proc celldef() {
topol()
subsets()
geom()
biophys()
geom_nseg()
}
create mid, siz, trsd, cndt
proc topol() { local i
connect siz(0), mid(1)
connect trsd(0), mid(0)
connect cndt(0), siz(1)
basic_shape()
}
proc basic_shape() {
mid {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(15, 0, 0, 1)}
siz {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(135, 0, 0, 1)}
trsd {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-164, 0, 0, 1)}
cndt {pt3dclear() pt3dadd(135, 0, 0, 1) pt3dadd(210, 0, 0, 1)}
}
objref all, has_ms, no_ms
proc subsets() { local i
objref all, has_ms, no_ms
all = new SectionList()
mid all.append()
siz all.append()
trsd all.append()
cndt all.append()
has_ms = new SectionList()
mid has_ms.append()
trsd has_ms.append()
no_ms = new SectionList()
siz no_ms.append()
}
proc geom() {
mid { L = 6 diam = 0.8 }
siz { L = 6 diam = 0.8 }
trsd { L = 100 diam = 0.8 }
cndt { L = 30 diam = 0.8 }
}
proc geom_nseg() {
mid { nseg = 5 }
siz { nseg = 5 }
trsd { nseg = 10 }
cndt { nseg = 3 }
}
proc biophys() {
forsec all {
Ra = 123
cm = 1
insert nakpump
Imax_nakpump = 0.25
Km_nai_nakpump = 13
Km_ko_nakpump = 1.5
insert nakpas
gbar_nakpas = 0.0001
epas_nakpas = -59
insert ioni
D_ioni = 0.6
}
mid {
insert kf_a
insert kf_d
insert ks
insert nav1p6
epsilon_nav1p6=1.75
zeta_nav1p6=0.6
Q10f_nav1p6 = 1.5
Q10b_nav1p6 = 1.5
insert nav1p7
insert nav1p8
insert nav1p9
}
siz {
insert kf_a
insert kf_d
insert ks
insert nav1p6
epsilon_nav1p6=1.75
zeta_nav1p6=0.6
Q10f_nav1p6 = 1.5
Q10b_nav1p6 = 1.5
insert nav1p7
insert nav1p8
insert nav1p9
}
trsd {
insert ms_v1
insert ks
}
cndt {
insert ks
}
// *************************** assign conductances ****************************
siz {
gbar_nav1p6 = 0.28
gbar_nav1p7 = 0.4
gbar_nav1p8 = 1
gbar_nav1p9 = 0.0004
gbar_kf_a = 0.09
gbar_kf_d = 0.08
gbar_ks = 0.038
}
trsd {
gbar_ms_v1 = 0.00018
m1_ms_v1 = 13.1
m2_ms_v1 = 16900
tau_t_ms_v1 = 1000
slope_m_ms_v1 = 2.07
A_m_ms_v1 = 10
lamda_ms_v1 = 1
dlamda_ms_v1 = 0
tension0_ms_v1 = 4.45
gbar_ks = 0.004
}
mid {
gbar_nav1p6(0:1) = 0:siz.gbar_nav1p6(0.5)
gbar_nav1p7(0:1) = 0:siz.gbar_nav1p7(0.5)
gbar_nav1p8(0:1) = 0:siz.gbar_nav1p8(0.5)
gbar_nav1p9(0:1) = 0:siz.gbar_nav1p9(0.5)
gbar_kf_a(0:1) = 0:siz.gbar_kf_a(0.5)
gbar_kf_d(0:1) = 0:siz.gbar_kf_d(0.5)
gbar_ks(0:1) = trsd.gbar_ks(0.5):siz.gbar_ks(0.5)
}
cndt {
gbar_ks = trsd.gbar_ks(0.5)
}
// *********************************** end assign conductances
}
access mid
celldef()