:Calcium Activated Potassium Channels
NEURON
{
SUFFIX Kca
USEION Ca READ Cai VALENCE 2
USEION Kca WRITE iKca VALENCE 1
RANGE infmKcaV,taumKcaV,eKca,gKcabar,Cahalf
}
UNITS
{
(mA) = (milliamp)
(mV) = (millivolt)
(mS) = (millimho)
(mol)= (1)
(M) = (mol/liter)
(uM) = (micro M)
}
PARAMETER
{
:Ca-dependent K current
eKca=-80 (mV)
gKcabar = 5 (mS/cm2)
Cai
Cahalf=1 (uM)
}
STATE
{
:mKcaV
mKcaCa
}
ASSIGNED
{
iKca (mA/cm^2)
v (mV)
:Ca-dependent potassium channel, Kca
:infmKcaV
:taumKcaV (ms)
gKca (mho/cm2)
}
INITIAL
{ LOCAL Cas
:rate(v)
Cas=Cai*1000 :uM
:mKcaV= infmKcaV
:Cas=Cai
mKcaCa=1/(1+(Cahalf/Cas)^4)
}
BREAKPOINT
{
LOCAL Cas
:SOLVE states METHOD cnexp
Cas=Cai*1000 :uM
mKcaCa=1/(1+(Cahalf/Cas)^4 )
:gKca=(0.001)*gKcabar*(mKcaV^2)*mKcaCa
gKca=(0.001)*gKcabar*mKcaCa^4
iKca=gKca*(v-eKca)
: the current is in the unit of mA/cm2
}