1, t0, amp, Fs, delay)
# define output variables
ZinResAmp = []
ZinResFreq = []
ZcResAmp = []
ZcResFreq = []
dist = []
QfactorIn = []
QfactorTrans = []
fVarIn = []
fVarTrans = []
ZinPeakPhaseFreq = []
ZinLeadPhaseBW = []
ZinLeadPhaseMinFreq = []
ZinSynchFreq = []
ZinLeadPhaseBool = []
ZcPeakPhaseFreq = []
ZcLeadPhaseBW = []
ZcLeadPhaseMinFreq = []
ZcSynchFreq = []
ZcLeadPhaseBool = []
# main loop
nseg = stim_sec.nseg
if nseg == 1:
loc = 0.5
out = applyChirp(I, t, stim_sec(loc), soma_seg, t0, delay, Fs, f1)
ZinResAmp.append(out['ZinResAmp'])
ZinResFreq.append(out['ZinResFreq'])
ZcResAmp.append(out['ZcResAmp'])
ZcResFreq.append(out['ZcResFreq'])
dist.append(out['dist'])
QfactorIn.append(out['QfactorIn'])
QfactorTrans.append(out['QfactorTrans'])
fVarIn.append(out['fVarIn'])
fVarTrans.append(out['fVarTrans'])
freqs = out['Freq'][np.argwhere(out['ZinPhase'] > 0)]
if len(freqs) > 0:
ZinPeakPhaseFreq.append(out['Freq'][np.argwhere(out['ZinPhase'] == np.max(out['ZinPhase']))])
ZinLeadPhaseBW.append(freqs[-1] - freqs[0])
ZinLeadPhaseMinFreq.append(freqs[0])
ZinSynchFreq.append(freqs[-1])
ZinLeadPhaseBool.append(out['ZinPhase'] > 0)
else:
ZinPeakPhaseFreq.append(nan)
ZinLeadPhaseBW.append(0)
ZinLeadPhaseMinFreq.append(nan)
ZinSynchFreq.append(nan)
ZinLeadPhaseBool.append(out['ZinPhase'] > 0)
freqs = out['Freq'][np.argwhere(out['ZcPhase'] > 0)]
if len(freqs) > 0:
ZcPeakPhaseFreq.append(out['Freq'][np.argwhere(out['ZcPhase'] == np.max(out['ZcPhase']))])
ZcLeadPhaseBW.append(freqs[-1] - freqs[0])
ZcLeadPhaseMinFreq.append(freqs[0])
ZcSynchFreq.append(freqs[-1])
ZcLeadPhaseBool.append(out['ZcPhase'])
else:
ZcPeakPhaseFreq.append(nan)
ZcLeadPhaseBW.append(0)
ZcLeadPhaseMinFreq.append(nan)
ZcSynchFreq.append(nan)
ZcLeadPhaseBool.append(out['ZcPhase'])
print(str(sec) + ' ' + str(loc))
else:
for loc in np.linspace(1/(nseg+1), nseg/(nseg+1), nseg):
out = applyChirp(I, t, stim_sec(loc), soma_seg, t0, delay, Fs, f1)
ZinResAmp.append(out['ZinResAmp'])
ZinResFreq.append(out['ZinResFreq'])
ZcResAmp.append(out['ZcResAmp'])
ZcResFreq.append(out['ZcResFreq'])
dist.append(out['dist'])
QfactorIn.append(out['QfactorIn'])
QfactorTrans.append(out['QfactorTrans'])
fVarIn.append(out['fVarIn'])
fVarTrans.append(out['fVarTrans'])
freqs = out['Freq'][np.argwhere(out['ZinPhase'] > 0)]
if len(freqs) > 0:
ZinPeakPhaseFreq.append(out['Freq'][np.argwhere(out['ZinPhase'] == np.max(out['ZinPhase']))])
ZinLeadPhaseBW.append(freqs[-1] - freqs[0])
ZinLeadPhaseMinFreq.append(freqs[0])
ZinSynchFreq.append(freqs[-1])
ZinLeadPhaseBool.append(out['ZinPhase'] > 0)
else:
ZinPeakPhaseFreq.append(nan)
ZinLeadPhaseBW.append(0)
ZinLeadPhaseMinFreq.append(nan)
ZinSynchFreq.append(nan)
ZinLeadPhaseBool.append(out['ZinPhase'] > 0)
freqs = out['Freq'][np.argwhere(out['ZcPhase'] > 0)]
if len(freqs) > 0:
ZcPeakPhaseFreq.append(out['Freq'][np.argwhere(out['ZcPhase'] == np.max(out['ZcPhase']))])
ZcLeadPhaseBW.append(freqs[-1] - freqs[0])
ZcLeadPhaseMinFreq.append(freqs[0])
ZcSynchFreq.append(freqs[-1])
ZcLeadPhaseBool.append(out['ZcPhase'])
else:
ZcPeakPhaseFreq.append(nan)
ZcLeadPhaseBW.append(0)
ZcLeadPhaseMinFreq.append(nan)
ZcSynchFreq.append(nan)
ZcLeadPhaseBool.append(out['ZcPhase'])
output = { 'ZinResAmp' : ZinResAmp,
'ZinResFreq' : ZinResFreq,
'ZcResAmp' : ZcResAmp,
'ZcResFreq' : ZcResFreq,
'dist' : dist,
'QfactorIn' : QfactorIn,
'QfactorTrans' : QfactorTrans,
'fVarIn' : fVarIn,
'fVarTrans' : fVarTrans,
'ZinPeakPhaseFreq' : ZinPeakPhaseFreq,
'ZinLeadPhaseBW' : ZinLeadPhaseBW,
'ZinLeadPhaseMinFreq' : ZinLeadPhaseMinFreq,
'ZinSynchFreq' : ZinSynchFreq,
'ZinLeadPhaseBool' : ZinLeadPhaseBool,
'ZcPeakPhaseFreq' : ZcPeakPhaseFreq,
'ZcLeadPhaseBW' : ZcLeadPhaseBW,
'ZcLeadPhaseMinFreq' : ZcLeadPhaseMinFreq,
'ZcSynchFreq' : ZcSynchFreq,
'ZcLeadPhaseBool' : ZcLeadPhaseBool}
savemat('/home/craig_kelley_downstate_edu/L5PYR_Resonance/Kole/Vary_Global_Gs/ih_' + sys.argv[-3] + '_im_' + sys.argv[-2] + '/' + stim_sec.name() + '.mat', output)