TITLE Ih channels in VCN auditory neurons
: ih=ghmax*r*(v-eh)
: based on Rothman and Manis (2003c)
: Modifications by Yi Zhou for an MSO model
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX ih_VCN2003
USEION h READ eh WRITE ih VALENCE 1
RANGE ghbar
RANGE r_inf,tau_r,r_exp
RANGE ih,gh
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
ghbar = 0.002 (mho/cm2)
eh=-43 (mV)
celsius =22 (degC)
dt (ms)
v (mV)
}
STATE {
r
}
ASSIGNED {
gh (mho/cm2)
ih (mA/cm2)
r_inf
tau_r
r_exp
tadj
}
BREAKPOINT {
SOLVE states
gh=ghbar *r
ih = gh*(v-eh)
}
PROCEDURE states() { : this discretized form is more stable
evaluate_fct(v)
r = r + r_exp * (r_inf - r)
VERBATIM
return 0;
ENDVERBATIM
}
UNITSOFF
INITIAL {
:
: Q10 was assumed to be 3 for both currents
:
tadj = 3.0 ^ ((celsius-22)/ 10 )
evaluate_fct(v)
r= r_inf
}
PROCEDURE evaluate_fct(v(mV)) {
tau_r = (100000/(237*exp((v+60)/12)+17*exp(-(v+60)/14))+25)/ tadj
r_inf = 1/(1+exp((v+76)/7))
r_exp = 1 - exp(-dt/tau_r)
}
UNITSON