TITLE HH sodium channel
: Hodgkin - Huxley squid sodium channel
NEURON {
SUFFIX HHna
USEION na READ ena WRITE ina
RANGE gnabar, ina
GLOBAL inf
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
celsius = 6.3 (degC)
dt (ms)
gnabar=.120 (S/cm2)
ena = 50 (mV)
}
STATE {
m h
}
ASSIGNED {
ina (mA/cm2)
inf[2]
}
LOCAL fac[2]
INITIAL {
rate(v*1(/mV))
m = inf[0]
h = inf[1]
}
BREAKPOINT {
SOLVE states
ina = gnabar*m*m*m*h*(v - ena)
}
PROCEDURE states() { : exact when v held constant
rate(v*1(/mV))
m = m + fac[0]*(inf[0] - m)
h = h + fac[1]*(inf[1] - h)
VERBATIM
return 0;
ENDVERBATIM
}
UNITSOFF
FUNCTION alp(v(mV),i) { LOCAL a,b,c,q10 :rest = -70 order m,h
v = -v - 65 :convert to hh convention
q10 = 3^((celsius - 6.3)/10)
if (i==0) {
alp = q10*.1*expM1(v + 25, 10)
}else if (i==1){
alp = q10*.07*exp(v/20)
}
}
FUNCTION bet(v,i) { LOCAL a,b,c,q10 :rest = -70 order m,h
v = -v - 65
q10 = 3^((celsius - 6.3)/10)
if (i==0) {
bet = q10* 4*exp(v/18)
}else if (i==1){
bet = q10*1/(exp(.1*v + 3) + 1)
}
}
FUNCTION expM1(x,y) {
if (fabs(x/y) < 1e-6) {
expM1 = y*(1 - x/y/2)
}else{
expM1 = x/(exp(x/y) - 1)
}
}
PROCEDURE rate(v) {LOCAL a, b, tau :rest = -70
TABLE inf, fac DEPEND dt, celsius FROM -100 TO 100 WITH 200
FROM i=0 TO 1 {
a = alp(v,i) b=bet(v,i)
tau = 1/(a + b)
inf[i] = a/(a + b)
fac[i] = (1 - exp(-dt/tau))
}
}
UNITSON