TITLE HH_Kdr35 channel for LGMD
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
NEURON {
SUFFIX HH_Kdr35
USEION k READ ek WRITE ik
RANGE gmax, gk
}
PARAMETER {
gmax= 0.018 (mho/cm2)
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
nalpha (/ms)
nbeta (/ms)
gk (mS/cm2)
}
STATE {
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk = gmax*n*n*n*n
ik = gmax*n*n*n*n*(v-ek)
}
INITIAL {
settables(v)
n = nalpha/(nalpha+nbeta)
}
DERIVATIVE states {
settables(v)
n' = 4*((nalpha*(1-n)) - (nbeta*n))
}
UNITSOFF
PROCEDURE settables(v (mV)) {
LOCAL den, n_sf, npos
TABLE nalpha, nbeta
FROM -100 TO 100 WITH 2000
n_sf = 3.5
npos = 34
den = (exp(-0.1*(v+npos))-1)
if (v > (-npos-.5) && v < (-npos+.5)) {
nalpha = n_sf*0.1
} else {
nalpha = n_sf*(-0.01*(v+npos))/den
}
nbeta = n_sf*0.125*exp(-(v+npos+10)/25)
}
UNITSON