/* In this experiment we want to compare the simulation speed of our model with other classical models of NMDA
*/
load_file("nrngui.hoc")
load_file("params.hoc")
//fully activates cache efficiency
cvode.cache_efficient(1)
tstop = 4000
dt = .025
celsius = 23 //room temperature in Clarke08 experiment = ?
v_init = -65
// ------------------
create soma
access soma
//------------Voltage Clamp---------------------------
objref vc
vc = new VClamp(.5)
vc.dur[0] = tstop
vc.amp[0] = 40
//---------------------------------------------------
objref sNMDA, stim, nc
{sNMDA = new Exp5NMDA(.5) SynWeight = 0.18532 } // Our Model 2012
//{sNMDA = new NMDA10_1(.5) SynWeight = 0.039071} // Kampa et al, 2004 model
//{sNMDA = new NMDA10_2(.5) SynWeight = 0.018831} // Vargas-Caballero & Robinson, 2004 model
//{sNMDA = new NMDA16(.5) SynWeight = 0.018831} // Vargas-Caballero & Robinson, 2004 model
stim = new NetStim(.5)
stim.interval = 200 //ms (mean) time between spikes
stim.number = 20 //(average) number of spikes
stim.start = 1.53427 - 1 //ms (most likely) start time of first spike
stim.noise = 0 //---- range 0 to 1. Fractional randomness.
//0 deterministic, 1 intervals have negexp distribution.
nc = new NetCon(stim, sNMDA)
proc init_NMDA() {
nc.weight = SynWeight
nc.delay = 1
}
objref FinNMDA
FinNMDA = new FInitializeHandler(3,"init_NMDA()")
init()
//-------Graph----------------------
// objref iNMDA, vSoma
// iNMDA = new Graph()
// iNMDA.size(0,tstop,-5.5,2.5)
// iNMDA.addvar("sNMDA.i",3,0)
// iNMDA.save_name("graphList[0].")
// graphList[0].append(iNMDA)
// vSoma = new Graph()
// vSoma.size(0,tstop,-100,50)
// vSoma.addvar("soma.v(.5)",3,0)
// vSoma.save_name("graphList[0].")
// graphList[0].append(vSoma)
//-------------------------------------
x = startsw()
for i=1, 10 {
run()
}
print startsw() - x