TITLE calcium lVA channels for DA
COMMENT
LOWthreshold calcium channel (L-type)
ENDCOMMENT
UNITS {
(mM) = (milli/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(pS) =(picosiemens)
FARADAY = (faraday) (coulomb)
R = (k-mole) (joule/degC)
}
NEURON {
THREADSAFE
SUFFIX CAV13
USEION ca READ cai WRITE ica
RANGE gbar, iLCa, ica, gbar
GLOBAL qinf
}
PARAMETER {
v (mV)
dt (ms)
gbar = 2 (pS/microm2)
celsius
Vmid_ac =-31 (mV)
k_ac = 7 (mV)
iLCa=0
eca = 120 (mV)
cao = 2.0 (mM)
cai (mM)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
STATE {
q
}
ASSIGNED {
ica (mA/cm2)
qinf
qtau (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
iLCa = (gbar)*q*(v-eca)*0.0001
ica = iLCa
}
INITIAL {
settables(v)
q = qinf
}
DERIVATIVE states {
settables(v)
q' = (qinf-q)/qtau
}
PROCEDURE settables(v) { :Computes rate and other constants at current v.
:Call once from HOC to initialize inf at resting v.
TABLE qinf, qtau FROM -100 TO 100 WITH 400
:"q" L Ca activation system
qinf = 1.0/(1.0 + exp((Vmid_ac - v)/ k_ac))
qtau =1/((-0.20876*(v+39.26)/(exp(-(v+39.26)/4.111)-1)+(0.9444*exp(-(v+15.38)/224.1))))
}