TITLE transient potassium current (A-current)
COMMENT
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reference: Huguenard & McCormick (1992)
J.Neurophysiology 68(4), 1373-1383
found in: thalamic relay neurons
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Original by Alain Destexhe
Rewritten for MyFirstNEURON by Arthur Houweling
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX iA
USEION k READ ek WRITE ik
RANGE gkbar, m_inf1, tau_m, h_inf, tau_h1, ik
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
celsius (degC)
dt (ms)
ek (mV)
gkbar= 0.009 (mho/cm2)
: gkbar= 0.00345 (mho/cm2)
}
STATE {
m1 h1
}
ASSIGNED {
ik (mA/cm2)
m_inf1
tau_m (ms)
h_inf
tau_h1 (ms)
tadj
}
BREAKPOINT {
SOLVE states :METHOD euler
ik = gkbar * m1^4*h1 * (v-ek)
}
:DERIVATIVE states {
: evaluate_fct(v)
:
: m1'= (m_inf1-m1) / tau_m
: h1'= (h_inf-h1) / tau_h1
:}
PROCEDURE states() {
evaluate_fct(v)
m1= m1 + (1-exp(-dt/tau_m))*(m_inf1-m1)
h1= h1 + (1-exp(-dt/tau_h1))*(h_inf-h1)
}
UNITSOFF
INITIAL {
: tadj = 2.3^((celsius-23)/10)
tadj = 3^((celsius-23.5)/10)
evaluate_fct(v)
m1 = m_inf1
h1 = h_inf
}
PROCEDURE evaluate_fct(v(mV)) { LOCAL a,b
tau_m = 1.0/((exp((v+35.82)/19.69)+exp(-(v+79.69)/12.7))+0.37) / tadj
m_inf1 = 1.0 / (1+exp(-(v+60)/8.5))
a = 1.0/((exp((v+46.05)/5)+exp(-(v+238.4)/37.45))) / tadj
if (v<-63) {
tau_h1 = a
}
else {
tau_h1 = 19.0/tadj
}
h_inf = 1.0/(1+exp((v+78)/6))
}
UNITSON