Author: Etay Hay, 2011 Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties (Hay et al., PLoS Computational Biology, 2011) NEURON models and model sets corresponding to the paper: Demo: Either auto-launch from ModelDB or download and extract the archive and compile the mod files (with mknrndll (mswin and mac, or nrnivmodl (linux/unix)) and then start the simulation by the file init.hoc. Once the simulation is started select a button to re-create parts of Figure 4 from the paper. Clicking on the Fig. 4A should create an image like: Likewise the Fig 4B, Fig 5A buttons should create images like these: Additional information: folder: models ============== NEURON code models, shown in various figures L5PCbiophys1 - figure 1 (constrained only for BAC firing) L5PCbiophys2 - figure 2 (constrained only for current step firing) L5PCbiophys3 - figure 4 (constrained both for BAC and current step firing) L5PCbiophys4 - figure S5 (AP initiation at the axon) L5PCtemplate - general cell template folder: simulation code ======================= simulation code for BAC firing or step current firing. folder: model sets ================== model sets corresponding to various figures. models_errors file: error values matrix (rows: models; columns: objectives) models_parameters file: parameter values matrix (rows: models; columns: parameters) objetives file: objective names, each corresponding to a column in models_errors file genome file: parameter names and search limits, each corresponding to a column in the models_parameters file folder: mechanisms ================== mod files of the conductance mechanisms used. folder: morphologies ==================== The three morphologies used in the paper. 20130226 added critical_frequency.hoc to simulationcode folder 20130330 critical_frequency.hoc file updated with a comment regarding a difference between 32 and 64 bit NEURON environments.