/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__ch_KvAngf
#define _nrn_initial _nrn_initial__ch_KvAngf
#define nrn_cur _nrn_cur__ch_KvAngf
#define _nrn_current _nrn_current__ch_KvAngf
#define nrn_jacob _nrn_jacob__ch_KvAngf
#define nrn_state _nrn_state__ch_KvAngf
#define _net_receive _net_receive__ch_KvAngf
#define rates rates__ch_KvAngf
#define states states__ch_KvAngf
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define gmax _p[0]
#define a0l _p[1]
#define a0n _p[2]
#define zetan _p[3]
#define zetal _p[4]
#define gmn _p[5]
#define gml _p[6]
#define ik _p[7]
#define g _p[8]
#define myi _p[9]
#define n _p[10]
#define l _p[11]
#define ek _p[12]
#define Dn _p[13]
#define Dl _p[14]
#define _g _p[15]
#define _ion_ek *_ppvar[0]._pval
#define _ion_ik *_ppvar[1]._pval
#define _ion_dikdv *_ppvar[2]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_alpl(void);
static void _hoc_alpn(void);
static void _hoc_betl(void);
static void _hoc_betn(void);
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_ch_KvAngf", _hoc_setdata,
"alpl_ch_KvAngf", _hoc_alpl,
"alpn_ch_KvAngf", _hoc_alpn,
"betl_ch_KvAngf", _hoc_betl,
"betn_ch_KvAngf", _hoc_betn,
"rates_ch_KvAngf", _hoc_rates,
0, 0
};
#define alpl alpl_ch_KvAngf
#define alpn alpn_ch_KvAngf
#define betl betl_ch_KvAngf
#define betn betn_ch_KvAngf
extern double alpl( double );
extern double alpn( double );
extern double betl( double );
extern double betn( double );
/* declare global and static user variables */
#define linf linf_ch_KvAngf
double linf = 0;
#define ninf ninf_ch_KvAngf
double ninf = 0;
#define taun taun_ch_KvAngf
double taun = 0;
#define taul taul_ch_KvAngf
double taul = 0;
#define vhalfl vhalfl_ch_KvAngf
double vhalfl = -83;
#define vhalfn vhalfn_ch_KvAngf
double vhalfn = -23.6;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"vhalfn_ch_KvAngf", "mV",
"vhalfl_ch_KvAngf", "mV",
"gmax_ch_KvAngf", "mho/cm2",
"a0l_ch_KvAngf", "/ms",
"a0n_ch_KvAngf", "/ms",
"zetan_ch_KvAngf", "1",
"zetal_ch_KvAngf", "1",
"gmn_ch_KvAngf", "1",
"gml_ch_KvAngf", "1",
"ik_ch_KvAngf", "mA/cm2",
"myi_ch_KvAngf", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double l0 = 0;
static double n0 = 0;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"vhalfn_ch_KvAngf", &vhalfn_ch_KvAngf,
"vhalfl_ch_KvAngf", &vhalfl_ch_KvAngf,
"ninf_ch_KvAngf", &ninf_ch_KvAngf,
"linf_ch_KvAngf", &linf_ch_KvAngf,
"taul_ch_KvAngf", &taul_ch_KvAngf,
"taun_ch_KvAngf", &taun_ch_KvAngf,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"ch_KvAngf",
"gmax_ch_KvAngf",
"a0l_ch_KvAngf",
"a0n_ch_KvAngf",
"zetan_ch_KvAngf",
"zetal_ch_KvAngf",
"gmn_ch_KvAngf",
"gml_ch_KvAngf",
0,
"ik_ch_KvAngf",
"g_ch_KvAngf",
"myi_ch_KvAngf",
0,
"n_ch_KvAngf",
"l_ch_KvAngf",
0,
0};
static Symbol* _k_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 16, _prop);
/*initialize range parameters*/
gmax = 0.01;
a0l = 0.08;
a0n = 0.02;
zetan = -3;
zetal = 4;
gmn = 0.6;
gml = 1;
_prop->param = _p;
_prop->param_size = 16;
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_k_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ek */
_ppvar[1]._pval = &prop_ion->param[3]; /* ik */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dikdv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _ch_KvAngf_reg() {
int _vectorized = 0;
_initlists();
ion_reg("k", -10000.);
_k_sym = hoc_lookup("k_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 16, 4);
hoc_register_dparam_semantics(_mechtype, 0, "k_ion");
hoc_register_dparam_semantics(_mechtype, 1, "k_ion");
hoc_register_dparam_semantics(_mechtype, 2, "k_ion");
hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 ch_KvAngf /Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/ch_KvAngf.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "A-type potassium channel (voltage dependent, for neurogliaform family)";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[2], _dlist1[2];
static int states(_threadargsproto_);
/*VERBATIM*/
#include <stdlib.h> /* Include this library so that the following
(innocuous) warning does not appear:
In function '_thread_cleanup':
warning: incompatible implicit declaration of
built-in function 'free' */
double alpn ( double _lv ) {
double _lalpn;
_lalpn = exp ( 1.e-3 * zetan * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lalpn;
}
static void _hoc_alpn(void) {
double _r;
_r = alpn ( *getarg(1) );
hoc_retpushx(_r);
}
double betn ( double _lv ) {
double _lbetn;
_lbetn = exp ( 1.e-3 * zetan * gmn * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lbetn;
}
static void _hoc_betn(void) {
double _r;
_r = betn ( *getarg(1) );
hoc_retpushx(_r);
}
double alpl ( double _lv ) {
double _lalpl;
_lalpl = exp ( 1.e-3 * zetal * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lalpl;
}
static void _hoc_alpl(void) {
double _r;
_r = alpl ( *getarg(1) );
hoc_retpushx(_r);
}
double betl ( double _lv ) {
double _lbetl;
_lbetl = exp ( 1.e-3 * zetal * gml * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ;
return _lbetl;
}
static void _hoc_betl(void) {
double _r;
_r = betl ( *getarg(1) );
hoc_retpushx(_r);
}
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
rates ( _threadargscomma_ v ) ;
Dn = ( ninf - n ) / taun ;
Dl = ( linf - l ) / taul ;
}
return _reset;
}
static int _ode_matsol1 () {
rates ( _threadargscomma_ v ) ;
Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / taun )) ;
Dl = Dl / (1. - dt*( ( ( ( - 1.0 ) ) ) / taul )) ;
return 0;
}
/*END CVODE*/
static int states () {_reset=0;
{
rates ( _threadargscomma_ v ) ;
n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taun)))*(- ( ( ( ninf ) ) / taun ) / ( ( ( ( - 1.0 ) ) ) / taun ) - n) ;
l = l + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taul)))*(- ( ( ( linf ) ) / taul ) / ( ( ( ( - 1.0 ) ) ) / taul ) - l) ;
}
return 0;
}
static int rates ( double _lv ) {
double _la , _lq10 ;
_lq10 = pow( 3.0 , ( ( celsius - 30.0 ) / 10.0 ) ) ;
_la = alpn ( _threadargscomma_ _lv ) ;
ninf = 1.0 / ( 1.0 + _la ) ;
taun = betn ( _threadargscomma_ _lv ) / ( _lq10 * a0n * ( 1.0 + _la ) ) ;
_la = alpl ( _threadargscomma_ _lv ) ;
linf = 1.0 / ( 1.0 + _la ) ;
taul = betl ( _threadargscomma_ _lv ) / ( _lq10 * a0l * ( 1.0 + _la ) ) ;
return 0; }
static void _hoc_rates(void) {
double _r;
_r = 1.;
rates ( *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ek = _ion_ek;
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ek = _ion_ek;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_k_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_k_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_k_sym, _ppvar, 2, 4);
}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
l = l0;
n = n0;
{
rates ( _threadargscomma_ v ) ;
n = ninf ;
l = linf ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ek = _ion_ek;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
g = gmax * n * l ;
ik = g * ( v - ek ) ;
myi = ik ;
}
_current += ik;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ek = _ion_ek;
_g = _nrn_current(_v + .001);
{ double _dik;
_dik = ik;
_rhs = _nrn_current(_v);
_ion_dikdv += (_dik - ik)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ik += ik ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ek = _ion_ek;
{ error = states();
if(error){fprintf(stderr,"at line 78 in file ch_KvAngf.mod:\n SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
} }}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(n) - _p; _dlist1[0] = &(Dn) - _p;
_slist1[1] = &(l) - _p; _dlist1[1] = &(Dl) - _p;
_first = 0;
}
#if NMODL_TEXT
static const char* nmodl_filename = "/Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/ch_KvAngf.mod";
static const char* nmodl_file_text =
"TITLE A-type potassium channel (voltage dependent, for neurogliaform family)\n"
"\n"
"COMMENT\n"
"A-type potassium channel (voltage dependent, for neurogliaform family)\n"
"\n"
"Ions: k\n"
"\n"
"Style: quasi-ohmic\n"
"\n"
"From: unknown\n"
"\n"
"Updates:\n"
"2014 December (Marianne Bezaire): documented\n"
"ENDCOMMENT\n"
"\n"
"\n"
"VERBATIM\n"
"#include <stdlib.h> /* Include this library so that the following\n"
" (innocuous) warning does not appear:\n"
" In function '_thread_cleanup':\n"
" warning: incompatible implicit declaration of \n"
" built-in function 'free' */\n"
"ENDVERBATIM\n"
"\n"
"UNITS {\n"
" (mA) = (milliamp)\n"
" (mV) = (millivolt)\n"
"}\n"
"\n"
"PARAMETER {\n"
" v (mV)\n"
" ek (mV)\n"
" celsius (degC) : temperature - set in hoc; default is 6.3\n"
" gmax=.01 (mho/cm2)\n"
" vhalfn=-23.6 (mV) : -33.6\n"
" vhalfl=-83 (mV)\n"
" a0l=0.08 (/ms)\n"
" a0n=0.02 (/ms)\n"
" zetan=-3 (1)\n"
" zetal=4 (1)\n"
" gmn=0.6 (1)\n"
" gml=1 (1)\n"
"}\n"
"\n"
"\n"
"NEURON {\n"
" SUFFIX ch_KvAngf\n"
" USEION k READ ek WRITE ik\n"
" RANGE gmax, g, ik\n"
" RANGE myi\n"
" RANGE a0l, a0n, zetan, zetal, gmn, gml\n"
" GLOBAL ninf, linf, taul, taun : note that these four are not thread safe\n"
" THREADSAFE\n"
"}\n"
"\n"
"STATE {\n"
" n\n"
" l\n"
"}\n"
"\n"
"INITIAL {\n"
" rates(v)\n"
" n=ninf\n"
" l=linf\n"
"}\n"
"\n"
"ASSIGNED {\n"
" ik (mA/cm2)\n"
" ninf\n"
" linf \n"
" taul\n"
" taun\n"
" g\n"
" myi (mA/cm2)\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" g = gmax*n*l\n"
" ik = g*(v-ek)\n"
" myi = ik\n"
"\n"
"}\n"
"\n"
"\n"
"FUNCTION alpn(v(mV)) {\n"
" alpn = exp(1.e-3*zetan*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) \n"
"}\n"
"\n"
"FUNCTION betn(v(mV)) {\n"
" betn = exp(1.e-3*zetan*gmn*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))) \n"
"}\n"
"\n"
"FUNCTION alpl(v(mV)) {\n"
" alpl = exp(1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) \n"
"}\n"
"\n"
"FUNCTION betl(v(mV)) {\n"
" betl = exp(1.e-3*zetal*gml*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))) \n"
"}\n"
"\n"
"DERIVATIVE states { \n"
" rates(v)\n"
" n' = (ninf - n)/taun\n"
" l' = (linf - l)/taul\n"
"}\n"
"\n"
"PROCEDURE rates(v (mV)) { :callable from hoc\n"
" LOCAL a,q10\n"
" q10=3^((celsius-30)/10)\n"
" a = alpn(v)\n"
" ninf = 1/(1+a)\n"
" taun = betn(v)/(q10*a0n*(1+a))\n"
" a = alpl(v)\n"
" linf = 1/(1+a)\n"
" taul = betl(v)/(q10*a0l*(1 + a))\n"
"}\n"
"\n"
"\n"
"\n"
"\n"
"\n"
"\n"
"\n"
;
#endif