//genesis if (!({exists /library/mGABA})) create channelC2 /library/mGABA end // sec // sec // Siemens setfield /library/mGABA Ek {EK} tau1 4e-3 tau2 4e-3 \ gmax {GMAX_K} if (!({exists /library/mglu})) create channelC2 /library/mglu end // sec // sec // Siemens setfield /library/mglu Ek {ENA} tau1 2e-3 tau2 2e-3 \ gmax {DISTAL_GMAX_NA} if (!({exists /library/gglu})) create channelC2 /library/gglu end // sec // sec // Siemens setfield /library/gglu Ek {ENA} tau1 2e-3 tau2 2e-3 \ gmax {DISTAL_GMAX_NA} if (!({exists /library/aspike})) create spike /library/aspike // V // sec setfield /library/aspike thresh -0.01 abs_refract 0.01 \ output_amp 1 create axon /library/aspike/axon addmsg /library/aspike /library/aspike/axon BUFFER name end if (!({exists /library/term})) create channelA /library/term // Seimens // V setfield /library/term Gk 5e-9 Ek 1.0 end // See mit definition file EREST_ACT = -0.065 /* Adjusting the EREST dependent terms to fit with rest pot of cell */ // V // V // V // V setfield /library/MHH_Na_channel X_alpha_V0 {0.013 + {EREST_ACT}} \ X_beta_V0 {40.0e-3 + {EREST_ACT}} Y_alpha_V0 {0.017 + {EREST_ACT}} \ Y_beta_V0 {40.0e-3 + {EREST_ACT}} // V // V setfield /library/MHH_K_channel X_alpha_V0 {0.015 + {EREST_ACT}} \ X_beta_V0 {0.010 + {EREST_ACT}} // See gran definition file EREST_ACT = -0.06 /* Adjusting the EREST dependent terms to fit with rest pot of cell */ // V // V // V // V setfield /library/GHH_Na_channel X_alpha_V0 {0.023 + {EREST_ACT}} \ X_beta_V0 {50.0e-3 + {EREST_ACT}} Y_alpha_V0 {0.027 + {EREST_ACT}} \ Y_beta_V0 {50.0e-3 + {EREST_ACT}} // V // V setfield /library/GHH_K_channel X_alpha_V0 {0.025 + {EREST_ACT}} \ X_beta_V0 {0.020 + {EREST_ACT}} if (!({exists /library/YCa})) int ndivs create vdep_channel /library/YCa // V // S setfield /library/YCa Ek {ECA_ACT} gbar {200*{SOMA_A}} create tabgate /library/YCa/mgate call /library/YCa/mgate TABCREATE alpha 100 -0.2 0.1 call /library/YCa/mgate TABCREATE beta 100 -0.2 0.1 x = get(/library/YCa/mgate,alpha->xmin) dx = get(/library/YCa/mgate,alpha->dx) ndivs = {getfield /library/YCa/mgate alpha->xdivs} // Mit definitions EREST_ACT = -0.065 int i for (i = 0; i <= ndivs; i = i + 1) if ({x} < -0.032) setfield /library/YCa/mgate \ alpha->table[{i}] 0.0 y = (exp({({x} + 0.006 - {EREST_ACT})/0.016}) + \ exp({-({x} + 0.006 - {EREST_ACT})/0.016})) / \ 7.8e-3 setfield /library/YCa/mgate beta->table[{i}] {y} else y = (exp({({x} + 0.006 - {EREST_ACT})/0.016}) + \ exp({-({x} + 0.006 - {EREST_ACT})/0.016})) / \ (7.8e-3 * (1.0 + \ exp({-({x} - 0.003 - {EREST_ACT})/0.008}))) setfield /library/YCa/mgate \ alpha->table[{i}] {y} y = (exp({({x} + 0.006 - {EREST_ACT})/0.016}) + \ exp({-({x} + 0.006 - {EREST_ACT})/0.016})) / \ 7.8e-3 * (1.0 - 1.0 / (1.0 + \ exp({-({x} - 0.003 - {EREST_ACT})/0.008}))) setfield /library/YCa/mgate beta->table[{i}] {y} end x = x + dx end create table /library/YCa/hgate call /library/YCa/hgate TABCREATE 100 0.0 1.0 x = get(/library/YCa/hgate,table->xmin) dx = get(/library/YCa/hgate,table->dx) ndivs = {getfield /library/YCa/hgate table->xdivs} for (i = 0; i <= ndivs; i = i + 1) y = 0.01/(0.01 + x) setfield /library/YCa/hgate table->table[{i}] {y} x = x + dx end create table /library/YCa/nernst call /library/YCa/nernst TABCREATE 1000 0.00005 0.01 x = get(/library/YCa/nernst,table->xmin) dx = get(/library/YCa/nernst,table->dx) ndivs = {getfield /library/YCa/nernst table->xdivs} for (i = 0; i <= ndivs; i = i + 1) y = 12.5e-3 * log({4.0/{x}}) setfield /library/YCa/nernst table->table[{i}] {y} x = x + dx end create Ca_concen /library/YCa/conc // sec // Moles per coulomb, later scaled to conc // Moles per cubic m setfield /library/YCa/conc tau 0.00001 B 5.2e-6 Ca_base 1.0e-4 addmsg /library/YCa /library/YCa/conc I_Ca Ik addmsg /library/YCa/conc /library/YCa/nernst INPUT Ca addmsg /library/YCa/conc /library/YCa/hgate INPUT Ca addmsg /library/YCa/nernst /library/YCa EK output addmsg /library/YCa/hgate /library/YCa MULTGATE output 1 addmsg /library/YCa/mgate /library/YCa MULTGATE m 1 end