load_file("nrngui.hoc")
load_file("mitral.hoc")
load_file("gc.hoc")
cvode.active(1)
Vrest = -65
dt = 1
celsius=35
tstop=500
objref nconp[3], net, netp[3], g, b, synp, nil, stim, apc
objref mt[3], gc[3], train, outfile, coeff[3], table
objref nc[27]
strdef filename
outfile = new File()
table = new Vector()
for i=0, 2 {
mt[i] = new Mitral()
gc[i] = new GC()
coeff[i] = new Vector()
}
outfile.ropen("coeff-table.txt")
for i=0, 2 {
for j=0,8 {
coeff[i].append(outfile.scanvar())
}
coeff[i].printf()
}
outfile.close()
cx=3
weight=.1
amp=.03
rel=0.2
inh=13
synstr=2.3
nmdafactor=0.0035
frac=1
b = new VBox()
b.intercept(1)
g = new Graph()
g.size(0,tstop,-70,0)
g.xaxis(1)
g.addvar("mt[0].soma.v(0.5)",1,1,0.7,1,2)
g.addvar("mt[1].soma.v(0.5)",2,1,0.7,0.99,2)
g.addvar("mt[2].soma.v(0.5)",3,1,0.7,0.98,2)
g.exec_menu("10% Zoom out")
xpanel("",1)
xbutton("run", "run()")
xvalue("odor","cx")
xpanel()
b.intercept(0)
b.map()
for i=0, 2 {
access mt[i].soma
distance()
netp[i] = new NetStim(0)
netp[i].number=1
netp[i].interval=500
netp[i].noise=0
netp[i].start=2
nconp[i]= new NetCon(netp[i],mt[i].synodor,0.5,0,weight*1.e-3)
}
////////////////// circuit definition
///// gc <-> mt
gc[0].dend[0] nc[0]= new NetCon(&v(1),mt[0].igp[1][0],-40,1,inh*1e-3)
mt[0].secden[1] nc[1]= new NetCon(&v(0),gc[0].synmt[0],-40,1,synstr*nmdafactor)
mt[0].secden[1] nc[2]= new NetCon(&v(0),gc[0].sampa[0],-40,1,synstr*1e-3)
gc[0].dend[2] nc[3]= new NetCon(&v(1),mt[1].igp[0][1],-40,1,inh*1e-3)
mt[1].secden[0] nc[4]= new NetCon(&v(0.4),gc[0].synmt[1],-40,1,synstr*nmdafactor)
mt[1].secden[0] nc[5]= new NetCon(&v(0.4),gc[0].sampa[1],-40,1,synstr*1e-3)
gc[0].dend[4] nc[6]= new NetCon(&v(1),mt[2].igp[0][2],-40,1,inh*1e-3)
mt[2].secden[0] nc[7]= new NetCon(&v(0.8),gc[0].synmt[2],-40,1,synstr*nmdafactor)
mt[2].secden[0] nc[8]= new NetCon(&v(0.8),gc[0].sampa[2],-40,1,synstr*1e-3)
gc[1].dend[0] nc[9]= new NetCon(&v(1),mt[1].igp[1][0],-40,1,inh*1e-3)
mt[1].secden[1] nc[10]= new NetCon(&v(0),gc[1].synmt[0],-40,1,synstr*nmdafactor)
mt[1].secden[1] nc[11]= new NetCon(&v(0),gc[1].sampa[0],-40,1,synstr*1e-3)
gc[1].dend[2] nc[12]= new NetCon(&v(1),mt[2].igp[0][1],-40,1,inh*1e-3)
mt[2].secden[0] nc[13]= new NetCon(&v(0.4),gc[1].synmt[1],-40,1,synstr*nmdafactor)
mt[2].secden[0] nc[14]= new NetCon(&v(0.4),gc[1].sampa[1],-40,1,synstr*1e-3)
gc[1].dend[4] nc[15]= new NetCon(&v(1),mt[0].igp[1][1],-40,1,inh*1e-3)
mt[0].secden[1] nc[16]= new NetCon(&v(0.4),gc[1].synmt[2],-40,1,synstr*nmdafactor)
mt[0].secden[1] nc[17]= new NetCon(&v(0.4),gc[1].sampa[2],-40,1,synstr*1e-3)
gc[2].dend[0] nc[18]= new NetCon(&v(1),mt[2].igp[1][0],-40,1,inh*1e-3)
mt[2].secden[1] nc[19]= new NetCon(&v(0),gc[2].synmt[0],-40,1,synstr*nmdafactor)
mt[2].secden[1] nc[20]= new NetCon(&v(0),gc[2].sampa[0],-40,1,synstr*1e-3)
gc[2].dend[2] nc[21]= new NetCon(&v(1),mt[1].igp[1][1],-40,1,inh*1e-3)
mt[1].secden[1] nc[22]= new NetCon(&v(0.4),gc[2].synmt[1],-40,1,synstr*nmdafactor)
mt[1].secden[1] nc[23]= new NetCon(&v(0.4),gc[2].sampa[1],-40,1,synstr*1e-3)
gc[2].dend[4] nc[24]= new NetCon(&v(1),mt[0].igp[1][2],-40,1,inh*1e-3)
mt[0].secden[1] nc[25]= new NetCon(&v(0.8),gc[2].synmt[2],-40,1,synstr*nmdafactor)
mt[0].secden[1] nc[26]= new NetCon(&v(0.8),gc[2].sampa[2],-40,1,synstr*1e-3)
////////////////// end circuit definition
proc init() {
t=0
finitialize(Vrest)
fcurrent()
forall {
v=Vrest
if (ismembrane("nax")) {e_pas=v+(ina+ik)/g_pas
} else {
e_pas=v+ik/g_pas
}
}
cvode.re_init()
g.begin()
g.plot(t)
}
proc advance() {
fadvance()
g.plot(t)
g.flush()
doNotify()
}
proc run() {
for i=0, 2 {
nconp[i].weight=coeff[i].x[cx-3]*1.e-3
print i, nconp[i].weight
}
stdinit()
continuerun(tstop)
}