from moose_nerp.prototypes.util import NamedList, NamedDict
from moose_nerp.prototypes.syn_proto import SynChannelParams, MgParams, DesensitizationParams
from . import param_cond
#Parameters for inhibitory synpases:
#Erev, tau1, tau2 (SI units)
#C is concentration of Mg, A is 1/eta and B is 1/gamma,
#Rebekah's:
#These params are too insensitive to voltage
#mgparams={'A':(1/18.0), 'B':(1/99.0), 'C': 1.4}
#Classic (allows significant calcium at resting potential):
#mgparams={'A':(1/3.57), 'B':(1/62.0), 'C': 1.4}
#Intermediate
desenYN = 0
_NMDA_MgParams = MgParams(A = 1/18.0,#3.57,#18.0,
B = 1/99.0,#62.0,#99.0,
C = 1.0)
#Sriram uses 0.109e-9 for AMPA and 0.9e-9 for Gaba
_SynGaba = SynChannelParams(Erev = -60e-3,
tau1 = 0.25e-3,
tau2 = 3.75e-3,
Gbar = 0.2e-9,
nmdaCaFrac = 0.0,
var=0.05)
SynGabaNPY = SynChannelParams(Erev = -60e-3, #NPY
tau1 = 0.25e-3,
tau2 = 80.75e-3,
Gbar = 0.5e-9,
nmdaCaFrac = 0.0,
var=0.05)
_SynAMPA = SynChannelParams(Erev = 5e-3,
tau1 = 1.1e-3*2,
tau2 = 2.0e-3*2,
Gbar = 5e-9,
var=0.05,
nmdaCaFrac = 0.001,
spinic = 2)
_SynNMDA = SynChannelParams(Erev = 5e-3,
tau1 = 2.23e-3*2,
tau2 = 56.25e-3*5,
Gbar = 1e-9,
var=0,#0.05,
MgBlock = _NMDA_MgParams,
spinic = 2,
NMDA=True,
nmdaCaFrac = 0.05,
)
#spinic: False or absent - do not add to spines
# True of 1 - add to spines if present, o.w. dendrites
# 2 - add to spines only
#nmdaCaFra fraction of nmda current carried by calcium
#Note that since Ca reversal produces ~2x driving potential,
#need to make this half of typical value. Default is 0.02 in Moose
SYNAPSE_TYPES = NamedDict(
'SYNAPSE_TYPES',
ampa = _SynAMPA,
gaba = _SynGaba,
nmda = _SynNMDA,
)
DesensitizationParams = NamedDict('Synapse_desensitization',gaba = None, nmda=None, ampa=DesensitizationParams(dep_per_spike=0.39,dep_tau=0.8))
#These will be used by synconn in connect.py, since AMPA and NMDA synapses usually go together
#for same reason, the next lines only list ampa and gaba, and nmda are created the same as ampa
NAME_AMPA='ampa'
NAME_NMDA='nmda'
# number of synapses at each distance
_gaba = {param_cond.prox:4, param_cond.med:4, param_cond.dist:4}
_ampa= {param_cond.prox:1, param_cond.med:2, param_cond.dist:3}
NumSyn={'gaba':_gaba,
'ampa':_ampa}