/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__h15
#define _nrn_initial _nrn_initial__h15
#define nrn_cur _nrn_cur__h15
#define _nrn_current _nrn_current__h15
#define nrn_jacob _nrn_jacob__h15
#define nrn_state _nrn_state__h15
#define _net_receive _net_receive__h15
#define rate rate__h15
#define states states__h15
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define gbar _p[0]
#define i _p[1]
#define minf _p[2]
#define tau _p[3]
#define g _p[4]
#define m _p[5]
#define Dm _p[6]
#define v _p[7]
#define _g _p[8]
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
extern double celsius;
/* declaration of user functions */
static void _hoc_rate(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_h15", _hoc_setdata,
"rate_h15", _hoc_rate,
0, 0
};
/* declare global and static user variables */
#define bD bD_h15
double bD = 1.3;
#define bA bA_h15
double bA = 9.63;
#define erev erev_h15
double erev = -30;
#define k k_h15
double k = 6.4;
#define mD mD_h15
double mD = -0.0447;
#define mA mA_h15
double mA = 0.0458;
#define q10 q10_h15
double q10 = 2.2;
#define taumin taumin_h15
double taumin = 2;
#define vhalf vhalf_h15
double vhalf = -100.6;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"erev_h15", "mV",
"vhalf_h15", "mV",
"taumin_h15", "ms",
"gbar_h15", "mho/cm2",
"i_h15", "mA/cm2",
0,0
};
static double delta_t = 0.01;
static double m0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"erev_h15", &erev_h15,
"vhalf_h15", &vhalf_h15,
"k_h15", &k_h15,
"bA_h15", &bA_h15,
"bD_h15", &bD_h15,
"mA_h15", &mA_h15,
"mD_h15", &mD_h15,
"q10_h15", &q10_h15,
"taumin_h15", &taumin_h15,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[0]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"h15",
"gbar_h15",
0,
"i_h15",
"minf_h15",
"tau_h15",
"g_h15",
0,
"m_h15",
0,
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 9, _prop);
/*initialize range parameters*/
gbar = 0.0001;
_prop->param = _p;
_prop->param_size = 9;
_ppvar = nrn_prop_datum_alloc(_mechtype, 1, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _h_harnett_reg() {
int _vectorized = 1;
_initlists();
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 9, 1);
hoc_register_dparam_semantics(_mechtype, 0, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 h15 /Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/h_harnett.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "I-h channel from Harnett 2015 - J Neurosci";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rate(_threadargsprotocomma_ double);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[1], _dlist1[1];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
rate ( _threadargscomma_ v ) ;
Dm = ( minf - m ) / tau ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
rate ( _threadargscomma_ v ) ;
Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / tau )) ;
return 0;
}
/*END CVODE*/
static int states (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
rate ( _threadargscomma_ v ) ;
m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / tau)))*(- ( ( ( minf ) ) / tau ) / ( ( ( ( - 1.0 ) ) ) / tau ) - m) ;
}
return 0;
}
static int rate ( _threadargsprotocomma_ double _lv ) {
double _lqt ;
_lqt = pow( q10 , ( ( celsius - 26.0 ) / 10.0 ) ) ;
if ( _lv <= - 92.0046199111992 ) {
tau = exp ( bA + mA * _lv ) / _lqt ;
}
else {
tau = exp ( bD + mD * _lv ) / _lqt ;
}
if ( tau < taumin ) {
tau = taumin ;
}
minf = 1.0 / ( 1.0 + exp ( ( _lv - vhalf ) / k ) ) ;
return 0; }
static void _hoc_rate(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = 1.;
rate ( _p, _ppvar, _thread, _nt, *getarg(1) );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 1;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 1; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
m = m0;
{
rate ( _threadargscomma_ v ) ;
m = minf ;
}
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
g = gbar * m ;
i = g * ( v - erev ) ;
}
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ _rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
}
_g = (_g - _rhs)/.001;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ states(_p, _ppvar, _thread, _nt);
}}}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(m) - _p; _dlist1[0] = &(Dm) - _p;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif
#if NMODL_TEXT
static const char* nmodl_filename = "/Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/h_harnett.mod";
static const char* nmodl_file_text =
"TITLE I-h channel from Harnett 2015 - J Neurosci\n"
"\n"
"UNITS {\n"
" (mA) = (milliamp)\n"
" (mV) = (millivolt)\n"
"}\n"
"\n"
"PARAMETER {\n"
" v (mV)\n"
" celsius (degC)\n"
" erev = -30 (mV)\n"
" gbar = 0.0001 (mho/cm2)\n"
" vhalf = -100.6 (mV)\n"
" k = 6.4\n"
" bA = 9.63 : for activation tau - (note - only 1 tau)\n"
" bD = 1.30 : for deactivation tau\n"
" mA = 0.0458 : for activation tau\n"
" mD = -0.0447 : for deactivation tau\n"
" q10 = 2.2\n"
" taumin = 2.0 (ms) : minimal value of time constant\n"
"}\n"
"\n"
"NEURON {\n"
" SUFFIX h15\n"
" NONSPECIFIC_CURRENT i\n"
" RANGE gbar, minf, tau, g, m\n"
" GLOBAL taumin, k, bA, bD, mA, mD, vhalf\n"
"}\n"
"\n"
"STATE {\n"
" m\n"
"}\n"
"\n"
"ASSIGNED {\n"
" i (mA/cm2)\n"
" minf\n"
" tau\n"
" g\n"
"}\n"
"\n"
"INITIAL {\n"
" rate(v)\n"
" m = minf\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" g = gbar*m\n"
" i = g*(v-erev)\n"
"}\n"
"\n"
"DERIVATIVE states { : exact when v held constant; integrates over dt step\n"
" rate(v)\n"
" m' = (minf - m) / tau\n"
"}\n"
"\n"
"PROCEDURE rate(v (mV)) { :callable from hoc - leads to segfault in python\n"
" LOCAL qt\n"
" qt = q10^((celsius-26.0)/10.0)\n"
"\n"
" if(v <= -92.0046199111992) {\n"
" tau = exp(bA + mA * v) / qt \n"
" } else {\n"
" tau = exp(bD + mD * v) / qt\n"
" }\n"
" if(tau < taumin) { tau = taumin }\n"
"\n"
" minf = 1.0/(1.0 + exp((v-vhalf)/k))\n"
"}\n"
;
#endif