TITLE PUMP
: FORREST MD (2014) Two Compartment Model of the Cerebellar Purkinje Neuron
UNITS {
(molar) = (1/liter)
(pA) = (picoamp)
(mV) = (millivolt)
(uS) = (micromho)
(mA) = (milliamp)
(mM) = (millimolar)
}
INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}
NEURON {
SUFFIX mypump
: USEION Na WRITE iNa VALENCE 1
: USEION na READ nai
USEION na WRITE ina
USEION k WRITE ik
RANGE inapump,ipumpmax,n,km,kk,k,ina,ik,decline,initialdensity,lex,red,lux,green
}
PARAMETER {
dt (ms)
nai (mM)
ipumpmax = 0.01 (mA/cm2)
km = 10.0 (mM)
n=1.5
kk = 10.0 (mM)
k = 1.5
nainit = 4 (mM)
celsius = 35 (degC)
T = 1
decline = 0
initialdensity = 0.00208768267 (mA/cm2)
lex = 100000 (ms) : if 100 then we get fast declining pump. if like 100,000. then we dont really get decline
lux = 100000 (ms)
red = 3000 (ms)
green = 8500 (ms)
: corrD = 4.79
}
ASSIGNED {
ina (mA/cm2)
iNa (mA/cm2)
ik (mA/cm2)
inapump (mA/cm2)
: ipumpmax (mA/cm2)
inapumping (mA/cm2)
xm
t_wait (ms)
t_date (ms)
ipumplux (mA/cm2)
}
INITIAL{
ipumpmax = initialdensity
t_wait = 0
}
BREAKPOINT {
if (decline == 1) {
if ( t > red) {
if (t_wait < lex)
{t_wait = t_wait + dt }
else {
ipumpmax = ipumpmax - 0.001
t_wait = 0 : this resets the counter.
}
}
if (ipumpmax < 0) {ipumpmax = 0}
}
ina = 3.0*ipumpmax
ik = -2.0*ipumpmax
}