TITLE Fast Sodium current
: Unit check passed
INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
NEURON {
SUFFIX NaF
USEION na READ ena WRITE ina
RANGE g, gmax, ina
GLOBAL minf, mtau, hinf, htau
}
PARAMETER { : PARAMETERS ARE BY DEFAULT GLOBAL VARIABLES
gmax = 0.0195 (mho/cm2)
ena (mV)
m_vh = -23.9 (mV) : half activation
m_ve = -11.8 (mV) : slope
h_vh = -62.9 (mV) : half activation
h_ve = 10.7 (mV) : slope
}
ASSIGNED {
v (mV)
g (mho/cm2)
ina (mA/cm2)
minf (1)
mtau (ms)
hinf (1)
htau (ms)
}
STATE {
m h
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax * m*m*m * h
ina = g * (v - ena )
}
INITIAL {
rates(v)
m = minf
h = hinf
}
DERIVATIVE states {
rates(v)
m' = ( minf - m ) / mtau
h' = ( hinf - h ) / htau
}
FUNCTION_TABLE tabmtau(v(mV)) (ms)
FUNCTION_TABLE tabhtau(v(mV)) (ms)
PROCEDURE rates(v(mV)) {
TABLE mtau, htau, minf, hinf DEPEND h_vh FROM -120 TO 40 WITH 160
: TABLE mtau, htau, minf, hinf DEPEND h_vh FROM -120 TO 40 WITH 320
mtau = tabmtau(v)
htau = tabhtau(v)
minf = 1/(1 + exp((v - m_vh)/m_ve))
hinf = 1/(1 + exp((v - h_vh)/h_ve))
}