COMMENT
A voltage dependent passive conductance
This passive conductance encompass the experimentally determined voltage dependency of immature hippocampal CA3 neurons
The voltage dependenvy of the resistance was fitted with a Bolzmann function of the expression
g = (gmax/(1+exp(Em-E50)/slope))+gmin) * f
mit gmax = 2300 microsiemens
gmin = 760 microsimens
E50 = -36 mV (=Voltage at Halfmaximal Resistance)
Em = Membrane potential
slope = -6
f = Faktor to normalize rel conductance (siemens/cm2) to total input resistance values
ENDCOMMENT
NEURON {
SUFFIX VDpas
NONSPECIFIC_CURRENT i
RANGE i, e, e50, g, gmin, gmax, s, f
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gmax = 0.002800 (S/cm2)
gmin = 0.000660 (S/cm2)
e50 = -31 (mV)
s = -6
f = 0.051
e = -60 :reversal potential of passive current
}
ASSIGNED {
v (mV) : membrane potential
i (nA) : total current generated by this mechanism
g (uS) : total conductance
}
BREAKPOINT {
g = f*(gmax/(1+exp((v-e50)/s))+gmin)
i = g * (v-e)
}