TITLE kir
COMMENT
potassium inward rectifier after geukes foppen en siegenbeek
simply, with no time dynamics. (instantanous kinetics)
ENDCOMMENT
NEURON {
SUFFIX kir
USEION na READ nao
USEION k READ ko, ek WRITE ik
USEION cl READ clo VALENCE -1
RANGE gbar, ik, qk
GLOBAL vs
}
UNITS {
(molar) = (1/liter)
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (millimolar)
:FARADAY = (faraday) (coulomb)
FARADAY = 96485.309 (coul)
R = (k-mole) (joule/degC)
PI = (pi) (1)
}
STATE { qk }
PARAMETER {
gbar = 0 (mho/cm2)
vs = 1 :voltage-dependency factor in boltzmann equation was 4
vh = 0 (mV) :halfmaximal activation relative to ek was -10
}
ASSIGNED {
ik (mA/cm2)
v (mV)
ek (mV)
ko (mM)
nao (mM)
clo (mM)
diam (um)
}
BREAKPOINT {
ik = gbar*pkir((v), ko, ek)*(v-ek)
SOLVE kaccum METHOD sparse
}
KINETIC kaccum {
COMPARTMENT diam*diam*PI/4 { qna qk }
~ qk << ( -ik*PI*diam*(1e4)/FARADAY)
}
FUNCTION pkir(vm,kout,erev) {
pkir = 1 / ( sqrt(kout) * (1+exp((vm-vh-erev)/vs)) )
}