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</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups>
<celldesigner:group id="g1" members="sa1,sa2"/>
</celldesigner:listOfGroups>
<celldesigner:listOfProteins>
<celldesigner:protein id="pr15" name="Insulin Receptor" type="RECEPTOR"/>
<celldesigner:protein id="pr20" name="IL-6" type="GENERIC"/>
<celldesigner:protein id="pr21" name="TNFα" type="GENERIC"/>
<celldesigner:protein id="pr40" name="P38" type="GENERIC"/>
<celldesigner:protein id="pr41" name="PTEN" type="GENERIC"/>
<celldesigner:protein id="pr35" name="IRS-1" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="2.4" id="rs1" name="rs1" side="none"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="pr27" name="AKT" type="GENERIC"/>
<celldesigner:protein id="pr26" name="PI3K" type="GENERIC"/>
<celldesigner:protein id="pr25" name="IRS1" type="GENERIC"/>
<celldesigner:protein id="pr37" name="JNK" type="GENERIC">
<celldesigner:listOfModificationResidues>
<celldesigner:modificationResidue angle="2.4" id="rs1" name="rs1" side="none"/>
</celldesigner:listOfModificationResidues>
</celldesigner:protein>
<celldesigner:protein id="pr2" name="Infection" type="GENERIC"/>
<celldesigner:protein id="pr42" name="iNOS" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes/>
<celldesigner:listOfRNAs/>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
</celldesigner:extension>
</annotation>
<listOfUnitDefinitions>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00058" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00059" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00060" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00061" kind="metre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00062" kind="second"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="mole_per_second" id="mole_per_second" name="mole per second">
<listOfUnits>
<unit metaid="CDMT00088" kind="mole">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00088">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.unit:UO%3A0000013"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</unit>
<unit metaid="CDMT00089" kind="second" exponent="-1">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00089">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.unit:UO%3A0000010"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</unit>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="default" id="default" size="1" units="volume"/>
</listOfCompartments>
<listOfSpecies>
<species metaid="s46" id="s46" name="Insulin" compartment="default" initialAmount="1.53" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>Insulin</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re6"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s47" id="s47" name="Insulin Receptor" compartment="default" initialAmount="1.53" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s34" id="s34" name="IL-6" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re9"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s35" id="s35" name="TNFα" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr21</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s32" id="s32" name="Inflammation" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Inflammation</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re6"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s81" id="s81" name="P38" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr40</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s82" id="s82" name="PTEN" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr41</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re9"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s69" id="s69" name="IRS-1" compartment="default" initialAmount="1.66" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr35</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s12" id="s12" name="IRS-1" compartment="default" initialAmount="1.66" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr35</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="empty"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s37" id="s37" name="Oxidative stress" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Oxidative stress</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s36" id="s36" name="ROS" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ROS</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re9"/>
<celldesigner:catalyzed reaction="re15"/>
<celldesigner:catalyzed reaction="re18"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s74" id="s74" name="Cell death" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Cell death</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s57" id="s57" name="AKT" compartment="default" initialAmount="1.4" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s56" id="s56" name="PI3K" compartment="default" initialAmount="1.36" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s55" id="s55" name="IRS1" compartment="default" initialAmount="1.36" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s75" id="s75" name="Glucose uptake" compartment="default" initialAmount="1.4" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Glucose uptake</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s71" id="s71" name="JNK" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr37</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="empty"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s72" id="s72" name="JNK" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr37</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re8"/>
<celldesigner:catalyzed reaction="re15"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1" id="s1" name="NO" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>ION</celldesigner:class>
<celldesigner:name>NO</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re8"/>
<celldesigner:catalyzed reaction="re9"/>
<celldesigner:catalyzed reaction="re11"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s3" id="s3" name="Infection" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s83" id="s83" name="iNOS" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr42</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re57" id="re2" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s32" alias="sa6">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa3">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00006" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00007" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00092">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re2 </ci>
<ci> kmc_re2_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re2 </ci>
<ci> kmc_re2_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re2" id="vmaf_re2" name="Forward maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s32" id="kmc_re2_s32" name="Michaelis constant of species Inflammation in reaction re2" value="1" units="substance"/>
<parameter metaid="vmar_re2" id="vmar_re2" name="Revere maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s34" id="kmc_re2_s34" name="Michaelis constant of species IL-6 in reaction re2" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re58" id="re3" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s32" alias="sa6">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa5">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00008" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00009" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00093">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re3 </ci>
<ci> kmc_re3_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re3 </ci>
<ci> kmc_re3_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re3" id="vmaf_re3" name="Forward maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s32" id="kmc_re3_s32" name="Michaelis constant of species Inflammation in reaction re3" value="1" units="substance"/>
<parameter metaid="vmar_re3" id="vmar_re3" name="Revere maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s35" id="kmc_re3_s35" name="Michaelis constant of species TNFα in reaction re3" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re59" id="re4" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s32" alias="sa6">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s36" alias="sa14">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<speciesReference metaid="CDMT00010" species="s32">
<annotation>
<celldesigner:extension>
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</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re4 </ci>
<ci> kmc_re4_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re4 </ci>
<ci> kmc_re4_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s36 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re4" id="vmaf_re4" name="Forward maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s32" id="kmc_re4_s32" name="Michaelis constant of species Inflammation in reaction re4" value="1" units="substance"/>
<parameter metaid="vmar_re4" id="vmar_re4" name="Revere maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s36" id="kmc_re4_s36" name="Michaelis constant of species ROS in reaction re4" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re60" id="re5" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s36" alias="sa14">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s37" alias="sa13">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00012" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00013" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00095">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re5 </ci>
<ci> kmc_re5_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re5 </ci>
<ci> kmc_re5_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s37 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re5" id="vmaf_re5" name="Forward maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s36" id="kmc_re5_s36" name="Michaelis constant of species ROS in reaction re5" value="1" units="substance"/>
<parameter metaid="vmar_re5" id="vmar_re5" name="Revere maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s37" id="kmc_re5_s37" name="Michaelis constant of species Oxidative stress in reaction re5" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re83" id="re6" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s46" alias="sa1">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6976480025107836,-0.001769992265386655</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s46" alias="sa9">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s32" aliases="sa6" targetLineIndex="-1,2" editPoints="0.09719327785064857,-0.29520750804734686">
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:linkTarget species="s32" alias="sa6">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00014" species="s47">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00015" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00016" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00017" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00096">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re6 </ci>
<ci> kmc_re6_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re6 </ci>
<ci> kmc_re6_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re6_s32 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s47 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s46 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re6_s32 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re6" id="vmaf_re6" name="Forward maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s47" id="kmc_re6_s47" name="Michaelis constant of species Insulin Receptor in reaction re6" value="1" units="substance"/>
<parameter metaid="vmar_re6" id="vmar_re6" name="Revere maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s46" id="kmc_re6_s46" name="Michaelis constant of species Insulin in reaction re6" value="1" units="substance"/>
<parameter metaid="kic_1_re6_s32" id="kic_1_re6_s32" name="Inhibitory constant for species Inflammationwith 1 binding positions of reaction re6" value="1" units="substance"/>
<parameter metaid="kic_2_re6_s32" id="kic_2_re6_s32" name="Inhibitory constant for species Inflammationwith 2 binding positions of reaction re6" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re84" id="re7" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s47" alias="sa2">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s55" alias="sa18">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00018" species="s47">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00019" species="s55">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00097">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re7 </ci>
<ci> kmc_re7_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re7 </ci>
<ci> kmc_re7_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s47 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s55 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re7" id="vmaf_re7" name="Forward maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s47" id="kmc_re7_s47" name="Michaelis constant of species Insulin Receptor in reaction re7" value="1" units="substance"/>
<parameter metaid="vmar_re7" id="vmar_re7" name="Revere maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s55" id="kmc_re7_s55" name="Michaelis constant of species IRS1 in reaction re7" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re85" id="re8" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s1" alias="sa22">
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<celldesigner:line width="1.0" color="ff000000"/>
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<celldesigner:linkTarget species="s72" alias="sa21">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00020" species="s55">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00021" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00047" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00050" species="s72">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00098">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re8_s1 </ci>
<apply>
<plus/>
<ci> kic_re8_s1 </ci>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re8_s72 </ci>
<apply>
<plus/>
<ci> kic_re8_s72 </ci>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re8 </ci>
<ci> kmc_re8_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re8 </ci>
<ci> kmc_re8_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s55 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s56 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re8" id="vmaf_re8" name="Forward maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s55" id="kmc_re8_s55" name="Michaelis constant of species IRS1 in reaction re8" value="1" units="substance"/>
<parameter metaid="vmar_re8" id="vmar_re8" name="Revere maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s56" id="kmc_re8_s56" name="Michaelis constant of species PI3K in reaction re8" value="1" units="substance"/>
<parameter metaid="kic_re8_s1" id="kic_re8_s1" name="Inhibitory constant for species NO of reaction re8" value="1" units="substance"/>
<parameter metaid="kic_re8_s72" id="kic_re8_s72" name="Inhibitory constant for species JNK of reaction re8" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re86" id="re9" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s56" alias="sa17">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s57" alias="sa16">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s34" aliases="sa3" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s34" alias="sa3">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s82" aliases="sa10" targetLineIndex="-1,5" editPoints="0.49954447275292657,-0.26017394294824037">
<celldesigner:connectScheme connectPolicy="direct">
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<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s82" alias="sa10">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa22" targetLineIndex="-1,4" editPoints="0.695112552577704,-0.14930876259004844">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa22">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s36" aliases="sa14" targetLineIndex="-1,3" editPoints="0.5033588072245416,0.23460685544279114 0.8245800619729073,-0.06407661261298392">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s36" alias="sa14">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00022" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00023" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00024" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00025" species="s82">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00048" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00054" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re9_s34 </ci>
<apply>
<plus/>
<ci> kic_re9_s34 </ci>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<ci> kic_re9_s36 </ci>
</apply>
<apply>
<plus/>
<ci> kic_re9_s36 </ci>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<ci> kic_re9_s82 </ci>
</apply>
<apply>
<plus/>
<ci> kic_re9_s82 </ci>
<apply>
<times/>
<ci> s82 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re9_s1 </ci>
<apply>
<plus/>
<ci> kic_re9_s1 </ci>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re9 </ci>
<ci> kmc_re9_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re9 </ci>
<ci> kmc_re9_s57 </ci>
</apply>
<ci> s57 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s56 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s57 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re9" id="vmaf_re9" name="Forward maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s56" id="kmc_re9_s56" name="Michaelis constant of species PI3K in reaction re9" value="1" units="substance"/>
<parameter metaid="vmar_re9" id="vmar_re9" name="Revere maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s57" id="kmc_re9_s57" name="Michaelis constant of species AKT in reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s34" id="kic_re9_s34" name="Inhibitory constant for species IL-6 of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s82" id="kic_re9_s82" name="Inhibitory constant for species PTEN of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s1" id="kic_re9_s1" name="Inhibitory constant for species NO of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s36" id="kic_re9_s36" name="Inhibitory constant for species ROS of reaction re9" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re68" id="re10" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s12" alias="sa12">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s69" alias="sa11">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00026" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00027" species="s69">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00100">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re10 </ci>
<ci> kmc_re10_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re10 </ci>
<ci> kmc_re10_s69 </ci>
</apply>
<ci> s69 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s12 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s69 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s69 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re10" id="vmaf_re10" name="Forward maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s12" id="kmc_re10_s12" name="Michaelis constant of species IRS-1 in reaction re10" value="1" units="substance"/>
<parameter metaid="vmar_re10" id="vmar_re10" name="Revere maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s69" id="kmc_re10_s69" name="Michaelis constant of species IRS-1 in reaction re10" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re69" id="re11" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s55" alias="sa18">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s12" alias="sa12">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa22" targetLineIndex="-1,7" editPoints="0.9049522297520528,-0.2197930104691901">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa22">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00028" species="s55">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00029" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00049" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00101">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re11 </ci>
<ci> kmc_re11_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re11 </ci>
<ci> kmc_re11_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re11_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s55 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s12 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re11_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re11" id="vmaf_re11" name="Forward maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s55" id="kmc_re11_s55" name="Michaelis constant of species IRS1 in reaction re11" value="1" units="substance"/>
<parameter metaid="vmar_re11" id="vmar_re11" name="Revere maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s12" id="kmc_re11_s12" name="Michaelis constant of species IRS-1 in reaction re11" value="1" units="substance"/>
<parameter metaid="kic_1_re11_s1" id="kic_1_re11_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re11" value="1" units="substance"/>
<parameter metaid="kic_2_re11_s1" id="kic_2_re11_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re11" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re100" id="re12" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa5">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s12" alias="sa12">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4218624202821485,0.49275857520191213</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00030" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00031" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00102">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re12 </ci>
<ci> kmc_re12_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re12 </ci>
<ci> kmc_re12_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s12 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re12" id="vmaf_re12" name="Forward maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s35" id="kmc_re12_s35" name="Michaelis constant of species TNFα in reaction re12" value="1" units="substance"/>
<parameter metaid="vmar_re12" id="vmar_re12" name="Revere maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s12" id="kmc_re12_s12" name="Michaelis constant of species IRS-1 in reaction re12" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re101" id="re13" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa3">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s12" alias="sa12">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.24026408128807847,0.4252809229556971</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00032" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00033" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00103">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re13 </ci>
<ci> kmc_re13_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re13 </ci>
<ci> kmc_re13_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s12 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re13" id="vmaf_re13" name="Forward maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s34" id="kmc_re13_s34" name="Michaelis constant of species IL-6 in reaction re13" value="1" units="substance"/>
<parameter metaid="vmar_re13" id="vmar_re13" name="Revere maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s12" id="kmc_re13_s12" name="Michaelis constant of species IRS-1 in reaction re13" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re102" id="re14" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa13">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s74" alias="sa15">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00034" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00035" species="s74">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00104">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re14 </ci>
<ci> kmc_re14_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re14 </ci>
<ci> kmc_re14_s74 </ci>
</apply>
<ci> s74 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s74 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s74 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re14" id="vmaf_re14" name="Forward maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s37" id="kmc_re14_s37" name="Michaelis constant of species Oxidative stress in reaction re14" value="1" units="substance"/>
<parameter metaid="vmar_re14" id="vmar_re14" name="Revere maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s74" id="kmc_re14_s74" name="Michaelis constant of species Cell death in reaction re14" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re103" id="re15" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s57" alias="sa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s75" alias="sa19">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s36" aliases="sa14" targetLineIndex="-1,4" editPoints="0.5115393327666862,0.30115913378916526">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s36" alias="sa14">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s72" aliases="sa21" targetLineIndex="-1,6" editPoints="0.4957474492325038,0.2913787573912412">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s72" alias="sa21">
<celldesigner:linkAnchor position="N"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00036" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s75">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00038" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
<modifierSpeciesReference metaid="CDMT00053" species="s72">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00105">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re15_s36 </ci>
<apply>
<plus/>
<ci> kic_re15_s36 </ci>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re15_s72 </ci>
<apply>
<plus/>
<ci> kic_re15_s72 </ci>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re15 </ci>
<ci> kmc_re15_s57 </ci>
</apply>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re15 </ci>
<ci> kmc_re15_s75 </ci>
</apply>
<ci> s75 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s57 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s75 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s75 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re15" id="vmaf_re15" name="Forward maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s57" id="kmc_re15_s57" name="Michaelis constant of species AKT in reaction re15" value="1" units="substance"/>
<parameter metaid="vmar_re15" id="vmar_re15" name="Revere maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s75" id="kmc_re15_s75" name="Michaelis constant of species Glucose uptake in reaction re15" value="1" units="substance"/>
<parameter metaid="kic_re15_s36" id="kic_re15_s36" name="Inhibitory constant for species ROS of reaction re15" value="1" units="substance"/>
<parameter metaid="kic_re15_s72" id="kic_re15_s72" name="Inhibitory constant for species JNK of reaction re15" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re108" id="re16" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s81" alias="sa8">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s82" alias="sa10">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00039" species="s81">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00040" species="s82">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00106">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re16 </ci>
<ci> kmc_re16_s81 </ci>
</apply>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re16 </ci>
<ci> kmc_re16_s82 </ci>
</apply>
<ci> s82 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s81 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s82 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s82 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re16" id="vmaf_re16" name="Forward maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s81" id="kmc_re16_s81" name="Michaelis constant of species P38 in reaction re16" value="1" units="substance"/>
<parameter metaid="vmar_re16" id="vmar_re16" name="Revere maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s82" id="kmc_re16_s82" name="Michaelis constant of species PTEN in reaction re16" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re109" id="re17" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s36" alias="sa14">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s81" alias="sa8">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.8856010393046165,0.2066171232720393</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00041" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00042" species="s81">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00107">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re17 </ci>
<ci> kmc_re17_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re17 </ci>
<ci> kmc_re17_s81 </ci>
</apply>
<ci> s81 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s81 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re17" id="vmaf_re17" name="Forward maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s36" id="kmc_re17_s36" name="Michaelis constant of species ROS in reaction re17" value="1" units="substance"/>
<parameter metaid="vmar_re17" id="vmar_re17" name="Revere maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s81" id="kmc_re17_s81" name="Michaelis constant of species P38 in reaction re17" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re99" id="re18" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s71" alias="sa20">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s72" alias="sa21">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s36" aliases="sa14" targetLineIndex="-1,2" editPoints="0.4306424449452485,0.08445723243351244 0.6087312488879134,-0.05509900773930809 0.9632175449651347,0.03038489001154021">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s36" alias="sa14">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00043" species="s71">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00044" species="s72">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00052" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00108">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re18 </ci>
<ci> kmc_re18_s71 </ci>
</apply>
<ci> s71 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re18 </ci>
<ci> kmc_re18_s72 </ci>
</apply>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re18_s36 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s71 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s71 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s72 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re18_s36 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re18" id="vmaf_re18" name="Forward maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s71" id="kmc_re18_s71" name="Michaelis constant of species JNK in reaction re18" value="1" units="substance"/>
<parameter metaid="vmar_re18" id="vmar_re18" name="Revere maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s72" id="kmc_re18_s72" name="Michaelis constant of species JNK in reaction re18" value="1" units="substance"/>
<parameter metaid="kic_1_re18_s36" id="kic_1_re18_s36" name="Inhibitory constant for species ROSwith 1 binding positions of reaction re18" value="1" units="substance"/>
<parameter metaid="kic_2_re18_s36" id="kic_2_re18_s36" name="Inhibitory constant for species ROSwith 2 binding positions of reaction re18" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re19" id="re19" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa5">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s72" alias="sa21">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.008016811565626725,-0.18447088526370115 1.0064752004102668,-0.14789026996149346</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00045" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00046" species="s72">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00109">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re19 </ci>
<ci> kmc_re19_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re19 </ci>
<ci> kmc_re19_s72 </ci>
</apply>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s72 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re19" id="vmaf_re19" name="Forward maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s35" id="kmc_re19_s35" name="Michaelis constant of species TNFα in reaction re19" value="1" units="substance"/>
<parameter metaid="vmar_re19" id="vmar_re19" name="Revere maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s72" id="kmc_re19_s72" name="Michaelis constant of species JNK in reaction re19" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re21" id="re21" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa24">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s32" alias="sa6">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00055" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00056" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00110">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re21 </ci>
<ci> kmc_re21_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re21 </ci>
<ci> kmc_re21_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s32 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re21" id="vmaf_re21" name="Forward maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s3" id="kmc_re21_s3" name="Michaelis constant of species Infection in reaction re21" value="1" units="substance"/>
<parameter metaid="vmar_re21" id="vmar_re21" name="Revere maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s32" id="kmc_re21_s32" name="Michaelis constant of species Inflammation in reaction re21" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re22" id="re22" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa24">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa3">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.8308662976023924,0.37243910924913415</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00051" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00057" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00111">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re22 </ci>
<ci> kmc_re22_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re22 </ci>
<ci> kmc_re22_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re22" id="vmaf_re22" name="Forward maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s3" id="kmc_re22_s3" name="Michaelis constant of species Infection in reaction re22" value="1" units="substance"/>
<parameter metaid="vmar_re22" id="vmar_re22" name="Revere maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s34" id="kmc_re22_s34" name="Michaelis constant of species IL-6 in reaction re22" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re23" id="re23" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa24">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa5">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4331055184702519,0.4953257761636527</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00063" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00064" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00112">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re23 </ci>
<ci> kmc_re23_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re23 </ci>
<ci> kmc_re23_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re23" id="vmaf_re23" name="Forward maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s3" id="kmc_re23_s3" name="Michaelis constant of species Infection in reaction re23" value="1" units="substance"/>
<parameter metaid="vmar_re23" id="vmar_re23" name="Revere maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s35" id="kmc_re23_s35" name="Michaelis constant of species TNFα in reaction re23" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re24" id="re24" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s83" alias="sa25">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa22">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00086" species="s83">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00087" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00113">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re24 </ci>
<ci> kmc_re24_s83 </ci>
</apply>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re24 </ci>
<ci> kmc_re24_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s83 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re24" id="vmaf_re24" name="Forward maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s83" id="kmc_re24_s83" name="Michaelis constant of species iNOS in reaction re24" value="1" units="substance"/>
<parameter metaid="vmar_re24" id="vmar_re24" name="Revere maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s1" id="kmc_re24_s1" name="Michaelis constant of species NO in reaction re24" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re25" id="re25" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa5">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s83" alias="sa25">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.9898668891049223,0.09506094558106692</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00090" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00091" species="s83">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00114">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re25 </ci>
<ci> kmc_re25_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re25 </ci>
<ci> kmc_re25_s83 </ci>
</apply>
<ci> s83 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s83 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re25" id="vmaf_re25" name="Forward maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s35" id="kmc_re25_s35" name="Michaelis constant of species TNFα in reaction re25" value="1" units="substance"/>
<parameter metaid="vmar_re25" id="vmar_re25" name="Revere maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s83" id="kmc_re25_s83" name="Michaelis constant of species iNOS in reaction re25" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>