COMMENT
//****************************//
// Created by Alon Polsky //
// apmega@yahoo.com //
// 2010 //
//****************************//
based on Sun et al 2006
ENDCOMMENT
TITLE GABAA synapse
NEURON {
POINT_PROCESS gaba
NONSPECIFIC_CURRENT i
RANGE e ,gmax,local_v,i
RANGE del,Tspike,Nspike
RANGE taudgaba,dgaba,decaygaba
RANGE R,D
GLOBAL risetime,decaytime
}
PARAMETER {
gmax=.5 (nS)
e= -70.0 (mV)
risetime=1 (ms) :2
decaytime=20(ms) :40
v (mV)
del=30 (ms)
Tspike=10 (ms)
Nspike=1
taudgaba=200 (ms)
decaygaba=0.6
}
ASSIGNED {
i (nA)
local_v (mV):local voltage
}
STATE {
dgaba
R
D
}
INITIAL {
dgaba=1
R=0
D=0
}
BREAKPOINT {
LOCAL count
SOLVE state METHOD cnexp
FROM count=0 TO Nspike-1 {
IF(at_time(count*Tspike+del)){
state_discontinuity( R, R+ gmax*dgaba)
state_discontinuity( D, D+ gmax*dgaba)
state_discontinuity( dgaba, dgaba* decaygaba)
}
}
i= (D-R)*(1e-3)* (v- e)
:i= (1e-3)*ggaba* (v- e)
local_v=v
}
DERIVATIVE state {
R'=-R/risetime
D'=-D/decaytime
dgaba'=(1-dgaba)/taudgaba
}