/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__MyExp2Syn
#define _nrn_initial _nrn_initial__MyExp2Syn
#define nrn_cur _nrn_cur__MyExp2Syn
#define _nrn_current _nrn_current__MyExp2Syn
#define nrn_jacob _nrn_jacob__MyExp2Syn
#define nrn_state _nrn_state__MyExp2Syn
#define _net_receive _net_receive__MyExp2Syn
#define state state__MyExp2Syn
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
static double *_p; static Datum *_ppvar;
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define tau1 _p[0]
#define tau2 _p[1]
#define e _p[2]
#define i _p[3]
#define g _p[4]
#define A _p[5]
#define B _p[6]
#define factor _p[7]
#define DA _p[8]
#define DB _p[9]
#define _g _p[10]
#define _tsav _p[11]
#define _nd_area *_ppvar[0]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
/* external NEURON variables */
/* declaration of user functions */
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern Prop* nrn_point_prop_;
static int _pointtype;
static void* _hoc_create_pnt(_ho) Object* _ho; { void* create_point_process();
return create_point_process(_pointtype, _ho);
}
static void _hoc_destroy_pnt();
static double _hoc_loc_pnt(_vptr) void* _vptr; {double loc_point_process();
return loc_point_process(_pointtype, _vptr);
}
static double _hoc_has_loc(_vptr) void* _vptr; {double has_loc_point();
return has_loc_point(_vptr);
}
static double _hoc_get_loc_pnt(_vptr)void* _vptr; {
double get_loc_point_process(); return (get_loc_point_process(_vptr));
}
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_p = _prop->param; _ppvar = _prop->dparam;
}
static void _hoc_setdata(void* _vptr) { Prop* _prop;
_prop = ((Point_process*)_vptr)->_prop;
_setdata(_prop);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
0,0
};
static Member_func _member_func[] = {
"loc", _hoc_loc_pnt,
"has_loc", _hoc_has_loc,
"get_loc", _hoc_get_loc_pnt,
0, 0
};
/* declare global and static user variables */
#define total total_MyExp2Syn
double total = 0;
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
"tau2", 1e-09, 1e+09,
"tau1", 1e-09, 1e+09,
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"total_MyExp2Syn", "uS",
"tau1", "ms",
"tau2", "ms",
"e", "mV",
"A", "uS",
"B", "uS",
"i", "nA",
"g", "uS",
0,0
};
static double A0 = 0;
static double B0 = 0;
static double delta_t = 0.01;
static double v = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
"total_MyExp2Syn", &total_MyExp2Syn,
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static void _hoc_destroy_pnt(_vptr) void* _vptr; {
destroy_point_process(_vptr);
}
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[2]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"MyExp2Syn",
"tau1",
"tau2",
"e",
0,
"i",
"g",
0,
"A",
"B",
0,
0};
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
if (nrn_point_prop_) {
_prop->_alloc_seq = nrn_point_prop_->_alloc_seq;
_p = nrn_point_prop_->param;
_ppvar = nrn_point_prop_->dparam;
}else{
_p = nrn_prop_data_alloc(_mechtype, 12, _prop);
/*initialize range parameters*/
tau1 = 0.1;
tau2 = 10;
e = 0;
}
_prop->param = _p;
_prop->param_size = 12;
if (!nrn_point_prop_) {
_ppvar = nrn_prop_datum_alloc(_mechtype, 3, _prop);
}
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _net_receive(Point_process*, double*, double);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _my_exp2syn_reg() {
int _vectorized = 0;
_initlists();
_pointtype = point_register_mech(_mechanism,
nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init,
hoc_nrnpointerindex, 0,
_hoc_create_pnt, _hoc_destroy_pnt, _member_func);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 12, 3);
hoc_register_dparam_semantics(_mechtype, 0, "area");
hoc_register_dparam_semantics(_mechtype, 1, "pntproc");
hoc_register_dparam_semantics(_mechtype, 2, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
pnt_receive[_mechtype] = _net_receive;
pnt_receive_size[_mechtype] = 1;
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 MyExp2Syn /Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/my_exp2syn.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[2], _dlist1[2];
static int state(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 () {_reset=0;
{
DA = - A / tau1 ;
DB = - B / tau2 ;
}
return _reset;
}
static int _ode_matsol1 () {
DA = DA / (1. - dt*( ( - 1.0 ) / tau1 )) ;
DB = DB / (1. - dt*( ( - 1.0 ) / tau2 )) ;
return 0;
}
/*END CVODE*/
static int state () {_reset=0;
{
A = A + (1. - exp(dt*(( - 1.0 ) / tau1)))*(- ( 0.0 ) / ( ( - 1.0 ) / tau1 ) - A) ;
B = B + (1. - exp(dt*(( - 1.0 ) / tau2)))*(- ( 0.0 ) / ( ( - 1.0 ) / tau2 ) - B) ;
}
return 0;
}
static void _net_receive (_pnt, _args, _lflag) Point_process* _pnt; double* _args; double _lflag;
{ _p = _pnt->_prop->param; _ppvar = _pnt->_prop->dparam;
if (_tsav > t){ extern char* hoc_object_name(); hoc_execerror(hoc_object_name(_pnt->ob), ":Event arrived out of order. Must call ParallelContext.set_maxstep AFTER assigning minimum NetCon.delay");}
_tsav = t; {
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = A;
double __primary = (A + _args[0] * factor ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - 1.0 ) / tau1 ) ) )*( - ( 0.0 ) / ( ( - 1.0 ) / tau1 ) - __primary );
A += __primary;
} else {
A = A + _args[0] * factor ;
}
if (nrn_netrec_state_adjust && !cvode_active_){
/* discon state adjustment for cnexp case (rate uses no local variable) */
double __state = B;
double __primary = (B + _args[0] * factor ) - __state;
__primary += ( 1. - exp( 0.5*dt*( ( - 1.0 ) / tau2 ) ) )*( - ( 0.0 ) / ( ( - 1.0 ) / tau2 ) - __primary );
B += __primary;
} else {
B = B + _args[0] * factor ;
}
total = total + _args[0] ;
} }
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_spec1 ();
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 ();
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
_ode_matsol_instance1(_threadargs_);
}}
static void initmodel() {
int _i; double _save;_ninits++;
_save = t;
t = 0.0;
{
A = A0;
B = B0;
{
double _ltp ;
total = 0.0 ;
if ( tau1 / tau2 > .9999 ) {
tau1 = .9999 * tau2 ;
}
A = 0.0 ;
B = 0.0 ;
_ltp = ( tau1 * tau2 ) / ( tau2 - tau1 ) * log ( tau2 / tau1 ) ;
factor = - exp ( - _ltp / tau1 ) + exp ( - _ltp / tau2 ) ;
factor = 1.0 / factor ;
}
_sav_indep = t; t = _save;
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_tsav = -1e20;
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
initmodel();
}}
static double _nrn_current(double _v){double _current=0.;v=_v;{ {
g = B - A ;
i = g * ( v - e ) ;
}
_current += i;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
_g = _nrn_current(_v + .001);
{ _rhs = _nrn_current(_v);
}
_g = (_g - _rhs)/.001;
_g *= 1.e2/(_nd_area);
_rhs *= 1.e2/(_nd_area);
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
{ error = state();
if(error){fprintf(stderr,"at line 72 in file my_exp2syn.mod:\n SOLVE state METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
}}}
}
static void terminal(){}
static void _initlists() {
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(A) - _p; _dlist1[0] = &(DA) - _p;
_slist1[1] = &(B) - _p; _dlist1[1] = &(DB) - _p;
_first = 0;
}
#if NMODL_TEXT
static const char* nmodl_filename = "/Users/salvadord/Documents/ISB/Models/M1_NetPyNE_CellReports_2023/sim/mod/my_exp2syn.mod";
static const char* nmodl_file_text =
"COMMENT\n"
"Two state kinetic scheme synapse described by rise time tau1,\n"
"and decay time constant tau2. The normalized peak condunductance is 1.\n"
"Decay time MUST be greater than rise time.\n"
"\n"
"The solution of A->G->bath with rate constants 1/tau1 and 1/tau2 is\n"
" A = a*exp(-t/tau1) and\n"
" G = a*tau2/(tau2-tau1)*(-exp(-t/tau1) + exp(-t/tau2))\n"
" where tau1 < tau2\n"
"\n"
"If tau2-tau1 -> 0 then we have a alphasynapse.\n"
"and if tau1 -> 0 then we have just single exponential decay.\n"
"\n"
"The factor is evaluated in the\n"
"initial block such that an event of weight 1 generates a\n"
"peak conductance of 1.\n"
"\n"
"Because the solution is a sum of exponentials, the\n"
"coupled equations can be solved as a pair of independent equations\n"
"by the more efficient cnexp method.\n"
"\n"
"ENDCOMMENT\n"
"\n"
"NEURON {\n"
" POINT_PROCESS MyExp2Syn\n"
" RANGE tau1, tau2, e, i\n"
" NONSPECIFIC_CURRENT i\n"
"\n"
" RANGE g\n"
" GLOBAL total\n"
"}\n"
"\n"
"UNITS {\n"
" (nA) = (nanoamp)\n"
" (mV) = (millivolt)\n"
" (uS) = (microsiemens)\n"
"}\n"
"\n"
"PARAMETER {\n"
" tau1 = 0.1 (ms) <1e-9,1e9>\n"
" tau2 = 10 (ms) <1e-9,1e9>\n"
" e = 0 (mV)\n"
"}\n"
"\n"
"ASSIGNED {\n"
" v (mV)\n"
" i (nA)\n"
" g (uS)\n"
" factor\n"
" total (uS)\n"
"}\n"
"\n"
"STATE {\n"
" A (uS)\n"
" B (uS)\n"
"}\n"
"\n"
"INITIAL {\n"
" LOCAL tp\n"
" total = 0\n"
" if (tau1/tau2 > .9999) {\n"
" tau1 = .9999*tau2\n"
" }\n"
" A = 0\n"
" B = 0\n"
" tp = (tau1*tau2)/(tau2 - tau1) * log(tau2/tau1)\n"
" factor = -exp(-tp/tau1) + exp(-tp/tau2)\n"
" factor = 1/factor\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE state METHOD cnexp\n"
" g = B - A\n"
" i = g*(v - e)\n"
"}\n"
"\n"
"DERIVATIVE state {\n"
" A' = -A/tau1\n"
" B' = -B/tau2\n"
"}\n"
"\n"
"NET_RECEIVE(weight (uS)) {\n"
" state_discontinuity(A, A + weight*factor)\n"
" state_discontinuity(B, B + weight*factor)\n"
" total = total+weight\n"
"}\n"
"\n"
"\n"
"\n"
"\n"
"\n"
"\n"
;
#endif