//genesis // CaL13_channel.g /*************************** MS Model, Version 7.6 ********************* **************************** CaL13_channel.g ********************* Avrama Blackwell kblackw1@gmu.edu Rebekah Evans rcolema2@gmu.edu Tom Sheehan tsheeha2@gmu.edu ****************************************************************************** *****************************************************************************/ function create_CaL13 str chanName = "CaL13_channel" str compPath = "/library" int c float x = -0.1 int xdivs = 3000 float xmin = -0.1 float xmax = 0.05 float increment ={{xmax}-{xmin}}/{xdivs} echo "CaL13 increment:" {increment} "V" float mPower = 2.0 float hPower = 1.0 float hTauCaL13 = 1.477e-002 float mTauCaL13 = 0.0 float mvHalfCaL13 = -33.0e-3 float mkCaL13 = -6.7e-3 float hvHalfCaL13 = -13.4e-3 float hkCaL13 = 11.9e-3 float hInfCaL13 = 0.0 float mInfCaL13 = 0.0 float theta = 0.0 float beta = 0.0 float beta_exp = 0.0 float mA = 0.0 float mB = 0.0 float surf = 0 float qFactCaL13 = 2 float gMax = 4.25e-009 pushe {compPath} create tabchannel {chanName} setfield {chanName} Xpower {mPower} Ypower {hPower} call {chanName} TABCREATE X {xdivs} {xmin} {xmax} call {chanName} TABCREATE Y {xdivs} {xmin} {xmax} for(c = 0; c < {xdivs} + 1; c = c + 1) /************************ Begin CaL13_mTau *********************/ //mA = 0.0398e6*(vMemb + 8.124e-3)./ // (exp((vMemb + 8.124e-3)/9.005e-3) - 1); //mB = 0.99e3*exp(vMemb/31.4e-3); //mTauCaL12 = 1./(mA + mB) / qFactCaL12; theta = 0.0398e6*{ {x} + 8.124e-3} beta = {{x} + 8.124e-3}/9.005e-3 beta_exp = {exp {beta}} beta_exp = beta_exp - 1.0 mA = {{theta}/{beta_exp}} beta = {{x}/31.4e-3} beta_exp = {exp {beta}} mB = 0.99e3*{beta_exp} mTauCaL13 = {1.0/{mA + mB}}/{qFactCaL13} setfield {chanName} X_A->table[{c}] {mTauCaL13} /************************ End CaL13_mTau ***********************/ /************************ Begin CaL13_mInf *********************/ // mInfCaL13 = 1./(1 + exp((vMemb - mvHalfCaL13)/mkCaL13)); beta = {{x} - {mvHalfCaL13}}/{mkCaL13} beta_exp = {exp {beta}} + 1.0 mInfCaL13 = 1.0/{beta_exp} setfield {chanName} X_B->table[{c}] {mInfCaL13} /************************ End CaL13_mInf ***********************/ /************************ Begin CaL13_hTau *********************/ // hTauCaL13 = 14.77e-3*ones(vDiv+1,1); % Already q-corrected setfield {chanName} Y_A->table[{c}] {hTauCaL13} /************************ End CaL13_hTau ***********************/ /************************ Begin CaL13_hInf *********************/ // hInfCaL13 = 1./(1 + exp((vMemb - hvHalfCaL13)/hkCaL13)); beta = {{x} - {hvHalfCaL13}}/{hkCaL13} beta_exp = {exp {beta}} + 1.0 hInfCaL13 = 1.0/{beta_exp} setfield {chanName} Y_B->table[{c}] {hInfCaL13} /************************ End CaL13_hInf ***********************/ x = x + increment end tweaktau {chanName} X tweaktau {chanName} Y create ghk {chanName}GHK setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, setfield {chanName}GHK valency 2.0 setfield {chanName}GHK T {TEMPERATURE} setfield {chanName} Gbar {gMax*surf} addmsg {chanName} {chanName}GHK PERMEABILITY Gk pope end