COMMENT
synaptic current with exponential rise and decay conductance defined by
i = g * (v - e) i(nanoamps), g(micromhos);
where
g = 0 for t < onset and
g=amp*((1-exp(-(t-onset)/tau0))-(1-exp(-(t-onset)/tau1)))
for t > onset
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
POINT_PROCESS synnm
RANGE g, onset, tau0, tau1, gmax, e, i, mg
NONSPECIFIC_CURRENT i
}
UNITS {
(nA) = (nanoamp)
(mV) = (millivolt)
(umho) = (micromho)
}
PARAMETER {
onset=0 (ms)
:tau1=86 (ms) :Parameters from Destexhe et al (1994), through Abbott and Dayan
:tau2=1.585 (ms) :Parameters from Destexhe et al (1994), through Abbott and Dayan
tau1=78 (ms)
tau2=2 (ms)
gmax=0 (umho)
e=0 (mV)
v (mV)
mg = 1 (mM) : external magnesium concentration
}
ASSIGNED { i (nA) g (umho) }
LOCAL a[2]
LOCAL adjust
BREAKPOINT {
g = cond(t)*mgblock(v)
i = g*(v - e)
}
FUNCTION cond(x) {
adjust=(tau1/tau2)^(tau2/(tau2-tau1))-(tau1-tau2)^(tau1/(tau2-tau1))
if (x < onset) {
cond = 0
}else{
a[0]=exp(-(x-onset)/tau1)
a[1]=exp(-(x-onset)/tau2)
cond = gmax*(a[0]-a[1])/adjust
}
}
FUNCTION mgblock(v) {
TABLE
DEPEND mg
FROM -140 TO 80 WITH 1000
: from Jahr & Stevens
mgblock = 1 / (1 + exp(0.062 (/mV) * -v) * (mg / 3.57 (mM)))
}