//MouseLocomotionCPG_integrate.c
//Jessica Parker, November 20, 2021
//
//This is the main integration file. This uses the 8th order Runge-Kutta method to integrate the set of differential equations and then
//writes the solution to an output file.
#include "MouseLocomotionCPG.h"
int integrate(int run1, int run2, int run3, int run4, int run5, int run6, int nvar, double tf, double tint, double y[])
{
char file_name_string[100];
sprintf(file_name_string,"./data/Vall%i_%i_%i_%i_%i_%i.dat",run1,run2,run3,run4,run5,run6); //filename where simulation data is saved
//You may want to change the prefix of this name
//depending on which variables you want to save.
//In this example case, I am saving all variables.
//gsl stuff
const gsl_odeiv_step_type * T = gsl_odeiv_step_rk8pd; //choose integrator
gsl_odeiv_step * s = gsl_odeiv_step_alloc (T, nvar);
gsl_odeiv_control * c = gsl_odeiv_control_y_new (1e-8, 1e-9); //set tolerances
gsl_odeiv_evolve * e = gsl_odeiv_evolve_alloc (nvar);
// declare variables
double t, t1, ti, iLn, h;
int ii,nn,status,lnPts;
h = 1e-8; // set initial stepsize
t1 = tf; // set total integrate time for data
iLn=t1*(1.0/tint);
int ln2 = (int)iLn;
if (ln2 < iLn)
{
ln2 = ln2+1;
}
// allocate data matrix
gsl_matrix * Vs = gsl_matrix_alloc (ln2+1, nvar); //Set to nvar if you want to save all variables. Set to 2 if you only want to save voltages.
//or set to 10 if you want to save the select few that I have chosen below.
// make system using gsl options and system parameters
// this integrator does not use the Jacbion, so pass NULL in its place
gsl_odeiv_system sys = {func, NULL, nvar};
t=0; // reset time for convenience
// integrator takes very small steps, but i only care about what happens once per 0.0001 seconds.
for (ii = 0; ii <= iLn;ii++)
{
lnPts=ii;
ti = ii * t1 / iLn;
// use however many steps to move the next 0.0001 seconds
while (t < ti)
{
// take one step
status = gsl_odeiv_evolve_apply (e, c, s,&sys,&t, ti, &h,y);
if (y[7]<=0.0) //y[7] and yy[17] represent sodium concentration in this system
{ //which we cannot allow to become negative. Although these if statements
y[7]=1e-8; //are generally not triggered if the equations are written correctly.
}
if (status !=GSL_SUCCESS)
{
break;
}
if (h<1e-14)
{
h=1e-14;
}
}
//Only one of two code blocks, A and B, below should be uncommented.
//A: Use this if you want to save all variables
for (nn=0;nn<nvar;nn++)
{
gsl_matrix_set(Vs,ii,nn,y[nn]);
}
//B: Use this entire block to save a few important variables
/*gsl_matrix_set(Vs,ii,0,y[0]); //only uncomment these 2 lines if
gsl_matrix_set(Vs,ii,1,y[10]); //you only want to save voltage data
gsl_matrix_set(Vs,ii,2,y[3]); //hNaP1
gsl_matrix_set(Vs,ii,3,y[13]); //hNaP2
gsl_matrix_set(Vs,ii,4,y[6]); //hCaS1
gsl_matrix_set(Vs,ii,5,y[16]); //hCaS2
gsl_matrix_set(Vs,ii,6,y[7]); //[Na]i1
gsl_matrix_set(Vs,ii,7,y[17]); //[Na]i2
gsl_matrix_set(Vs,ii,8,y[8]); //mh-a1
gsl_matrix_set(Vs,ii,9,y[18]); //mh-a2*/
}
// write data to file
FILE * f1 = fopen(file_name_string,"wb");
gsl_matrix_fwrite (f1,Vs);
fclose (f1);
// free memory
gsl_odeiv_evolve_free (e);
gsl_odeiv_control_free (c);
gsl_odeiv_step_free (s);
gsl_matrix_free (Vs);
//Save last point.
char f_ipr[100];
sprintf(f_ipr,"./data/ip%i_%i_%i_%i_%i_%i.txt",run1,run2,run3,run4,run5,run6);
FILE * f_ip = fopen(f_ipr,"w+");
for (nn=0;nn<nvar;nn++)
{
fprintf(f_ip,"%14.14g\n", y[nn]);
}
fclose(f_ip);
printf("\n Current iteration: %i \n", run6);
printf("termino\n");
return 0;
}