: From 'Dentate gyrus network model' (Santhakumar et al 2005) https://senselab.med.yale.edu/ModelDB/ShowModel?model=51781&file=/dentategyrusnet2005/ccanl.mod#tabs-1
COMMENT
calcium accumulation into a volume of area*depth next to the
membrane with a decay (time constant tau) to resting level
given by the global calcium variable cai0_ca_ion
ENDCOMMENT
NEURON {
SUFFIX cdp5r
USEION ca WRITE cai
USEION nca READ inca WRITE ncai VALENCE 2
USEION lca READ ilca WRITE lcai VALENCE 2 :eg
USEION tca READ itca WRITE tcai VALENCE 2
RANGE caiinf, caitot, ncai, lcai,tcai, ecatot, elca, enca, etca,cai
GLOBAL catau
}
UNITS {
(mV) = (millivolt)
(molar) = (1/liter)
(mM) = (milli/liter)
(mA) = (milliamp)
FARADAY = 96520 (coul)
R = 8.3134 (joule/degC)
}
INDEPENDENT {t FROM 0 TO 100 WITH 100 (ms)}
PARAMETER {
celsius = 6.3 (degC)
depth = 200 (nm) : assume volume = area*depth
catau = 0.1 (ms)
caiinf = 50.e-6 (mM) : takes precedence over cai0_ca_ion
: Do not forget to initialize in hoc if different
: from this default.
caotot = 2 (mM)
ica (mA/cm2)
inca (mA/cm2)
ilca (mA/cm2)
itca (mA/cm2)
caitot= 50.e-6 (mM)
:cai= 50.e-6 :eg
n_ions=3
}
ASSIGNED {
enca (mV)
elca (mV)
etca (mV)
ecatot (mV)
}
STATE {
ncai (mM)
lcai (mM)
tcai (mM)
cai (mM)
}
INITIAL {
cai= 50.e-6
VERBATIM
ncai = _ion_ncai;
tcai = _ion_tcai;
lcai = _ion_lcai;
ENDVERBATIM
ncai=caiinf/n_ions
lcai=caiinf/n_ions
tcai=caiinf/n_ions
:caitot = caiinf
cai = caiinf
ecatot = ktf() * log(caotot/caiinf)
enca = ecatot
elca = ecatot
etca = ecatot
}
BREAKPOINT {
SOLVE integrate METHOD derivimplicit
:caitot = ncai+lcai+tcai
cai = ncai+tcai+lcai
:ecatot = ktf() * log(caotot/caitot)
ecatot = ktf() * log(caotot/caiinf)
enca = ecatot
:elca = ecatot
etca = ecatot
}
DERIVATIVE integrate {
ncai' = -(inca)/depth/FARADAY * (1e7) + (caiinf/n_ions - ncai)/catau
lcai' = -(ilca)/depth/FARADAY * (1e7) + (caiinf/n_ions - lcai)/catau
tcai' = -(itca)/depth/FARADAY * (1e7) + (caiinf/n_ions - tcai)/catau
cai'= -(ilca+inca+itca)/depth/FARADAY * (1e7) + (caiinf -cai)/catau
}
FUNCTION ktf() (mV) {
ktf = (1000)*R*(celsius +273.15)/(2*FARADAY)
}