//genesis // CaL12inact_channel.g /*************************** MS Model, Version 7.6 ********************* **************************** CaL12inact_channel.g ********************* Avrama Blackwell kblackw1@gmu.edu Rebekah Evans rcolema2@gmu.edu Tom Sheehan tsheeha2@gmu.edu ****************************************************************************** *****************************************************************************/ function create_CaL12 str chanName = "CaL12_channel" str compPath = "/library" int c float xmin = -0.1 float xmax = 0.05 int xdivs = 3000 float mPower = 1.0 float hPower = 1.0 float increment ={{xmax}-{xmin}}/{xdivs} echo "CaL12 increment:" {increment} "V" float x = -0.1 float surf = 0 float gMax = 0 float hTauCaL12 = 1.477e-002 float mTauCaL12 = 0.0 float mvHalfCaL12 = -8.9e-3 float mkCaL12 = -6.7e-3 float hvHalfCaL12 = -13.4e-3 float hkCaL12 = 11.9e-3 float hInfCaL12 = 0.0 float mInfCaL12 = 0.0 float theta = 0.0 float beta = 0.0 float beta_exp = 0.0 float mA = 0.0 float mB = 0.0 float qFactCaL12 =2 pushe {compPath} create tabchannel {chanName} setfield {chanName} Xpower {mPower} Ypower {hPower} call {chanName} TABCREATE X {xdivs} {xmin} {xmax} call {chanName} TABCREATE Y {xdivs} {xmin} {xmax} for(c = 0; c < {xdivs} + 1; c = c + 1) /************************ Begin CaL12_mTau *********************/ //mA = 0.0398e6*(vMemb + 8.124e-3)./(exp((vMemb + 8.124e-3)/9.005e-3) - 1); //mB = 0.99e3*exp(vMemb/31.4e-3); //mTauCaL12 = 1./(mA + mB) / qFactCaL12; theta = 0.0398e6*{ {x} + 8.124e-3} beta = {{x} + 8.124e-3}/9.005e-3 beta_exp = {{exp {beta}} - 1.0} mA = {{theta}/{beta_exp}} beta = {{x}/31.4e-3} beta_exp = {exp {beta}} mB = 0.99e3*{beta_exp} mTauCaL12 = {1/{mA + mB}}/{qFactCaL12} setfield {chanName} X_A->table[{c}] {mTauCaL12} /************************ End CaL12_mTau ***********************/ /************************ Begin CaL12_mInf *********************/ // mInfCaL12 = 1./(1 + exp((vMemb - mvHalfCaL12)/mkCaL12)); beta = {{x} - {mvHalfCaL12}}/{mkCaL12} beta_exp = {exp {beta}} + 1.0 mInfCaL12 = 1.0/{beta_exp} setfield {chanName} X_B->table[{c}] {mInfCaL12} /************************ End CaL12_mInf ***********************/ /************************ Begin CaL12_hTau *********************/ // hTauCaL12 = 14.77e-3*ones(vDiv+1,1); % Already q-corrected setfield {chanName} Y_A->table[{c}] {hTauCaL12} /************************ End CaL12_hTau ***********************/ /************************ Begin CaL12_hInf *********************/ // hInfCaL12 = 1./(1 + exp((vMemb - hvHalfCaL12)/hkCaL12)); beta = {{x} - {hvHalfCaL12}}/{hkCaL12} beta_exp = {exp {beta}} + 1.0 //0.17 has vdep inactivation, 0.83 does not inactivate hInfCaL12 = {0.17*{1.0/{beta_exp}} + 0.83} setfield {chanName} Y_B->table[{c}] {hInfCaL12} /************************ End CaL12_hInf ***********************/ x = x + increment end tweaktau {chanName} X tweaktau {chanName} Y create ghk {chanName}GHK setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, setfield {chanName}GHK valency 2.0 setfield {chanName}GHK T {TEMPERATURE} setfield {chanName} Gbar {gMax*surf} addmsg {chanName} {chanName}GHK PERMEABILITY Gk pope end