TITLE hh.mod squid sodium, potassium, and leak channels
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
NEURON {
SUFFIX hh
USEION na READ ena WRITE ina
USEION k READ ek WRITE ik
NONSPECIFIC_CURRENT il
RANGE gnabar, gkbar, gl, el, gna, gk
GLOBAL minf, hinf, ninf, mtau, htau, ntau
THREADSAFE : assigned GLOBALs will be per thread
}
PARAMETER {
gnabar = .12 (S/cm2) <0,1e9>
gkbar = .036 (S/cm2) <0,1e9>
gl = .0003 (S/cm2) <0,1e9>
el = -54.3 (mV)
}
STATE {
m h n
}
ASSIGNED {
v (mV)
celsius (degC)
ena (mV)
ek (mV)
gna (S/cm2)
gk (S/cm2)
ina (mA/cm2)
ik (mA/cm2)
il (mA/cm2)
minf hinf ninf
mtau (ms) htau (ms) ntau (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
gna = gnabar*m*m*m*h
ina = gna*(v - ena)
gk = gkbar*n*n*n*n
ik = gk*(v - ek)
il = gl*(v - el)
}
INITIAL {
rates(v)
m = minf
h = hinf
n = ninf
}
DERIVATIVE states {
rates(v)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
n' = (ninf-n)/ntau
}
PROCEDURE rates(v(mV)) {
LOCAL alpha, beta, sum, q10
TABLE minf, mtau, hinf, htau, ninf, ntau DEPEND celsius FROM -100 TO 100 WITH 200
UNITSOFF
q10 = 3^((celsius - 6.3)/10)
alpha = .1 * vtrap(-(v+40),10)
beta = 4 * exp(-(v+65)/18)
sum = alpha + beta
mtau = 1/(q10*sum)
minf = alpha/sum
alpha = .07 * exp(-(v+65)/20)
beta = 1 / (exp(-(v+35)/10) + 1)
sum = alpha + beta
htau = 1/(q10*sum)
hinf = alpha/sum
alpha = .01*vtrap(-(v+55),10)
beta = .125*exp(-(v+65)/80)
sum = alpha + beta
ntau = 1/(q10*sum)
ninf = alpha/sum
}
FUNCTION vtrap(x,y) {
if (fabs(x/y) < 1e-6) {
vtrap = y*(1 - x/y/2)
}else{
vtrap = x/(exp(x/y) - 1)
}
}
UNITSON