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<celldesigner:protein id="pr46" name="Neutrophills" type="GENERIC"/>
<celldesigner:protein id="pr47" name="IFNγ " type="GENERIC"/>
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<celldesigner:protein id="pr51" name="MCP-1" type="GENERIC"/>
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<celldesigner:listOfLayers/>
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<rdf:Description rdf:about="#CDMT00074">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
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<species metaid="s87" id="s87" name="Macrophage" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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</annotation>
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</annotation>
</species>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
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</annotation>
</species>
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</annotation>
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</annotation>
</species>
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</celldesigner:speciesIdentity>
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</annotation>
</species>
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</species>
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<annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00076">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re80 </ci>
<ci> kmc_re80_s30 </ci>
</apply>
<ci> s30 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re80 </ci>
<ci> kmc_re80_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s30 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s30 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re80" id="vmaf_re80" name="Forward maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s30" id="kmc_re80_s30" name="Michaelis constant of species type 2 pneumocytes in reaction re80" value="1" units="substance"/>
<parameter metaid="vmar_re80" id="vmar_re80" name="Revere maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s1" id="kmc_re80_s1" name="Michaelis constant of species Degradation in reaction re80" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re83" id="re81" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa60">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s96" alias="sa58">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00178" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00179" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00077">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re81 </ci>
<ci> kmc_re81_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re81 </ci>
<ci> kmc_re81_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s96 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re81" id="vmaf_re81" name="Forward maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s1" id="kmc_re81_s1" name="Michaelis constant of species Degradation in reaction re81" value="1" units="substance"/>
<parameter metaid="vmar_re81" id="vmar_re81" name="Revere maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s96" id="kmc_re81_s96" name="Michaelis constant of species DAMPs in reaction re81" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re40" id="re82" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa51">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7513002927440269,0.4280183852877535</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00180" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00181" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00078">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re82 </ci>
<ci> kmc_re82_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re82 </ci>
<ci> kmc_re82_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re82" id="vmaf_re82" name="Forward maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s96" id="kmc_re82_s96" name="Michaelis constant of species DAMPs in reaction re82" value="1" units="substance"/>
<parameter metaid="vmar_re82" id="vmar_re82" name="Revere maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s86" id="kmc_re82_s86" name="Michaelis constant of species T cells in reaction re82" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re41" id="re83" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa63">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9242914473016368,0.2532768539185204</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00182" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00183" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00079">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re83 </ci>
<ci> kmc_re83_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re83 </ci>
<ci> kmc_re83_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re83" id="vmaf_re83" name="Forward maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s96" id="kmc_re83_s96" name="Michaelis constant of species DAMPs in reaction re83" value="1" units="substance"/>
<parameter metaid="vmar_re83" id="vmar_re83" name="Revere maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s2" id="kmc_re83_s2" name="Michaelis constant of species Dendritic cells in reaction re83" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re42" id="re84" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s88" alias="sa53">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9774468681158912,0.16645818519385092</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00184" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00185" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00080">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re84 </ci>
<ci> kmc_re84_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re84 </ci>
<ci> kmc_re84_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s88 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re84" id="vmaf_re84" name="Forward maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s96" id="kmc_re84_s96" name="Michaelis constant of species DAMPs in reaction re84" value="1" units="substance"/>
<parameter metaid="vmar_re84" id="vmar_re84" name="Revere maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s88" id="kmc_re84_s88" name="Michaelis constant of species Neutrophills in reaction re84" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re43" id="re85" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa52">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9824604344806578,0.11846715292237686</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00186" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00187" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00081">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re85 </ci>
<ci> kmc_re85_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re85 </ci>
<ci> kmc_re85_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re85" id="vmaf_re85" name="Forward maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s96" id="kmc_re85_s96" name="Michaelis constant of species DAMPs in reaction re85" value="1" units="substance"/>
<parameter metaid="vmar_re85" id="vmar_re85" name="Revere maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s87" id="kmc_re85_s87" name="Michaelis constant of species Macrophage in reaction re85" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="CDMT00100" id="re86" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s84" alias="sa50">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00188" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00189" species="s84">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00082">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re86 </ci>
<ci> kmc_re86_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re86 </ci>
<ci> kmc_re86_s84 </ci>
</apply>
<ci> s84 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s84 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re86" id="vmaf_re86" name="Forward maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s96" id="kmc_re86_s96" name="Michaelis constant of species DAMPs in reaction re86" value="1" units="substance"/>
<parameter metaid="vmar_re86" id="vmar_re86" name="Revere maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s84" id="kmc_re86_s84" name="Michaelis constant of species NLRP3 in reaction re86" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="CDMT00103" id="re87" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s84" alias="sa50">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.19789290685233407,-0.1435026941895019 0.5622320589828105,0.32670703372999</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s85" aliases="sa62" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s85" alias="sa62">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00190" species="s84">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00191" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00001" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00002">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> kcat_re87_s85 </ci>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<apply>
<plus/>
<ci> kmc_re87_s84_s85 </ci>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="kcat_re87_s85" id="kcat_re87_s85" name="Substrate catalytic rate constant of enzyme NFkB in reaction re87" value="1" units="per_second"/>
<parameter metaid="kmc_re87_s84_s85" id="kmc_re87_s84_s85" name="Michaelis constant of species NLRP3 and enzyme NFkB in reaction re87" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re47" id="re88" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s84" alias="sa50">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa59">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.05550299276170145,-0.09859398969283095 0.8302728617015878,0.3179439646859956</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00192" species="s84">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00193" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00084">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re88 </ci>
<ci> kmc_re88_s84 </ci>
</apply>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re88 </ci>
<ci> kmc_re88_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s84 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re88" id="vmaf_re88" name="Forward maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s84" id="kmc_re88_s84" name="Michaelis constant of species NLRP3 in reaction re88" value="1" units="substance"/>
<parameter metaid="vmar_re88" id="vmar_re88" name="Revere maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s101" id="kmc_re88_s101" name="Michaelis constant of species IL-18 in reaction re88" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re50" id="re89" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa58">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s97" alias="sa61">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.02517007318723552,-0.15830210374003784</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00194" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00195" species="s97">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa61</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00085">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re89 </ci>
<ci> kmc_re89_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re89 </ci>
<ci> kmc_re89_s97 </ci>
</apply>
<ci> s97 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s97 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re89" id="vmaf_re89" name="Forward maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s96" id="kmc_re89_s96" name="Michaelis constant of species DAMPs in reaction re89" value="1" units="substance"/>
<parameter metaid="vmar_re89" id="vmar_re89" name="Revere maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s97" id="kmc_re89_s97" name="Michaelis constant of species TLR in reaction re89" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re51" id="re90" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.12481303954254308,-0.030011405669947866 0.4786555054375565,0.10980364015971289</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00196" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00197" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00086">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re90 </ci>
<ci> kmc_re90_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re90 </ci>
<ci> kmc_re90_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re90" id="vmaf_re90" name="Forward maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s86" id="kmc_re90_s86" name="Michaelis constant of species T cells in reaction re90" value="1" units="substance"/>
<parameter metaid="vmar_re90" id="vmar_re90" name="Revere maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s33" id="kmc_re90_s33" name="Michaelis constant of species IL-1β in reaction re90" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re52" id="re91" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00198" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00199" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00087">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re91 </ci>
<ci> kmc_re91_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re91 </ci>
<ci> kmc_re91_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re91" id="vmaf_re91" name="Forward maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s86" id="kmc_re91_s86" name="Michaelis constant of species T cells in reaction re91" value="1" units="substance"/>
<parameter metaid="vmar_re91" id="vmar_re91" name="Revere maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s35" id="kmc_re91_s35" name="Michaelis constant of species TNFα in reaction re91" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re53" id="re92" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa59">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.045979046633489506,-0.042911992718993375 0.37110088601999447,-0.0781355215821371 0.6853960169043116,0.27736122698516374</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00200" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00201" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00088">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re92 </ci>
<ci> kmc_re92_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re92 </ci>
<ci> kmc_re92_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re92_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re92_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re92" id="vmaf_re92" name="Forward maximal velocity of reaction re92" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re92_s86" id="kmc_re92_s86" name="Michaelis constant of species T cells in reaction re92" value="1" units="substance"/>
<parameter metaid="vmar_re92" id="vmar_re92" name="Revere maximal velocity of reaction re92" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re92_s101" id="kmc_re92_s101" name="Michaelis constant of species IL-18 in reaction re92" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re114" id="re93" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa48">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.05208310029519936,-0.02650395265573391 0.4752381206960008,0.013513850927383886 0.5954203692101636,0.22373257104760536</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00202" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00203" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00089">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re93 </ci>
<ci> kmc_re93_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re93 </ci>
<ci> kmc_re93_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re93_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re93_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re93" id="vmaf_re93" name="Forward maximal velocity of reaction re93" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re93_s86" id="kmc_re93_s86" name="Michaelis constant of species T cells in reaction re93" value="1" units="substance"/>
<parameter metaid="vmar_re93" id="vmar_re93" name="Revere maximal velocity of reaction re93" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re93_s34" id="kmc_re93_s34" name="Michaelis constant of species IL-6 in reaction re93" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re55" id="re94" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa52">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.31172239571518334,0.18508429422638617 0.5805393263738963,-0.2624703246472224</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00204" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00205" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00090">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re94 </ci>
<ci> kmc_re94_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re94 </ci>
<ci> kmc_re94_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re94_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re94_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re94" id="vmaf_re94" name="Forward maximal velocity of reaction re94" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re94_s87" id="kmc_re94_s87" name="Michaelis constant of species Macrophage in reaction re94" value="1" units="substance"/>
<parameter metaid="vmar_re94" id="vmar_re94" name="Revere maximal velocity of reaction re94" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re94_s33" id="kmc_re94_s33" name="Michaelis constant of species IL-1β in reaction re94" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re57" id="re95" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa52">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa48">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.344485288952983,0.07746817659368066 0.39247604675830683,-0.1413197394334489</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00206" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00207" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00091">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re95 </ci>
<ci> kmc_re95_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re95 </ci>
<ci> kmc_re95_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re95_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re95_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re95" id="vmaf_re95" name="Forward maximal velocity of reaction re95" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re95_s87" id="kmc_re95_s87" name="Michaelis constant of species Macrophage in reaction re95" value="1" units="substance"/>
<parameter metaid="vmar_re95" id="vmar_re95" name="Revere maximal velocity of reaction re95" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re95_s34" id="kmc_re95_s34" name="Michaelis constant of species IL-6 in reaction re95" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re58" id="re96" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa52">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.28288276732701545,0.23926523255146392 0.6998797155820219,-0.2520663416580291</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00208" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00209" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00092">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re96 </ci>
<ci> kmc_re96_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re96 </ci>
<ci> kmc_re96_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re96_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re96_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re96" id="vmaf_re96" name="Forward maximal velocity of reaction re96" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re96_s87" id="kmc_re96_s87" name="Michaelis constant of species Macrophage in reaction re96" value="1" units="substance"/>
<parameter metaid="vmar_re96" id="vmar_re96" name="Revere maximal velocity of reaction re96" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re96_s35" id="kmc_re96_s35" name="Michaelis constant of species TNFα in reaction re96" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re59" id="re97" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa63">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2930646014892657,0.3875107446507311 0.30477865769928236,-0.027079488865161316</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00210" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00211" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00093">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re97 </ci>
<ci> kmc_re97_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re97 </ci>
<ci> kmc_re97_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re97_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re97_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re97" id="vmaf_re97" name="Forward maximal velocity of reaction re97" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re97_s2" id="kmc_re97_s2" name="Michaelis constant of species Dendritic cells in reaction re97" value="1" units="substance"/>
<parameter metaid="vmar_re97" id="vmar_re97" name="Revere maximal velocity of reaction re97" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re97_s33" id="kmc_re97_s33" name="Michaelis constant of species IL-1β in reaction re97" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re60" id="re98" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa63">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa48">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.396407327558685,0.23057772789323627</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00212" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00213" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re98 </ci>
<ci> kmc_re98_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re98 </ci>
<ci> kmc_re98_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re98_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re98_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re98" id="vmaf_re98" name="Forward maximal velocity of reaction re98" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re98_s2" id="kmc_re98_s2" name="Michaelis constant of species Dendritic cells in reaction re98" value="1" units="substance"/>
<parameter metaid="vmar_re98" id="vmar_re98" name="Revere maximal velocity of reaction re98" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re98_s34" id="kmc_re98_s34" name="Michaelis constant of species IL-6 in reaction re98" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re61" id="re99" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa63">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.16367103372068303,0.3846789879897039 0.32052345232405344,-0.18775985018551777</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00214" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00215" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00095">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re99 </ci>
<ci> kmc_re99_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re99 </ci>
<ci> kmc_re99_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re99_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re99_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re99" id="vmaf_re99" name="Forward maximal velocity of reaction re99" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re99_s2" id="kmc_re99_s2" name="Michaelis constant of species Dendritic cells in reaction re99" value="1" units="substance"/>
<parameter metaid="vmar_re99" id="vmar_re99" name="Revere maximal velocity of reaction re99" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re99_s35" id="kmc_re99_s35" name="Michaelis constant of species TNFα in reaction re99" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re62" id="re100" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa53">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4429765469732234,0.22161424169710653 0.6421904507972549,-0.17612604475167526</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00216" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00217" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00096">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re100 </ci>
<ci> kmc_re100_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re100 </ci>
<ci> kmc_re100_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re100_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re100_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re100" id="vmaf_re100" name="Forward maximal velocity of reaction re100" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re100_s88" id="kmc_re100_s88" name="Michaelis constant of species Neutrophills in reaction re100" value="1" units="substance"/>
<parameter metaid="vmar_re100" id="vmar_re100" name="Revere maximal velocity of reaction re100" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re100_s35" id="kmc_re100_s35" name="Michaelis constant of species TNFα in reaction re100" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re63" id="re101" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa53">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<kineticLaw metaid="CDMT00097">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re101 </ci>
<ci> kmc_re101_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re101 </ci>
<ci> kmc_re101_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re101_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re101_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re101" id="vmaf_re101" name="Forward maximal velocity of reaction re101" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re101_s88" id="kmc_re101_s88" name="Michaelis constant of species Neutrophills in reaction re101" value="1" units="substance"/>
<parameter metaid="vmar_re101" id="vmar_re101" name="Revere maximal velocity of reaction re101" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re101_s33" id="kmc_re101_s33" name="Michaelis constant of species IL-1β in reaction re101" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00098">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re102 </ci>
<ci> kmc_re102_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re102 </ci>
<ci> kmc_re102_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re102_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re102_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re102" id="vmaf_re102" name="Forward maximal velocity of reaction re102" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re102_s88" id="kmc_re102_s88" name="Michaelis constant of species Neutrophills in reaction re102" value="1" units="substance"/>
<parameter metaid="vmar_re102" id="vmar_re102" name="Revere maximal velocity of reaction re102" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re102_s3" id="kmc_re102_s3" name="Michaelis constant of species IL-12 in reaction re102" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re65" id="re103" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa53">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa57">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00222" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00223" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re103 </ci>
<ci> kmc_re103_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re103 </ci>
<ci> kmc_re103_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re103_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re103_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re103" id="vmaf_re103" name="Forward maximal velocity of reaction re103" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re103_s88" id="kmc_re103_s88" name="Michaelis constant of species Neutrophills in reaction re103" value="1" units="substance"/>
<parameter metaid="vmar_re103" id="vmar_re103" name="Revere maximal velocity of reaction re103" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re103_s94" id="kmc_re103_s94" name="Michaelis constant of species MCP-1 in reaction re103" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re66" id="re104" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa63">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa64">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.16776142999000498,0.14856265799590496</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00224" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00225" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00101">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re104 </ci>
<ci> kmc_re104_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re104 </ci>
<ci> kmc_re104_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re104_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re104_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re104" id="vmaf_re104" name="Forward maximal velocity of reaction re104" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re104_s2" id="kmc_re104_s2" name="Michaelis constant of species Dendritic cells in reaction re104" value="1" units="substance"/>
<parameter metaid="vmar_re104" id="vmar_re104" name="Revere maximal velocity of reaction re104" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re104_s3" id="kmc_re104_s3" name="Michaelis constant of species IL-12 in reaction re104" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re67" id="re105" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa52">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa64">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.49039882092538667,0.2004643518946576 0.6351372620162432,-0.14927534629732353</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00226" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00227" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00102">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re105 </ci>
<ci> kmc_re105_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re105 </ci>
<ci> kmc_re105_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re105_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re105_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re105" id="vmaf_re105" name="Forward maximal velocity of reaction re105" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re105_s87" id="kmc_re105_s87" name="Michaelis constant of species Macrophage in reaction re105" value="1" units="substance"/>
<parameter metaid="vmar_re105" id="vmar_re105" name="Revere maximal velocity of reaction re105" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re105_s3" id="kmc_re105_s3" name="Michaelis constant of species IL-12 in reaction re105" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re68" id="re106" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s93" alias="sa56">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<speciesReference metaid="CDMT00228" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00229" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa56</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00104">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re106 </ci>
<ci> kmc_re106_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re106 </ci>
<ci> kmc_re106_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re106_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re106_s93 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re106" id="vmaf_re106" name="Forward maximal velocity of reaction re106" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re106_s86" id="kmc_re106_s86" name="Michaelis constant of species T cells in reaction re106" value="1" units="substance"/>
<parameter metaid="vmar_re106" id="vmar_re106" name="Revere maximal velocity of reaction re106" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re106_s93" id="kmc_re106_s93" name="Michaelis constant of species IL-2 in reaction re106" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re69" id="re107" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa54">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00230" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00231" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00105">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re107 </ci>
<ci> kmc_re107_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re107 </ci>
<ci> kmc_re107_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re107_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re107_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re107" id="vmaf_re107" name="Forward maximal velocity of reaction re107" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re107_s86" id="kmc_re107_s86" name="Michaelis constant of species T cells in reaction re107" value="1" units="substance"/>
<parameter metaid="vmar_re107" id="vmar_re107" name="Revere maximal velocity of reaction re107" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re107_s89" id="kmc_re107_s89" name="Michaelis constant of species IFNγ  in reaction re107" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re70" id="re108" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.8704891373461017,0.3468456063550658</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00232" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00233" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00106">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re108 </ci>
<ci> kmc_re108_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re108 </ci>
<ci> kmc_re108_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re108_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re108_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re108" id="vmaf_re108" name="Forward maximal velocity of reaction re108" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re108_s85" id="kmc_re108_s85" name="Michaelis constant of species NFkB in reaction re108" value="1" units="substance"/>
<parameter metaid="vmar_re108" id="vmar_re108" name="Revere maximal velocity of reaction re108" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re108_s35" id="kmc_re108_s35" name="Michaelis constant of species TNFα in reaction re108" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re71" id="re109" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa47">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9208320216167953,0.26155430611243347</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00234" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00235" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00107">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re109 </ci>
<ci> kmc_re109_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re109 </ci>
<ci> kmc_re109_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re109_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re109_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re109" id="vmaf_re109" name="Forward maximal velocity of reaction re109" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re109_s85" id="kmc_re109_s85" name="Michaelis constant of species NFkB in reaction re109" value="1" units="substance"/>
<parameter metaid="vmar_re109" id="vmar_re109" name="Revere maximal velocity of reaction re109" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re109_s33" id="kmc_re109_s33" name="Michaelis constant of species IL-1β in reaction re109" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re72" id="re110" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s93" alias="sa56">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9911221263094736,0.09342507385808663</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00236" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00237" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa56</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00108">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re110 </ci>
<ci> kmc_re110_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re110 </ci>
<ci> kmc_re110_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re110_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re110_s93 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re110" id="vmaf_re110" name="Forward maximal velocity of reaction re110" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re110_s85" id="kmc_re110_s85" name="Michaelis constant of species NFkB in reaction re110" value="1" units="substance"/>
<parameter metaid="vmar_re110" id="vmar_re110" name="Revere maximal velocity of reaction re110" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re110_s93" id="kmc_re110_s93" name="Michaelis constant of species IL-2 in reaction re110" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re73" id="re111" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa54">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7849677398663388,0.42870876104545985</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00238" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00239" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00109">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re111 </ci>
<ci> kmc_re111_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re111 </ci>
<ci> kmc_re111_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re111_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re111_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re111" id="vmaf_re111" name="Forward maximal velocity of reaction re111" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re111_s85" id="kmc_re111_s85" name="Michaelis constant of species NFkB in reaction re111" value="1" units="substance"/>
<parameter metaid="vmar_re111" id="vmar_re111" name="Revere maximal velocity of reaction re111" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re111_s89" id="kmc_re111_s89" name="Michaelis constant of species IFNγ  in reaction re111" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re74" id="re112" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa64">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9384087250916342,0.24310181464522973</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00240" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00241" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00110">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re112 </ci>
<ci> kmc_re112_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re112 </ci>
<ci> kmc_re112_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re112_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re112_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re112" id="vmaf_re112" name="Forward maximal velocity of reaction re112" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re112_s85" id="kmc_re112_s85" name="Michaelis constant of species NFkB in reaction re112" value="1" units="substance"/>
<parameter metaid="vmar_re112" id="vmar_re112" name="Revere maximal velocity of reaction re112" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re112_s3" id="kmc_re112_s3" name="Michaelis constant of species IL-12 in reaction re112" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re75" id="re113" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s97" alias="sa61">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00242" species="s97">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa61</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00243" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00111">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re113 </ci>
<ci> kmc_re113_s97 </ci>
</apply>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re113 </ci>
<ci> kmc_re113_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re113_s97 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re113_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re113" id="vmaf_re113" name="Forward maximal velocity of reaction re113" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re113_s97" id="kmc_re113_s97" name="Michaelis constant of species TLR in reaction re113" value="1" units="substance"/>
<parameter metaid="vmar_re113" id="vmar_re113" name="Revere maximal velocity of reaction re113" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re113_s85" id="kmc_re113_s85" name="Michaelis constant of species NFkB in reaction re113" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re78" id="re114" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa60">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s6" alias="sa65">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00244" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00245" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa65</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00112">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re114 </ci>
<ci> kmc_re114_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re114 </ci>
<ci> kmc_re114_s6 </ci>
</apply>
<ci> s6 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re114_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re114_s6 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re114" id="vmaf_re114" name="Forward maximal velocity of reaction re114" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re114_s1" id="kmc_re114_s1" name="Michaelis constant of species Degradation in reaction re114" value="1" units="substance"/>
<parameter metaid="vmar_re114" id="vmar_re114" name="Revere maximal velocity of reaction re114" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re114_s6" id="kmc_re114_s6" name="Michaelis constant of species ROS in reaction re114" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re79" id="re115" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s6" alias="sa65">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00246" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa65</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00247" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00113">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re115 </ci>
<ci> kmc_re115_s6 </ci>
</apply>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re115 </ci>
<ci> kmc_re115_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re115_s6 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re115_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re115" id="vmaf_re115" name="Forward maximal velocity of reaction re115" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re115_s6" id="kmc_re115_s6" name="Michaelis constant of species ROS in reaction re115" value="1" units="substance"/>
<parameter metaid="vmar_re115" id="vmar_re115" name="Revere maximal velocity of reaction re115" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re115_s85" id="kmc_re115_s85" name="Michaelis constant of species NFkB in reaction re115" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re139" id="re116" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa57">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00248" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00249" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00114">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re116 </ci>
<ci> kmc_re116_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re116 </ci>
<ci> kmc_re116_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re116_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re116_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re116" id="vmaf_re116" name="Forward maximal velocity of reaction re116" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re116_s86" id="kmc_re116_s86" name="Michaelis constant of species T cells in reaction re116" value="1" units="substance"/>
<parameter metaid="vmar_re116" id="vmar_re116" name="Revere maximal velocity of reaction re116" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re116_s94" id="kmc_re116_s94" name="Michaelis constant of species MCP-1 in reaction re116" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re140" id="re117" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa51">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s102" alias="sa66">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.330419047925818,-0.3487645469852034 0.8606517730707379,0.14775951503774198</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00250" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00251" species="s102">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa66</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00115">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re117 </ci>
<ci> kmc_re117_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re117 </ci>
<ci> kmc_re117_s102 </ci>
</apply>
<ci> s102 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re117_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s102 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re117_s102 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re117" id="vmaf_re117" name="Forward maximal velocity of reaction re117" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re117_s86" id="kmc_re117_s86" name="Michaelis constant of species T cells in reaction re117" value="1" units="substance"/>
<parameter metaid="vmar_re117" id="vmar_re117" name="Revere maximal velocity of reaction re117" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re117_s102" id="kmc_re117_s102" name="Michaelis constant of species IL-21 in reaction re117" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re141" id="re118" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa57">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.983869521093232,0.12554083978606867</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00252" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00253" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00116">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re118 </ci>
<ci> kmc_re118_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re118 </ci>
<ci> kmc_re118_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re118_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re118_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re118" id="vmaf_re118" name="Forward maximal velocity of reaction re118" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re118_s85" id="kmc_re118_s85" name="Michaelis constant of species NFkB in reaction re118" value="1" units="substance"/>
<parameter metaid="vmar_re118" id="vmar_re118" name="Revere maximal velocity of reaction re118" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re118_s94" id="kmc_re118_s94" name="Michaelis constant of species MCP-1 in reaction re118" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re142" id="re119" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa62">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa59">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9862772438075726,0.11831298068702711</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00254" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00255" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00117">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re119 </ci>
<ci> kmc_re119_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re119 </ci>
<ci> kmc_re119_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re119_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re119_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re119" id="vmaf_re119" name="Forward maximal velocity of reaction re119" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re119_s85" id="kmc_re119_s85" name="Michaelis constant of species NFkB in reaction re119" value="1" units="substance"/>
<parameter metaid="vmar_re119" id="vmar_re119" name="Revere maximal velocity of reaction re119" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re119_s101" id="kmc_re119_s101" name="Michaelis constant of species IL-18 in reaction re119" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re143" id="re120" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa49">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.1302499879270549,0.2764150702447825 0.6625088260324361,0.6715436490499815</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00256" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00257" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00118">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re120 </ci>
<ci> kmc_re120_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re120 </ci>
<ci> kmc_re120_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re120_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re120_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re120" id="vmaf_re120" name="Forward maximal velocity of reaction re120" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re120_s35" id="kmc_re120_s35" name="Michaelis constant of species TNFα in reaction re120" value="1" units="substance"/>
<parameter metaid="vmar_re120" id="vmar_re120" name="Revere maximal velocity of reaction re120" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re120_s85" id="kmc_re120_s85" name="Michaelis constant of species NFkB in reaction re120" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re144" id="re121" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s33" alias="sa47">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.11892450895595008,0.3372519986490303 0.7525179685758507,0.6622726757453936</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00258" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00259" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00119">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re121 </ci>
<ci> kmc_re121_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re121 </ci>
<ci> kmc_re121_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re121_s33 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re121_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re121" id="vmaf_re121" name="Forward maximal velocity of reaction re121" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re121_s33" id="kmc_re121_s33" name="Michaelis constant of species IL-1β in reaction re121" value="1" units="substance"/>
<parameter metaid="vmar_re121" id="vmar_re121" name="Revere maximal velocity of reaction re121" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re121_s85" id="kmc_re121_s85" name="Michaelis constant of species NFkB in reaction re121" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re146" id="re123" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa67">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa63">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00263" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00121">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re123 </ci>
<ci> kmc_re123_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re123 </ci>
<ci> kmc_re123_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re123_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re123_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re123" id="vmaf_re123" name="Forward maximal velocity of reaction re123" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re123_s103" id="kmc_re123_s103" name="Michaelis constant of species NK cells in reaction re123" value="1" units="substance"/>
<parameter metaid="vmar_re123" id="vmar_re123" name="Revere maximal velocity of reaction re123" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re123_s2" id="kmc_re123_s2" name="Michaelis constant of species Dendritic cells in reaction re123" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00264" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00265" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00122">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re124 </ci>
<ci> kmc_re124_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re124 </ci>
<ci> kmc_re124_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re124_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re124_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re124" id="vmaf_re124" name="Forward maximal velocity of reaction re124" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re124_s103" id="kmc_re124_s103" name="Michaelis constant of species NK cells in reaction re124" value="1" units="substance"/>
<parameter metaid="vmar_re124" id="vmar_re124" name="Revere maximal velocity of reaction re124" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re124_s87" id="kmc_re124_s87" name="Michaelis constant of species Macrophage in reaction re124" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re148" id="re125" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa51">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.01285357145825028,0.22387807221481681 0.984063784915842,0.2803797614036374</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00266" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00267" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00123">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re125 </ci>
<ci> kmc_re125_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re125 </ci>
<ci> kmc_re125_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re125_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re125_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re125" id="vmaf_re125" name="Forward maximal velocity of reaction re125" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re125_s103" id="kmc_re125_s103" name="Michaelis constant of species NK cells in reaction re125" value="1" units="substance"/>
<parameter metaid="vmar_re125" id="vmar_re125" name="Revere maximal velocity of reaction re125" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re125_s86" id="kmc_re125_s86" name="Michaelis constant of species T cells in reaction re125" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re149" id="re126" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa64">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa67">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00268" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00269" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00124">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re126 </ci>
<ci> kmc_re126_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re126 </ci>
<ci> kmc_re126_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re126_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re126_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re126" id="vmaf_re126" name="Forward maximal velocity of reaction re126" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re126_s3" id="kmc_re126_s3" name="Michaelis constant of species IL-12 in reaction re126" value="1" units="substance"/>
<parameter metaid="vmar_re126" id="vmar_re126" name="Revere maximal velocity of reaction re126" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re126_s103" id="kmc_re126_s103" name="Michaelis constant of species NK cells in reaction re126" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re150" id="re127" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s101" alias="sa59">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa67">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>3.7738772068252047E-4,-0.03821705528593711</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00270" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00271" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00125">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re127 </ci>
<ci> kmc_re127_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re127 </ci>
<ci> kmc_re127_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re127_s101 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re127_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re127" id="vmaf_re127" name="Forward maximal velocity of reaction re127" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re127_s101" id="kmc_re127_s101" name="Michaelis constant of species IL-18 in reaction re127" value="1" units="substance"/>
<parameter metaid="vmar_re127" id="vmar_re127" name="Revere maximal velocity of reaction re127" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re127_s103" id="kmc_re127_s103" name="Michaelis constant of species NK cells in reaction re127" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re151" id="re128" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s93" alias="sa56">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa67">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00272" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa56</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00273" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00126">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re128 </ci>
<ci> kmc_re128_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re128 </ci>
<ci> kmc_re128_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re128_s93 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re128_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re128" id="vmaf_re128" name="Forward maximal velocity of reaction re128" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re128_s93" id="kmc_re128_s93" name="Michaelis constant of species IL-2 in reaction re128" value="1" units="substance"/>
<parameter metaid="vmar_re128" id="vmar_re128" name="Revere maximal velocity of reaction re128" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re128_s103" id="kmc_re128_s103" name="Michaelis constant of species NK cells in reaction re128" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re152" id="re129" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa67">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa54">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.11143801233379533,0.14605558733175394 0.7403023058966259,-0.33976967225545973</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00274" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00275" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00127">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re129 </ci>
<ci> kmc_re129_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re129 </ci>
<ci> kmc_re129_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re129_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re129_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re129" id="vmaf_re129" name="Forward maximal velocity of reaction re129" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re129_s103" id="kmc_re129_s103" name="Michaelis constant of species NK cells in reaction re129" value="1" units="substance"/>
<parameter metaid="vmar_re129" id="vmar_re129" name="Revere maximal velocity of reaction re129" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re129_s89" id="kmc_re129_s89" name="Michaelis constant of species IFNγ  in reaction re129" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re153" id="re130" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa54">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa52">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.04241955280563947,-0.1182403414655071 0.3855189801800294,-0.5770643393322934</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00276" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00277" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00128">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re130 </ci>
<ci> kmc_re130_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re130 </ci>
<ci> kmc_re130_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re130_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re130_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re130" id="vmaf_re130" name="Forward maximal velocity of reaction re130" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re130_s89" id="kmc_re130_s89" name="Michaelis constant of species IFNγ  in reaction re130" value="1" units="substance"/>
<parameter metaid="vmar_re130" id="vmar_re130" name="Revere maximal velocity of reaction re130" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re130_s87" id="kmc_re130_s87" name="Michaelis constant of species Macrophage in reaction re130" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re154" id="re131" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa67">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa49">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.14788707132746987,0.1579961684883764 0.6805314856683173,-0.34305740237337945</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00278" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00279" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00129">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re131 </ci>
<ci> kmc_re131_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re131 </ci>
<ci> kmc_re131_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re131_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re131_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re131" id="vmaf_re131" name="Forward maximal velocity of reaction re131" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re131_s103" id="kmc_re131_s103" name="Michaelis constant of species NK cells in reaction re131" value="1" units="substance"/>
<parameter metaid="vmar_re131" id="vmar_re131" name="Revere maximal velocity of reaction re131" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re131_s35" id="kmc_re131_s35" name="Michaelis constant of species TNFα in reaction re131" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re155" id="re132" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa49">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa52">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-5.21456660501407E-4,-0.16038208197700765 0.30809864032340406,-0.547391341402947</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00280" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00281" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa52</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00130">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re132 </ci>
<ci> kmc_re132_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re132 </ci>
<ci> kmc_re132_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re132_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re132_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re132" id="vmaf_re132" name="Forward maximal velocity of reaction re132" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re132_s35" id="kmc_re132_s35" name="Michaelis constant of species TNFα in reaction re132" value="1" units="substance"/>
<parameter metaid="vmar_re132" id="vmar_re132" name="Revere maximal velocity of reaction re132" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re132_s87" id="kmc_re132_s87" name="Michaelis constant of species Macrophage in reaction re132" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re156" id="re133" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa54">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa63">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.007135252015000315,-0.13138103892679887 0.13717946365336342,-0.42760969550995354</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00282" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00283" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00131">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re133 </ci>
<ci> kmc_re133_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re133 </ci>
<ci> kmc_re133_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re133_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re133_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re133" id="vmaf_re133" name="Forward maximal velocity of reaction re133" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re133_s89" id="kmc_re133_s89" name="Michaelis constant of species IFNγ  in reaction re133" value="1" units="substance"/>
<parameter metaid="vmar_re133" id="vmar_re133" name="Revere maximal velocity of reaction re133" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re133_s2" id="kmc_re133_s2" name="Michaelis constant of species Dendritic cells in reaction re133" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re157" id="re134" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa54">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa51">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9902103322014648,0.09236864398328981</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00003" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00004" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00132">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re134 </ci>
<ci> kmc_re134_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re134 </ci>
<ci> kmc_re134_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re134_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re134_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re134" id="vmaf_re134" name="Forward maximal velocity of reaction re134" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re134_s89" id="kmc_re134_s89" name="Michaelis constant of species IFNγ  in reaction re134" value="1" units="substance"/>
<parameter metaid="vmar_re134" id="vmar_re134" name="Revere maximal velocity of reaction re134" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re134_s86" id="kmc_re134_s86" name="Michaelis constant of species T cells in reaction re134" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re170" id="re142" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s104" alias="sa77">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00304" species="s104">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa77</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00305" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00137">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re142 </ci>
<ci> kmc_re142_s104 </ci>
</apply>
<ci> s104 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re142 </ci>
<ci> kmc_re142_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s104 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re142_s104 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re142_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re142" id="vmaf_re142" name="Forward maximal velocity of reaction re142" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re142_s104" id="kmc_re142_s104" name="Michaelis constant of species PPRs in reaction re142" value="1" units="substance"/>
<parameter metaid="vmar_re142" id="vmar_re142" name="Revere maximal velocity of reaction re142" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re142_s85" id="kmc_re142_s85" name="Michaelis constant of species NFkB in reaction re142" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re178" id="re143" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa48">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.04824818624288607,0.2068621978148535 0.8898884616783604,0.43674177407999704</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00306" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00307" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00138">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re143 </ci>
<ci> kmc_re143_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re143 </ci>
<ci> kmc_re143_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re143_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re143_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re143" id="vmaf_re143" name="Forward maximal velocity of reaction re143" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re143_s34" id="kmc_re143_s34" name="Michaelis constant of species IL-6 in reaction re143" value="1" units="substance"/>
<parameter metaid="vmar_re143" id="vmar_re143" name="Revere maximal velocity of reaction re143" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re143_s85" id="kmc_re143_s85" name="Michaelis constant of species NFkB in reaction re143" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re76" id="re144" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa48">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s90" alias="sa55">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s89" alias="sa54" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="E"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00308" species="s34">
<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00309" species="s89">
<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00311" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00312" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00313" species="s93">
<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00314" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00139">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> vmaf_re144 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s34 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s89 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s35 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s33 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s3 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s93 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s101 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s94 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> vmar_re144 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s90 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s34 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s89 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s35 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s33 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s3 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s93 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s101 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s94 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s90 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re144" id="vmaf_re144" name="Forward maximal velocity of reaction re144" value="1" units="mole_per_second"/>
<parameter metaid="hco_re144" id="hco_re144" name="Reaction cooperativity" value="1" units="dimensionless"/>
<parameter metaid="kmc_re144_s34" id="kmc_re144_s34" name="Michaelis constant of species IL-6 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s89" id="kmc_re144_s89" name="Michaelis constant of species IFNγ  in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s35" id="kmc_re144_s35" name="Michaelis constant of species TNFα in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s33" id="kmc_re144_s33" name="Michaelis constant of species IL-1β in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s3" id="kmc_re144_s3" name="Michaelis constant of species IL-12 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s93" id="kmc_re144_s93" name="Michaelis constant of species IL-2 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s101" id="kmc_re144_s101" name="Michaelis constant of species IL-18 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s94" id="kmc_re144_s94" name="Michaelis constant of species MCP-1 in reaction re144" value="1" units="substance"/>
<parameter metaid="vmar_re144" id="vmar_re144" name="Revere maximal velocity of reaction re144" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re144_s90" id="kmc_re144_s90" name="Michaelis constant of species Cytokine Storm in reaction re144" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re179" id="re145" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s90" alias="sa55">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s4" alias="sa78">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00317" species="s90">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00318" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa78</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00140">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re145 </ci>
<ci> kmc_re145_s90 </ci>
</apply>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re145 </ci>
<ci> kmc_re145_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re145_s90 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re145_s4 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re145" id="vmaf_re145" name="Forward maximal velocity of reaction re145" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re145_s90" id="kmc_re145_s90" name="Michaelis constant of species Cytokine Storm in reaction re145" value="1" units="substance"/>
<parameter metaid="vmar_re145" id="vmar_re145" name="Revere maximal velocity of reaction re145" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re145_s4" id="kmc_re145_s4" name="Michaelis constant of species Multi-Organ Failure in reaction re145" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re86" id="re146" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s99" alias="sa80">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00319" species="s98">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa79</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00320" species="s99">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa80</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00141">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re146 </ci>
<ci> kmc_re146_s98 </ci>
</apply>
<ci> s98 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re146 </ci>
<ci> kmc_re146_s99 </ci>
</apply>
<ci> s99 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s98 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re146_s98 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re146_s99 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re146" id="vmaf_re146" name="Forward maximal velocity of reaction re146" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re146_s98" id="kmc_re146_s98" name="Michaelis constant of species PI3K in reaction re146" value="1" units="substance"/>
<parameter metaid="vmar_re146" id="vmar_re146" name="Revere maximal velocity of reaction re146" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re146_s99" id="kmc_re146_s99" name="Michaelis constant of species AKT in reaction re146" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re181" id="re147" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s99" alias="sa80">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa62">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00321" species="s99">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa80</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00322" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00142">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re147 </ci>
<ci> kmc_re147_s99 </ci>
</apply>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re147 </ci>
<ci> kmc_re147_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re147_s99 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re147_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re147" id="vmaf_re147" name="Forward maximal velocity of reaction re147" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re147_s99" id="kmc_re147_s99" name="Michaelis constant of species AKT in reaction re147" value="1" units="substance"/>
<parameter metaid="vmar_re147" id="vmar_re147" name="Revere maximal velocity of reaction re147" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re147_s85" id="kmc_re147_s85" name="Michaelis constant of species NFkB in reaction re147" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>