TITLE Ca-dependent potassium current (C-current)
COMMENT
*********************************************
reference: Yamada, Koch & Adams (1989)
Meth. in Neuronal Modeling, MIT press
found in: bullfrog sympathetic ganglion cells
*********************************************
Assembled for MyFirstNEURON by Arthur Houweling
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX iC
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gkbar, m_inf, tau_m, ik
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(mM) = (milli/liter)
}
PARAMETER {
v (mV)
celsius (degC)
dt (ms)
ek (mV)
cai (mM)
gkbar= 0.00345 (mho/cm2)
}
STATE {
m
}
ASSIGNED {
ik (mA/cm2)
tau_m (ms)
m_inf
tadj
}
BREAKPOINT {
SOLVE states :METHOD euler
ik = gkbar * m * (v - ek)
}
:DERIVATIVE states {
: rates(v,cai)
:
: m'= (m_inf-m) / tau_m
:}
PROCEDURE states() {
rates(v,cai)
m= m + (1-exp(-dt/tau_m))*(m_inf-m)
}
UNITSOFF
INITIAL {
tadj = 3^((celsius-23.5)/10)
rates(v,cai)
m = m_inf
}
PROCEDURE rates( v(mV), cai(mM)) { LOCAL a,b
a = 250 * cai * exp(v/24)
b = 0.1 * exp(-v/24)
tau_m = 1/(a+b) / tadj
m_inf = a/(a+b)
}
UNITSON