This is the Readme for the model associated with the paper:

Sudhakar, S. K., Choi, T. J., & Ahmed, O. J. (2019). Biophysical Modeling Suggests Optimal Drug Combinations for Improving the Efficacy of GABA Agonists after Traumatic Brain Injuries. Journal of Neurotrauma, 36, 1–14. https://doi.org/10.1089/neu.2018.6065



File descriptions

PYR_template.hoc - Neuron template of Regular spiking (RS) neuron described in the paper

test_RS_fig_1a1.hoc - Test file to generate figure 1a (upper panel, current = 300 pA)
test_RS_fig_1a2.hoc - Test file to generate figure 1a (middle panel, current = 700 pA)
test_RS_fig_1a3.hoc - Test file to generate figure 1a (lower panel, current = 2700 pA)


How to run the model

Download all files to your computer and cd to the corresponding folder On the terminal, type "mknrndll (or nrnivmodl)" to complile the .mod files
If you need more help running NEURON on your platform please consult:
https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide
Type "nrngui test_model_RS.hoc" or " nrngui test_model_LR.hoc" to run the model

For accurate results, use a dt of 0.025 ms.

In case of any questions, please send an email to shyamk@umich.edu