COMMENT
T-type Ca channel
ca.mod to lead to thalamic ca current inspired by destexhe and huguenrd
Uses fixed eca instead of GHK eqn
changed from (AS Oct0899)
changed for use with Ri18 (B.Kampa 2005)
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX it
USEION ca READ eca WRITE ica
RANGE m, h, gca, gbar
RANGE minf, hinf, mtau, htau, inactF, actF
GLOBAL vshift,vmin,vmax, v12m, v12h, vwm, vwh, am, ah, vm1, vm2, vh1, vh2, wm1, wm2, wh1, wh2
}
PARAMETER {
gbar = 0.0008 (mho/cm2) : 0.12 mho/cm2
vshift = 0 (mV) : voltage shift (affects all)
cao = 2.5 (mM) : external ca concentration
cai (mM)
v (mV)
dt (ms)
celsius (degC)
vmin = -120 (mV)
vmax = 100 (mV)
v12m=50 (mV)
v12h=78 (mV)
vwm =7.4 (mV)
vwh=5.0 (mV)
am=3 (mV)
ah=85 (mV)
vm1=25 (mV)
vm2=100 (mV)
vh1=46 (mV)
vh2=405 (mV)
wm1=20 (mV)
wm2=15 (mV)
wh1=4 (mV)
wh2=50 (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
FARADAY = (faraday) (coulomb)
R = (k-mole) (joule/degC)
PI = (pi) (1)
}
ASSIGNED {
ica (mA/cm2)
gca (pS/um2)
eca (mV)
minf hinf
mtau (ms) htau (ms)
tadj
}
STATE { m h }
INITIAL {
trates(v+vshift)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE states
gca = gbar*m*m*h
ica = gca * (v - eca)
}
LOCAL mexp, hexp
PROCEDURE states() {
trates(v+vshift)
m = m + mexp*(minf-m)
h = h + hexp*(hinf-h)
VERBATIM
return 0;
ENDVERBATIM
}
PROCEDURE trates(v) {
LOCAL tinc
TABLE minf, mexp, hinf, hexp
DEPEND dt
FROM vmin TO vmax WITH 199
rates(v): not consistently executed from here if usetable == 1
tinc = -dt
mexp = 1 - exp(tinc/mtau)
hexp = 1 - exp(tinc/htau)
}
PROCEDURE rates(v_) {
LOCAL a, b
minf = 1.0 / ( 1 + exp(-(v_+v12m)/vwm) )
hinf = 1.0 / ( 1 + exp((v_+v12h)/vwh) )
mtau = ( am + 1.0 / ( exp((v_+vm1)/wm1) + exp(-(v_+vm2)/wm2) ) )
htau = ( ah + 1.0 / ( exp((v_+vh1)/wh1) + exp(-(v_+vh2)/wh2) ) )
}