TITLE Purkinje simplified Cell model
COMMENT
Na channel
Authors: Niceto R. Luque & Richard R. Carrillo
Last revised: 13.9.2018
Paper related:Burst-pause Purkinje dynamics regulate motor adaptation
ENDCOMMENT
NEURON {
SUFFIX Purk_gNa
USEION na READ ena WRITE ina
RANGE gnabar, ina, g
RANGE h_inf, m_inf, tau_h, h
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(molar) = (1/liter)
(mM) = (millimolar)
}
PARAMETER {
v (mV)
gnabar= 0.125 (mho/cm2)
ena = 50 (mV)
}
STATE {
h
}
ASSIGNED {
ina (mA/cm2)
h_inf
m_inf
tau_h (ms)
g (mho/cm2)
}
INITIAL {
rate(v)
h = h_inf
}
BREAKPOINT {
SOLVE states METHOD derivimplicit
m_inf = 1/(1 + exp((-v - 48)/10))
g = gnabar*m_inf*m_inf*m_inf*h
ina = g*(v - ena)
}
DERIVATIVE states {
rate(v)
h' =(h_inf - h)/tau_h
}
PROCEDURE rate(v (mV)) {
tau_h = 0.15 + 1.15/(1 + exp((v + 33.5)/15))
h_inf = 1/(1 + exp((v + 59.4)/10.7))
}