%**************************************************************************
% The following code runs proportional feedback control without noise
%**************************************************************************
function [post_gi, success, gi_traj, M_traj, final_M, n_it] = P_control(N_inputs, N_outputs, rate_Trange, EE_min, rate_t_reg, EE_t_reg,i_signal,i_gsubNa, i_gsubK,i_gL, i_gM, i_gAHP)
graph = 0;
no_EEmax = numel(EE_min)==1; % 1 - only minimum requirement (range); 2 - fixed with tolerance
max_it = 300; % max number of iterations
%% TRIAL PARAMETERS:
time = 1500; % 1.5 sec
pre_stim = 500;
dt = 0.05; % time step for forward euler method
dc = 0; % (uA/cm2) - DC amplitude (NOT USED)
rate_T = mean(rate_Trange);
EE_T = mean(EE_min);
g_lim = [0 4]; % max and min values for conductances
%% Output indices
FR_ind = 1;
EE_ind = 2;
%% Conductance indices
gsubNa_ind = 1;
gsubK_ind = 2;
gL_ind = 3;
gM_ind = 4;
gAHP_ind = 5;
%% Initialize empty arrays
% Conductances (gi)
gsubNa = NaN(max_it,1);
gsubK = NaN(max_it,1);
gleak = NaN(max_it,1);
gM = NaN(max_it,1);
gAHP = NaN(max_it,1);
% Outputs
if N_outputs(EE_ind) ==0 % not regulated
EE = zeros(max_it,1);
EE_error = zeros(max_it,1);
else
EE = NaN(max_it,1);
EE_error = NaN(max_it,1);
end
if N_outputs(FR_ind) ==0 % not regulated
rate = zeros(max_it,1);
rate_error = zeros(max_it,1);
else
rate = NaN(max_it,1);
rate_error = NaN(max_it,1);
end
% Output errors
%% Store initial gi
gsubNa(1) = i_gsubNa;
gsubK(1) = i_gsubK;
gleak(1) = i_gL;
gM(1) = i_gM;
gAHP(1) = i_gAHP;
%% Generate Test Trial
[test] = ML_HH_adapt(time, dt, pre_stim, i_signal, i_gsubNa,i_gsubK,i_gL,i_gM,i_gAHP);
% Calculate rate
curr_rate = sum(test);
% Calculate Energy Efficiency
[min_Na,tot_Na] = calc_EE( i_gsubNa,i_gsubK,i_gL,i_gM,i_gAHP);
curr_EE = min_Na/tot_Na;
rate(1) = curr_rate;
EE(1) = curr_EE;
fprintf(' - Initial values:\n')
fprintf([' gsubNa = ',num2str(i_gsubNa),' ,gsubK = ',num2str(i_gsubK),' ,gleak = ',num2str(i_gL),' ,gM = ',num2str(i_gM),' ,gAHP = ',num2str(i_gAHP),'\n\n'])
fprintf([' Rate = ', num2str(rate(1)), '\n'])
fprintf([' Energy efficiency = ', num2str(EE(1)), '\n\n'])
n_avg = 5; %10; % number of iterations during which outputs need to be on target
on_target = 0; % counts # of it at which output was within target range
prev_on_target = 0;
n_it = 1; % number of iterations b/f reaching target rheobase
while on_target < n_avg && n_it <= max_it-1 % compensation needed
% Terminate if EE is NaN
if isnan(curr_EE) %|| curr_rate == 0
fprintf('Error in calc_EE. Need to adjust Vreset\n')
break;
else
% Compute error (P)
if N_outputs(FR_ind) == 1 % only if rate is being regulated
rate_error(n_it) = curr_rate - rate_T;
end
if N_outputs(EE_ind) == 1 % Energy Efficiency
EE_error(n_it) = curr_EE - EE_T;
end
if no_EEmax == 1 % only minimum requirement (>=)
if EE_error(n_it) >= 0 % if more efficient than minimum
EE_error(n_it) = 0; % no error
end
end
%% Update gi's based on the errors
if N_inputs(gsubNa_ind) == 0 % Subthreshold Na
gsubNa(n_it+1) = i_gsubNa;
else
dgsubNa_it(n_it) = rate_error(n_it)/rate_t_reg(gsubNa_ind)*N_outputs(FR_ind) + EE_error(n_it)/EE_t_reg(gsubNa_ind)*N_outputs(EE_ind);
gsubNa(n_it+1) = gsubNa(n_it) + dgsubNa_it(n_it);
end
if N_inputs(gsubK_ind) == 0 % Subthreshold K
gsubK(n_it+1) = i_gsubK;
else
dgsubK_it(n_it) = rate_error(n_it)/rate_t_reg(gsubK_ind)*N_outputs(FR_ind) + EE_error(n_it)/EE_t_reg(gsubK_ind)*N_outputs(EE_ind);
gsubK(n_it+1) = gsubK(n_it) + dgsubK_it(n_it);
end
if N_inputs(gL_ind) == 0
gleak(n_it+1) = i_gL;
else
dgleak_it(n_it) = rate_error(n_it)/rate_t_reg(gL_ind)*N_outputs(FR_ind) + EE_error(n_it)/EE_t_reg(gL_ind)*N_outputs(EE_ind);
gleak(n_it+1) = gleak(n_it) + dgleak_it(n_it);
end
if N_inputs(gM_ind) == 0
gM(n_it+1) = i_gM;
else
dgM_it(n_it) = rate_error(n_it)/rate_t_reg(gM_ind)*N_outputs(FR_ind) + EE_error(n_it)/EE_t_reg(gM_ind)*N_outputs(EE_ind);
gM(n_it+1) = gM(n_it) + dgM_it(n_it);
end
if N_inputs(gAHP_ind) == 0
gAHP(n_it+1) = i_gAHP;
else
dgAHP_it(n_it) = rate(n_it)/rate_t_reg(gAHP_ind)*N_outputs(FR_ind) + EE_error(n_it)/EE_t_reg(gAHP_ind)*N_outputs(EE_ind);
gAHP(n_it+1) = gAHP(n_it) + dgAHP_it(n_it);
end
%% Conductances capped at 0 (no neg. conductances)
if gsubNa(n_it+1) < 0
gsubNa(n_it+1) = 0;
else if gsubNa(n_it+1) > g_lim(2)
gsubNa(n_it+1) = g_lim(2);
end
end
if gsubK(n_it+1) < 0
gsubK(n_it+1) = 0;
else if gsubK(n_it+1) > g_lim(2)
gsubK(n_it+1) = g_lim(2);
end
end
if gleak(n_it+1) < 1 %**************
gleak(n_it+1) = 1;
else if gleak(n_it+1) > g_lim(2)
gleak(n_it+1) = g_lim(2);
end
end
if gM(n_it+1) < 0 %**************
gM(n_it+1) = 0;
else if gM(n_it+1) > g_lim(2)
gM(n_it+1) = g_lim(2);
end
end
if gAHP(n_it+1) < 0 %**************
gAHP(n_it+1) = 0;
else if gAHP(n_it+1) > g_lim(2)
gAHP(n_it+1) = g_lim(2);
end
end
%% Update output values rate, R, P, and EE
% Generate Test Trial
[test] = ML_HH_adapt(time, dt, pre_stim, i_signal, gsubNa(n_it+1),gsubK(n_it+1),gleak(n_it+1),gM(n_it+1),gAHP(n_it+1));
% Calculate firing rate
curr_rate = sum(test);
rate(n_it+1) = curr_rate;
% Calculate energy efficiency
[min_Na,tot_Na] = calc_EE(gsubNa(n_it+1),gsubK(n_it+1), gleak(n_it+1), gM(n_it+1),gAHP(n_it+1));
curr_EE = min_Na/tot_Na;
EE(n_it+1) = round_JY(curr_EE,4);
%% Check if current output values meet target
M_on_target = zeros(1,numel(N_outputs));
if N_outputs(FR_ind) ~= 0 % rate
M_on_target(FR_ind) = (curr_rate >= rate_Trange(1) && curr_rate <= rate_Trange(2));
end
if N_outputs(EE_ind) ~= 0 % EE
if numel(EE_min) == 1 % When EE > = EEmin
M_on_target(EE_ind) = EE(n_it+1) >= EE_min;
else % EE is fixed (i.e. with tolerance)
M_on_target(EE_ind) = (curr_EE >= EE_min(1) && curr_EE <= EE_min(2) );
end
end
if isequal(N_outputs, M_on_target) % if all outputs are on target
on_target = on_target + 1;
else
on_target = 0;
end
n_it = n_it + 1; % increment number of iterations
end % end of test spontaneous spiking
end % end of while loop
if isnan(curr_EE)
post_gi = [NaN NaN NaN NaN NaN];
final_M = [NaN NaN];
else
% AVERAGED final gi values
avg_gsubNa = mean(gsubNa(n_it-n_avg:n_it));
avg_gsubK = mean(gsubK(n_it-n_avg:n_it));
avg_gleak = mean(gleak(n_it-n_avg:n_it));
avg_gM = mean(gM(n_it-n_avg:n_it));
avg_gAHP = mean(gAHP(n_it-n_avg:n_it));
% NOTE = gsubNa(1) stores initial value. gsubNa(2) stores the value after
% 1st interation
% AVERAGED final output values
avg_rate = mean(rate(n_it-n_avg:n_it));
avg_EE = mean(EE(n_it-n_avg:n_it));
% Store avg values
post_gi = [avg_gsubNa avg_gsubK avg_gleak avg_gM avg_gAHP];
final_M = [avg_rate avg_EE];
end
fprintf(' - Final values: \n')
fprintf([' gsubNa = ',num2str(post_gi(gsubNa_ind)),' ,gsubK = ',num2str(post_gi(gsubK_ind)),' ,gleak = ',num2str(post_gi(gL_ind)),', gM = ',num2str(post_gi(gM_ind)),', gAHP = ',num2str(post_gi(gAHP_ind)),'\n'])
fprintf([' Rate: ' , num2str(curr_rate),'\n'])
fprintf([' EE: ' , num2str(curr_EE),'\n\n'])
if on_target >= n_avg
fprintf(['\n\nSuccess (number of iterations = ',num2str(n_it), ')\n'])
success = 1;
else
fprintf(['\n\nFailure(number of iterations = ',num2str(n_it), ')\n'])
success = 0;
end
on_target
fprintf('\n\n*************************************************\n')
%% Store trajectories of gsubNa, gsubK and gleak
gi_traj = [gsubNa gsubK gleak gM gAHP];
M_traj = [rate EE];
%% Graph
if (graph == 1)
%% settings
grouping = 1; % plot success or failures together
success_only = 2; % 2- plot success & failures together
fontsize = 15;
%% plots
if (success_only == 1 && success==1) || (success_only == 0 && success==0 || (success_only == 2))
if grouping == 1
figure(1)
else
figure %figure(1)
end
hold on
subplot(3,1,1) % conductances
p1_Na = semilogx(1:max_it,gi_traj(:,1),'Color',[0.9290, 0.6940, 0.1250]); % gNa
hold on
p1_K = semilogx(1:max_it,gi_traj(:,2),'Color',[0.4940, 0.1840, 0.5560]); % gK
hold on
p1_M = semilogx(1:max_it,gi_traj(:,4),'b'); % gM
% axis settings
set(gca,'TickDir','out'); box off
ylabel('g_{i}')
xlim([1 max_it])
set(gca,'xscale','log','FontSize',fontsize); % switch to logscale
subplot(3,1,2) % Rate
hold on
p2 = semilogx(1:max_it,M_traj(:,FR_ind),'r'); % firing rate
% xlim([1 n_it])
line([1 n_it],[rate_Trange(1) rate_Trange(1)],'Color','k','LineWidth',1,'LineStyle','--')
line([1 n_it],[rate_Trange(2) rate_Trange(2)],'Color','k','LineWidth',1,'LineStyle','--')
line([1 n_it],[mean(rate_Trange) mean(rate_Trange)],'Color','r','LineWidth',1,'LineStyle','--')
% axis settings
set(gca,'TickDir','out'); box off
ylabel('Rate (spk/s)')
xlim([1 max_it])
set(gca,'xscale','log','FontSize',fontsize); % switch to logscale
subplot(3,1,3) % energy efficiency
hold on
p3 = semilogx(1:max_it,M_traj(:,EE_ind),'g'); % EE
if numel(EE_min)==1
line([1 n_it],[EE_min EE_min],'Color','k','LineWidth',1,'LineStyle','--')
else
line([1 n_it],[EE_min(1) EE_min(1)],'Color','k','LineWidth',1,'LineStyle','--')
line([1 n_it],[EE_min(2) EE_min(2)],'Color','k','LineWidth',1,'LineStyle','--')
end
line([1 n_it],[mean(EE_min) mean(EE_min)],'Color','g','LineWidth',1,'LineStyle','--')
hold off
% axis settings
xlabel('# of iterations');ylabel('EE (%)');
set(gca,'TickDir','out'); box off
xlim([1 200])
set(gca,'xscale','log','FontSize',fontsize); % switch to logscale
set(gcf,'position',[10 86 560 892])
end
end % end of if graph==1
end % end of function