TITLE HHMk channel
: Hodgkin Huxley Moore k channel Mod
NEURON {
SUFFIX HHkM
USEION k READ ek WRITE ik
RANGE gkbar, ik
GLOBAL inf
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
dt (ms)
gkbar=.036 (S/cm2)
ek = -77 (mV)
celsius = 16 (degC)
}
STATE {
n
}
ASSIGNED {
ik (mA/cm2)
inf
}
LOCAL fac
INITIAL {
rate(v*1(/mV))
n = inf
}
BREAKPOINT {
SOLVE states
ik = gkbar*n*n*n*n*n*n*(v - ek)
}
PROCEDURE states() { : exact when v held constant
rate(v*1(/mV))
n = n + fac*(inf - n)
VERBATIM
return 0;
ENDVERBATIM
}
UNITSOFF
FUNCTION alp(v(mV)) { LOCAL q10
v = -v - 65
q10 = 3^((celsius - 6.3)/10)
alp = q10 * .01*expM1(v + 10, 10)
}
FUNCTION bet(v(mV)) { LOCAL q10
v = -v - 65
q10 = 3^((celsius - 6.3)/10)
bet = q10 * .125*exp(v/80)
}
FUNCTION expM1(x,y) {
if (fabs(x/y) < 1e-6) {
expM1 = y*(1 - x/y/2)
}else{
expM1 = x/(exp(x/y) - 1)
}
}
PROCEDURE rate(v) {LOCAL a, b, tau :rest = -70
TABLE inf, fac DEPEND dt, celsius FROM -100 TO 100 WITH 200
a = alp(v) b=bet(v)
tau = 1/(a + b)
inf = a/(a + b)
fac = (1 - exp(-dt/tau))
}
UNITSON