:Tracking intracellular Na and K concentration
: transmembrane Na+ and K+ flux
:Longitudinal diffusion of Na+ and K+ to adjacent compartments (no buffering)
:(equivalent modified euler with standard method and
:equivalent to diagonalized linear solver with CVODE )
: Adapted from Fleidervish 2010
NEURON {
SUFFIX ioni
USEION na READ ina WRITE nai
USEION k READ ik WRITE ki
RANGE D
}
UNITS {
(mM) = (milli/liter)
(um) = (micron)
FARADAY = (faraday) (coulomb)
PI = (pi) (1)
}
PARAMETER {
D = .6 (um2/ms)
}
ASSIGNED {
ina (milliamp/cm2)
ik (milliamp/cm2)
diam (um)
}
STATE {
nai (mM)
ki (mM)
}
BREAKPOINT {
SOLVE conc METHOD sparse
}
KINETIC conc {
COMPARTMENT PI*diam*diam/4 {nai ki}
LONGITUDINAL_DIFFUSION D*PI*diam*diam/4 {nai ki}
~ nai << (-ina/(FARADAY)*PI*diam*(1e4))
~ ki << (-ik/(FARADAY)*PI*diam*(1e4))
}