NEURON
{
SUFFIX stp
USEION ca READ cai
RANGE TTINF, tauTT, fT, tauTC
}
UNITS
{
(nA) = (nanoamp)
(mV) = (millivolt)
(uS) = (microsiemens)
(molar) = (1/liter)
(mM) = (millimolar)
R = (k-mole) (joule/degC)
FARADAY = (faraday) (coulomb)
(mA) = (milliamp)
(S) = (siemens)
}
PARAMETER
{
TTINF=20 (mM) <1e-9,1e9> : Max terminal neurotranmitter concn.
tauTT=2000 (ms) <1e-9,1e9> : Replenishment rate of terminal NT
fT=2000 (/mM/mM/mM/ms) : Parameter governing NT release intensity
tauTC=0.001 (ms)
}
ASSIGNED
{
cai (mM)
}
STATE
{
TT (mM) : Terminal neurotransmitter concentration
TC (mM) : Cleft neurotransmitter concentration
}
INITIAL
{
TT = TTINF : All terminal neurotransmitters are available
TC = 0 : There is no NT in the cleft
}
BREAKPOINT
{
SOLVE states METHOD cnexp
}
DERIVATIVE states
{
TT'=(TTINF-TT)/tauTT - fT*TT*(cai-50e-6)*(cai-50e-6)*(cai-50e-6)
TC'=fT*TT*(cai-50e-6)*(cai-50e-6)*(cai-50e-6) - TC/tauTC
}