//genesis // SynParamsCtx.g /*************************** MS Model, Version 7.6 ********************* **************************** SynParamsCtx.g ********************* Avrama Blackwell kblackw1@gmu.edu Rebekah Evans rcolema2@gmu.edu Tom Sheehan tsheeha2@gmu.edu ****************************************************************************** To change synaptic parameters, change the include in MScellSpine.g Synaptic Parameters for cortical inputs according to Ding ... Surmeier *****************************************************************************/ str AMPAname = "AMPA" float EkAMPA = 0.0 float AMPAtau1 = 1.1e-3 float AMPAtau2 = 5.75e-3 float AMPAgmax = 0.342e-9 //593e-12 I changed this to make the NMDA/AMPA ratio more like 2.75/1 which is what Ding 2008 finds int corticalstriatal synapses //more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10 str GABAname = "GABA" float GABAtau1 = 0.25e-3 // From Galarreta and Hestrin 1997 float GABAtau2 = 3.75e-3 float EkGABA = -0.060 float GABAgmax = 750e-12 //Modified Koos 2004 int GABA2Spine = 0 // = 0, No GABA; int addCa2Spine = 1 // 0, no ca channels in spine, //1, yes ca channels in spine (non-synaptic) int NMDABufferMode = 0 // 1, connect both NMDA and AMPA calcium to NMDA_buffer // 0, connect only NMDA currents to NMDA_buffer float useAMPANMDAGHKchannels= 0 // we are not using GHK for NMDA/AMPA // parameters for NMDA subunits // cortex str subunit = "Cortex" float EkNMDA = 0 float Kmg = 3.57 float NMDAtau2 = (112.5e-3)/2 //ctx avg for .25 NR2B and .75 NR2A. (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 75+37.5 = 112.5 float NMDAgmax = 0.94e-9 //NR2A and B from (Moyner et al., 1994 figure 7) int ghk_yesno=0 str NMDAname = {subunit}