# Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models **Kumar, A., Shahul, A. K., & Bhalla, U. S. (2025). Mechanisms and implications of high depolarization baseline offsets in conductance-based neuronal models. *Journal of Neurophysiology*. doi:10.1152/jn.00617.2024** ## Requirements 1. A debian based linux system such as Ubuntu or Linux mint. All codes will work on WSL in Windows too. Other systems were not tested. 2. python3.8-3.12. Not tested on other python versions. 3. [pymoose](https://github.com/BhallaLab/moose-core) (must be built from source by following the instructions) 4. [NEURON with python support](https://nrn.readthedocs.io/en/8.2.6/) ### Requirements to regenerate data 5. [goMultiprocessing](https://github.com/analkumar2/parallelize-forloops) 6. [brute_curvefit](https://github.com/analkumar2/brute_curvefit) ## Folder descriptions - **expdata** - Contains raw experimental data - **Fig1-9, SuppFigS1** - Contains scripts to generate paper figures - **FigAbstract** - Abstract figure - **helperScripts** - Contains script to generate some data and utility scripts - **Kinetics** - Contains files that describe ion channel kinetics used in this study