proc celldef() {
topol()
subsets()
geom()
biophys()
// geom_nseg()
}
create soma, ABD[2], interD, axoD, axonstart, AIS, axon
create nABD[3], nABD_sec[12]
proc topol() { local i
connect ABD(0), soma(1)
connect ABD[1](0), ABD(1)
connect interD(0), ABD(1)
connect axoD(0), ABD[1](1)
connect axonstart(0), ABD[1](1)
connect AIS(0), axonstart(1)
connect axon(0), AIS(1)
for i = 0, 2 connect nABD[i](0), soma(0)
for i = 0, 1 connect nABD_sec[i](0), nABD(1)
for i = 2, 3 connect nABD_sec[i](0), nABD_sec(1)
for i = 4, 5 connect nABD_sec[i](0), nABD_sec[1](1)
for i = 6, 7 connect nABD_sec[i](0), nABD[1](1)
for i = 8, 9 connect nABD_sec[i](0), nABD_sec[7](1)
for i = 10, 11 connect nABD_sec[i](0), nABD_sec[9](1)
basic_shape()
}
proc basic_shape() {
soma {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(15, 0, 0, 1)}
ABD {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(45, 0, 0, 1)}
ABD[1] {pt3dclear() pt3dadd(45, 0, 0, 1) pt3dadd(60, -14, 0, 1)}
interD {pt3dclear() pt3dadd(45, 0, 0, 1) pt3dadd(60, 30, 0, 1)}
axoD {pt3dclear() pt3dadd(60, -14, 0, 1) pt3dadd(105, -14, 0, 1)}
axonstart {pt3dclear() pt3dadd(60, -14, 0, 1) pt3dadd(60, -44, 0, 1)}
AIS {pt3dclear() pt3dadd(60, -44, 0, 1) pt3dadd(60, -74, 0, 1)}
axon {pt3dclear() pt3dadd(60, -74, 0, 1) pt3dadd(60, -134, 0, 1)}
nABD {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-14, 75, 0, 1)}
nABD[1] {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-59, 0, 0, 1)}
nABD[2] {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-29, -59, 0, 1)}
nABD_sec {pt3dclear() pt3dadd(-14, 75, 0, 1) pt3dadd(0, 90, 0, 1)}
nABD_sec[1] {pt3dclear() pt3dadd(-14, 75, 0, 1) pt3dadd(-44, 90, 0, 1)}
nABD_sec[2] {pt3dclear() pt3dadd(0, 90, 0, 1) pt3dadd(0, 120, 0, 1)}
nABD_sec[3] {pt3dclear() pt3dadd(0, 90, 0, 1) pt3dadd(30, 90, 0, 1)}
nABD_sec[4] {pt3dclear() pt3dadd(-44, 90, 0, 1) pt3dadd(-44, 120, 0, 1)}
nABD_sec[5] {pt3dclear() pt3dadd(-44, 90, 0, 1) pt3dadd(-74, 90, 0, 1)}
nABD_sec[6] {pt3dclear() pt3dadd(-59, 0, 0, 1) pt3dadd(-89, -29, 0, 1)}
nABD_sec[7] {pt3dclear() pt3dadd(-59, 0, 0, 1) pt3dadd(-89, 15, 0, 1)}
nABD_sec[8] {pt3dclear() pt3dadd(-89, 15, 0, 1) pt3dadd(-134, 15, 0, 1)}
nABD_sec[9] {pt3dclear() pt3dadd(-89, 15, 0, 1) pt3dadd(-104, 45, 0, 1)}
nABD_sec[10] {pt3dclear() pt3dadd(-104, 45, 0, 1) pt3dadd(-134, 45, 0, 1)}
nABD_sec[11] {pt3dclear() pt3dadd(-104, 45, 0, 1) pt3dadd(-104, 75, 0, 1)}
}
objref all, all_biophys, all_ABD
proc subsets() { local i
objref all, all_biophys, all_ABD
all = new SectionList()
soma all.append()
for i=0, 1 ABD[i] all.append()
interD all.append()
axoD all.append()
axonstart all.append()
AIS all.append()
axon all.append()
for i=0, 2 nABD[i] all.append()
for i=0, 11 nABD_sec[i] all.append()
all_biophys = new SectionList()
for i=0, 1 ABD[i] all_biophys.append()
interD all_biophys.append()
axoD all_biophys.append()
axonstart all_biophys.append()
for i=0, 2 nABD[i] all_biophys.append()
for i=0, 11 nABD_sec[i] all_biophys.append()
all_ABD= new SectionList()
for i=0, 1 ABD[i] all_ABD.append()
interD all_ABD.append()
axoD all_ABD.append()
axonstart all_ABD.append()
}
proc geom() {
soma { L = 19 }
ABD { L = 24 }
ABD[1] { L = 12 }
interD { L = 297 }
axoD { L = 6 }
axonstart { L = 23.4 }
AIS { L = 28.4 }
axon { L = 800 }
nABD { L = 88 }
nABD[1] { L = 67 }
nABD[2] { L = 381 }
nABD_sec { L = 20 }
nABD_sec[1] { L = 136 }
nABD_sec[2] { L = 353 }
nABD_sec[3] { L = 184 }
nABD_sec[4] { L = 5 }
nABD_sec[5] { L = 115 }
nABD_sec[6] { L = 117 }
nABD_sec[7] { L = 33 }
nABD_sec[8] { L = 8 }
nABD_sec[9] { L = 3 }
nABD_sec[10] { L = 72 }
nABD_sec[11] { L = 376 }
// nseg definition has to be launched before diam definition for tapering to be taken into account
forsec all { nseg = int((L/(0.1*lambda_f(1000))+.999)/2)*2 + 1 }
soma { diam = 10 }
ABD { diam(0:1) = 3.2: 3 }
ABD[1] { diam(0:1) = 3:2.8 }
interD { diam(0:1) = 2.1:0.8 }
axoD { diam(0:1) = 1.45:1.4 }
axonstart { diam(0:1) = 1.89: 1.35 }
AIS { diam(0:1) = 1.35:0.83 }
axon { diam = 0.83 }
nABD { diam(0:1) = 1.6:1.4 }
nABD[1] { diam(0:1) = 2:1.8 }
nABD[2] { diam(0:1) = 2.5:0.8 }
nABD_sec { diam = 1 }
nABD_sec[1] { diam = 1 }
nABD_sec[2] { diam = 0.8 }
nABD_sec[3] { diam = 0.8 }
nABD_sec[4] { diam = 0.8 }
nABD_sec[5] { diam = 0.8 }
nABD_sec[6] { diam(0:1) = 1:0.8 }
nABD_sec[7] { diam = 1 }
nABD_sec[8] { diam = 1 }
nABD_sec[9] { diam = 1 }
nABD_sec[10] { diam = 0.8 }
nABD_sec[11] { diam = 0.8 }
}
proc biophys() {
forsec all {
Ra = 150
cm = 0.75
}
forsec all_biophys {
insert pasnts
g_pasnts = 1e-05
e_pasnts = -50
insert kca
gbar_kca = 0.1
insert cad
insert Na12
gbar_Na12 = 75
insert kdrDA
gbar_kdrDA = 150
insert kaDa
gbar_kaDa = 50
taurecov_kaDa = 25
insert Ih
gbar_Ih = 3
insert CAV13
gbar_CAV13 = 1.25
iLCa_CAV13 = 0
}
soma {
insert pasnts
g_pasnts = 1e-05
e_pasnts = -50
insert kca
gbar_kca = 0.1
insert cad
insert Na12
gbar_Na12 = 75
insert kdrDA
gbar_kdrDA = 150
insert kaDasoma
gbar_kaDasoma = 150
taurecov_kaDasoma = 25
insert Ih
gbar_Ih = 3
insert CAV13
gbar_CAV13 = 1.25
iLCa_CAV13 = 0
}
AIS {
insert pasnts
g_pasnts = 1e-05
e_pasnts = -50
insert Na12
gbar_Na12 = 4000
insert kdrDA
gbar_kdrDA = 4000
}
axon {
insert pasnts
g_pasnts = 1e-05
e_pasnts = -50
insert Na12
gbar_Na12 = 400
insert kdrDA
gbar_kdrDA = 400
}
forsec all { ek=-90
ena=60 }
}
access soma
celldef()