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<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr57</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s63" id="s63" name="PRRs" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr58</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s64" id="s64" name="IRF-3" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr59</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s65" id="s65" name="IRF-7" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr60</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re1" id="re1" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa2">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa1">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s6" alias="sa6" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="S"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink product="s7" alias="sa7" targetLineIndex="-1,1">
<celldesigner:linkAnchor position="N"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00006" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00016" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00007" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00017" species="s7">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00001">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re1 </ci>
<apply>
<times/>
<ci> kic_re1_s2 </ci>
<ci> kmc_re1_s6 </ci>
</apply>
</apply>
<ci> s2 </ci>
<ci> default </ci>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re1 </ci>
<apply>
<times/>
<ci> kic_re1_s7 </ci>
<ci> kmc_re1_s1 </ci>
</apply>
</apply>
<ci> s1 </ci>
<ci> default </ci>
<ci> s7 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re1_s2 </ci>
<ci> kmc_re1_s6 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kic_re1_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
<ci> s7 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re1_s7 </ci>
<ci> kmc_re1_s1 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kic_re1_s6 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s7 </ci>
<ci> default </ci>
</apply>
<ci> kic_re1_s7 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_re1_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re1" id="vmaf_re1" name="Forward maximal velocity of reaction re1" value="1" units="mole_per_second"/>
<parameter metaid="vmar_re1" id="vmar_re1" name="Revere maximal velocity of reaction re1" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re1_s6" id="kmc_re1_s6" name="Michaelis constant of species L-Arg in reaction re1" value="1" units="substance"/>
<parameter metaid="kmc_re1_s1" id="kmc_re1_s1" name="Michaelis constant of species NO in reaction re1" value="1" units="substance"/>
<parameter metaid="kic_re1_s1" id="kic_re1_s1" name="Inhibitory constant for species NO of reaction re1" value="1" units="substance"/>
<parameter metaid="kic_re1_s7" id="kic_re1_s7" name="Inhibitory constant for species L-Citrulline of reaction re1" value="1" units="substance"/>
<parameter metaid="kic_re1_s2" id="kic_re1_s2" name="Inhibitory constant for species NOS of reaction re1" value="1" units="substance"/>
<parameter metaid="kic_re1_s6" id="kic_re1_s6" name="Inhibitory constant for species L-Arg of reaction re1" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re5" id="re5" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s5" alias="sa5">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00014" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00015" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00002">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re5 </ci>
<ci> kmc_re5_s5 </ci>
</apply>
<ci> s5 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re5 </ci>
<ci> kmc_re5_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s5 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s5 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re5" id="vmaf_re5" name="Forward maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s5" id="kmc_re5_s5" name="Michaelis constant of species Stat-1 in reaction re5" value="1" units="substance"/>
<parameter metaid="vmar_re5" id="vmar_re5" name="Revere maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s2" id="kmc_re5_s2" name="Michaelis constant of species NOS in reaction re5" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re6" id="re6" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s10" alias="sa10">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00003" species="s10">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00004" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00005">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re6 </ci>
<ci> kmc_re6_s10 </ci>
</apply>
<ci> s10 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re6 </ci>
<ci> kmc_re6_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s10 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s10 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re6" id="vmaf_re6" name="Forward maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s10" id="kmc_re6_s10" name="Michaelis constant of species TNFα in reaction re6" value="1" units="substance"/>
<parameter metaid="vmar_re6" id="vmar_re6" name="Revere maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s2" id="kmc_re6_s2" name="Michaelis constant of species NOS in reaction re6" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re7" id="re7" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00008" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00009" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00010">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re7 </ci>
<ci> kmc_re7_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re7 </ci>
<ci> kmc_re7_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re7" id="vmaf_re7" name="Forward maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s9" id="kmc_re7_s9" name="Michaelis constant of species IFNγ in reaction re7" value="1" units="substance"/>
<parameter metaid="vmar_re7" id="vmar_re7" name="Revere maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s2" id="kmc_re7_s2" name="Michaelis constant of species NOS in reaction re7" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re8" id="re8" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s11" alias="sa11">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00011" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00012" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00013">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re8 </ci>
<ci> kmc_re8_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re8 </ci>
<ci> kmc_re8_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s11 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re8" id="vmaf_re8" name="Forward maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s11" id="kmc_re8_s11" name="Michaelis constant of species IL-1β in reaction re8" value="1" units="substance"/>
<parameter metaid="vmar_re8" id="vmar_re8" name="Revere maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s2" id="kmc_re8_s2" name="Michaelis constant of species NOS in reaction re8" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re9" id="re9" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s12" alias="sa12">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00018" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00019" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00020">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re9 </ci>
<ci> kmc_re9_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re9 </ci>
<ci> kmc_re9_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s12 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re9" id="vmaf_re9" name="Forward maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s12" id="kmc_re9_s12" name="Michaelis constant of species IL-10 in reaction re9" value="1" units="substance"/>
<parameter metaid="vmar_re9" id="vmar_re9" name="Revere maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s2" id="kmc_re9_s2" name="Michaelis constant of species NOS in reaction re9" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re10" id="re10" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00021" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00022" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00023">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re10 </ci>
<ci> kmc_re10_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re10 </ci>
<ci> kmc_re10_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re10" id="vmaf_re10" name="Forward maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s13" id="kmc_re10_s13" name="Michaelis constant of species IL-12 in reaction re10" value="1" units="substance"/>
<parameter metaid="vmar_re10" id="vmar_re10" name="Revere maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s2" id="kmc_re10_s2" name="Michaelis constant of species NOS in reaction re10" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re11" id="re11" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s14" alias="sa14">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00024" species="s14">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00025" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00026">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re11 </ci>
<ci> kmc_re11_s14 </ci>
</apply>
<ci> s14 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re11 </ci>
<ci> kmc_re11_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s14 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s14 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re11" id="vmaf_re11" name="Forward maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s14" id="kmc_re11_s14" name="Michaelis constant of species MIF in reaction re11" value="1" units="substance"/>
<parameter metaid="vmar_re11" id="vmar_re11" name="Revere maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s2" id="kmc_re11_s2" name="Michaelis constant of species NOS in reaction re11" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re12" id="re12" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s8" alias="sa8">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00028" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00029" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00027">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re12 </ci>
<ci> kmc_re12_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re12 </ci>
<ci> kmc_re12_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s8 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re12" id="vmaf_re12" name="Forward maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s8" id="kmc_re12_s8" name="Michaelis constant of species NFKB in reaction re12" value="1" units="substance"/>
<parameter metaid="vmar_re12" id="vmar_re12" name="Revere maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s2" id="kmc_re12_s2" name="Michaelis constant of species NOS in reaction re12" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re13" id="re13" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s16" alias="sa16">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s15" alias="sa15">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00030" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00031" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00032">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re13 </ci>
<ci> kmc_re13_s16 </ci>
</apply>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re13 </ci>
<ci> kmc_re13_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s16 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s15 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re13" id="vmaf_re13" name="Forward maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s16" id="kmc_re13_s16" name="Michaelis constant of species PKR in reaction re13" value="1" units="substance"/>
<parameter metaid="vmar_re13" id="vmar_re13" name="Revere maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s15" id="kmc_re13_s15" name="Michaelis constant of species IRF-1 in reaction re13" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re14" id="re14" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s16" alias="sa16">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s8" alias="sa8">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00033" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00034" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00035">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re14 </ci>
<ci> kmc_re14_s16 </ci>
</apply>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re14 </ci>
<ci> kmc_re14_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s16 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s8 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re14" id="vmaf_re14" name="Forward maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s16" id="kmc_re14_s16" name="Michaelis constant of species PKR in reaction re14" value="1" units="substance"/>
<parameter metaid="vmar_re14" id="vmar_re14" name="Revere maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s8" id="kmc_re14_s8" name="Michaelis constant of species NFKB in reaction re14" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re15" id="re15" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s17" alias="sa17"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00036" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00038">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re15 </ci>
<ci> kmc_re15_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re15 </ci>
<ci> kmc_re15_s17 </ci>
</apply>
<ci> s17 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s17 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s17 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re15" id="vmaf_re15" name="Forward maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s1" id="kmc_re15_s1" name="Michaelis constant of species NO in reaction re15" value="1" units="substance"/>
<parameter metaid="vmar_re15" id="vmar_re15" name="Revere maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s17" id="kmc_re15_s17" name="Michaelis constant of species NO2- in reaction re15" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re16" id="re16" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s20" alias="sa20">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s21" alias="sa21">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.11190751140264865,-0.32006568640504085</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa1" targetLineIndex="-1,2" editPoints="0.3947924900766222,0.1860648879512601">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00039" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00040" species="s21">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00068" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00041">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re16 </ci>
<ci> kmc_re16_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re16 </ci>
<ci> kmc_re16_s21 </ci>
</apply>
<ci> s21 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re16_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s20 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s21 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s21 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re16_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re16" id="vmaf_re16" name="Forward maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s20" id="kmc_re16_s20" name="Michaelis constant of species Dendritic cells in reaction re16" value="1" units="substance"/>
<parameter metaid="vmar_re16" id="vmar_re16" name="Revere maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s21" id="kmc_re16_s21" name="Michaelis constant of species IL-2 in reaction re16" value="1" units="substance"/>
<parameter metaid="kic_1_re16_s1" id="kic_1_re16_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re16" value="1" units="substance"/>
<parameter metaid="kic_2_re16_s1" id="kic_2_re16_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re16" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re17" id="re17" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s19" alias="sa19">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s21" alias="sa21">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.14793244030285813,-0.3442050087361679</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa1" targetLineIndex="-1,2" editPoints="0.4639223526134497,0.22836079287696853">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00042" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00043" species="s21">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00069" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00044">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re17 </ci>
<ci> kmc_re17_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re17 </ci>
<ci> kmc_re17_s21 </ci>
</apply>
<ci> s21 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re17_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s19 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s21 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s21 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re17_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re17" id="vmaf_re17" name="Forward maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s19" id="kmc_re17_s19" name="Michaelis constant of species Macrophages in reaction re17" value="1" units="substance"/>
<parameter metaid="vmar_re17" id="vmar_re17" name="Revere maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s21" id="kmc_re17_s21" name="Michaelis constant of species IL-2 in reaction re17" value="1" units="substance"/>
<parameter metaid="kic_1_re17_s1" id="kic_1_re17_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re17" value="1" units="substance"/>
<parameter metaid="kic_2_re17_s1" id="kic_2_re17_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re17" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re18" id="re18" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s25" alias="sa25">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00045" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00046" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00047">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re18 </ci>
<ci> kmc_re18_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re18 </ci>
<ci> kmc_re18_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s25 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re18" id="vmaf_re18" name="Forward maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s1" id="kmc_re18_s1" name="Michaelis constant of species NO in reaction re18" value="1" units="substance"/>
<parameter metaid="vmar_re18" id="vmar_re18" name="Revere maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s25" id="kmc_re18_s25" name="Michaelis constant of species Bcl-2 in reaction re18" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re19" id="re19" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s62" alias="sa71">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s61" alias="sa70">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00048" species="s62">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa71</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00049" species="s61">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa70</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00050">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re19 </ci>
<ci> kmc_re19_s62 </ci>
</apply>
<ci> s62 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re19 </ci>
<ci> kmc_re19_s61 </ci>
</apply>
<ci> s61 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s62 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s62 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s61 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s61 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re19" id="vmaf_re19" name="Forward maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s62" id="kmc_re19_s62" name="Michaelis constant of species T cell in reaction re19" value="1" units="substance"/>
<parameter metaid="vmar_re19" id="vmar_re19" name="Revere maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s61" id="kmc_re19_s61" name="Michaelis constant of species Apoptosis in reaction re19" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re20" id="re20" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s30" alias="sa30">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00051" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00052" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa30</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00053">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re20 </ci>
<ci> kmc_re20_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re20 </ci>
<ci> kmc_re20_s30 </ci>
</apply>
<ci> s30 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re20_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s30 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re20_s30 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re20" id="vmaf_re20" name="Forward maximal velocity of reaction re20" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re20_s29" id="kmc_re20_s29" name="Michaelis constant of species T-Cell in reaction re20" value="1" units="substance"/>
<parameter metaid="vmar_re20" id="vmar_re20" name="Revere maximal velocity of reaction re20" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re20_s30" id="kmc_re20_s30" name="Michaelis constant of species T-cell accumulation in reaction re20" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re22" id="re22" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s32" alias="sa32">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s29" alias="sa29">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa1" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00054" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00055" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00056" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00057">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re22 </ci>
<ci> kmc_re22_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re22 </ci>
<ci> kmc_re22_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re22_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s29 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re22_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re22" id="vmaf_re22" name="Forward maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s32" id="kmc_re22_s32" name="Michaelis constant of species P-selectin in reaction re22" value="1" units="substance"/>
<parameter metaid="vmar_re22" id="vmar_re22" name="Revere maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s29" id="kmc_re22_s29" name="Michaelis constant of species T-Cell in reaction re22" value="1" units="substance"/>
<parameter metaid="kic_1_re22_s1" id="kic_1_re22_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re22" value="1" units="substance"/>
<parameter metaid="kic_2_re22_s1" id="kic_2_re22_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re22" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re23" id="re23" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa34">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa35">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa1" targetLineIndex="-1,6">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00058" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa34</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00059" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa35</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00060" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00061">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re23 </ci>
<ci> kmc_re23_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re23 </ci>
<ci> kmc_re23_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re23_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s35 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re23_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re23" id="vmaf_re23" name="Forward maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s34" id="kmc_re23_s34" name="Michaelis constant of species Lymphocytes in reaction re23" value="1" units="substance"/>
<parameter metaid="vmar_re23" id="vmar_re23" name="Revere maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s35" id="kmc_re23_s35" name="Michaelis constant of species Lymphocyte proliferation in reaction re23" value="1" units="substance"/>
<parameter metaid="kic_1_re23_s1" id="kic_1_re23_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re23" value="1" units="substance"/>
<parameter metaid="kic_2_re23_s1" id="kic_2_re23_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re23" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re24" id="re24" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s19" alias="sa19">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
<celldesigner:lineDirection index="5" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>2.7291221951930567E-4,-0.09351653163242224 0.11949355889576241,-0.120644449910014 0.29837843881437687,-0.16194953144277724 0.9437025932029874,-0.3154684640065737 1.0168017523970094,-0.005587765216948926</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfLineDirection>
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<celldesigner:linkTarget species="s1" alias="sa1">
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00062" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00063" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00064" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00065">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re24 </ci>
<ci> kmc_re24_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re24 </ci>
<ci> kmc_re24_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re24_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s19 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s13 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re24_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re24" id="vmaf_re24" name="Forward maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s19" id="kmc_re24_s19" name="Michaelis constant of species Macrophages in reaction re24" value="1" units="substance"/>
<parameter metaid="vmar_re24" id="vmar_re24" name="Revere maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s13" id="kmc_re24_s13" name="Michaelis constant of species IL-12 in reaction re24" value="1" units="substance"/>
<parameter metaid="kic_1_re24_s1" id="kic_1_re24_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re24" value="1" units="substance"/>
<parameter metaid="kic_2_re24_s1" id="kic_2_re24_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re24" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re25" id="re25" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s29" alias="sa29">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00066" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00067" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00070">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re25 </ci>
<ci> kmc_re25_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re25 </ci>
<ci> kmc_re25_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s29 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re25" id="vmaf_re25" name="Forward maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s13" id="kmc_re25_s13" name="Michaelis constant of species IL-12 in reaction re25" value="1" units="substance"/>
<parameter metaid="vmar_re25" id="vmar_re25" name="Revere maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s29" id="kmc_re25_s29" name="Michaelis constant of species T-Cell in reaction re25" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re26" id="re26" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s19" alias="sa19">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s10" alias="sa10">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
<celldesigner:lineDirection index="5" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="UNKNOWN_CATALYSIS" modifiers="s1" aliases="sa1" targetLineIndex="-1,5">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00071" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00072" species="s10">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00073" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00074">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re26 </ci>
<ci> kmc_re26_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re26 </ci>
<ci> kmc_re26_s10 </ci>
</apply>
<ci> s10 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re26_s19 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s10 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re26_s10 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re26" id="vmaf_re26" name="Forward maximal velocity of reaction re26" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re26_s19" id="kmc_re26_s19" name="Michaelis constant of species Macrophages in reaction re26" value="1" units="substance"/>
<parameter metaid="vmar_re26" id="vmar_re26" name="Revere maximal velocity of reaction re26" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re26_s10" id="kmc_re26_s10" name="Michaelis constant of species TNFα in reaction re26" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re27" id="re27" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s36" alias="sa38">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s8" alias="sa8"/>
</celldesigner:baseProducts>
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00075" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00076" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00077">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re27 </ci>
<ci> kmc_re27_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re27 </ci>
<ci> kmc_re27_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re27_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re27_s8 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re27" id="vmaf_re27" name="Forward maximal velocity of reaction re27" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re27_s36" id="kmc_re27_s36" name="Michaelis constant of species IkB in reaction re27" value="1" units="substance"/>
<parameter metaid="vmar_re27" id="vmar_re27" name="Revere maximal velocity of reaction re27" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re27_s8" id="kmc_re27_s8" name="Michaelis constant of species NFKB in reaction re27" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re28" id="re28" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s36" alias="sa38">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7004118344020166,-0.334362649238531</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00078" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00079" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00080">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re28 </ci>
<ci> kmc_re28_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re28 </ci>
<ci> kmc_re28_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re28_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re28_s36 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re28" id="vmaf_re28" name="Forward maximal velocity of reaction re28" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re28_s1" id="kmc_re28_s1" name="Michaelis constant of species NO in reaction re28" value="1" units="substance"/>
<parameter metaid="vmar_re28" id="vmar_re28" name="Revere maximal velocity of reaction re28" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re28_s36" id="kmc_re28_s36" name="Michaelis constant of species IkB in reaction re28" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re29" id="re29" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s8" alias="sa8">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s10" alias="sa10">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00081" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00082" species="s10">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00083">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re29 </ci>
<ci> kmc_re29_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re29 </ci>
<ci> kmc_re29_s10 </ci>
</apply>
<ci> s10 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re29_s8 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s10 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re29_s10 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re29" id="vmaf_re29" name="Forward maximal velocity of reaction re29" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re29_s8" id="kmc_re29_s8" name="Michaelis constant of species NFKB in reaction re29" value="1" units="substance"/>
<parameter metaid="vmar_re29" id="vmar_re29" name="Revere maximal velocity of reaction re29" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re29_s10" id="kmc_re29_s10" name="Michaelis constant of species TNFα in reaction re29" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re30" id="re30" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s21" alias="sa21">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00084" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00085" species="s21">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00086">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re30 </ci>
<ci> kmc_re30_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re30 </ci>
<ci> kmc_re30_s21 </ci>
</apply>
<ci> s21 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re30_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s21 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re30_s21 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re30" id="vmaf_re30" name="Forward maximal velocity of reaction re30" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re30_s29" id="kmc_re30_s29" name="Michaelis constant of species T-Cell in reaction re30" value="1" units="substance"/>
<parameter metaid="vmar_re30" id="vmar_re30" name="Revere maximal velocity of reaction re30" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re30_s21" id="kmc_re30_s21" name="Michaelis constant of species IL-2 in reaction re30" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re31" id="re31" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.020135003474602176,-0.03828080310371895 0.24491293801816316,0.034178992752853965 0.9414191203128053,0.2606916790058513 1.0236710791273265,0.007218829834324314</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s1" aliases="sa1" targetLineIndex="-1,2">
<celldesigner:connectScheme connectPolicy="direct">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa1">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00087" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00088" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00089" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00090">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re31 </ci>
<ci> kmc_re31_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re31 </ci>
<ci> kmc_re31_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re31_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s9 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re31_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re31" id="vmaf_re31" name="Forward maximal velocity of reaction re31" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re31_s29" id="kmc_re31_s29" name="Michaelis constant of species T-Cell in reaction re31" value="1" units="substance"/>
<parameter metaid="vmar_re31" id="vmar_re31" name="Revere maximal velocity of reaction re31" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re31_s9" id="kmc_re31_s9" name="Michaelis constant of species IFNγ in reaction re31" value="1" units="substance"/>
<parameter metaid="kic_1_re31_s1" id="kic_1_re31_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re31" value="1" units="substance"/>
<parameter metaid="kic_2_re31_s1" id="kic_2_re31_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re31" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re32" id="re32" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s37" alias="sa40">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00091" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00092" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00093">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re32 </ci>
<ci> kmc_re32_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re32 </ci>
<ci> kmc_re32_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re32_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re32_s37 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re32" id="vmaf_re32" name="Forward maximal velocity of reaction re32" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re32_s1" id="kmc_re32_s1" name="Michaelis constant of species NO in reaction re32" value="1" units="substance"/>
<parameter metaid="vmar_re32" id="vmar_re32" name="Revere maximal velocity of reaction re32" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re32_s37" id="kmc_re32_s37" name="Michaelis constant of species IL-4 in reaction re32" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re33" id="re33" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa40">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s29" alias="sa29">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2427839886983424,0.836776554946955 1.1649366335528915,0.5711877152782945</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00094" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00095" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00096">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re33 </ci>
<ci> kmc_re33_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re33 </ci>
<ci> kmc_re33_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re33_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re33_s29 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re33" id="vmaf_re33" name="Forward maximal velocity of reaction re33" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re33_s37" id="kmc_re33_s37" name="Michaelis constant of species IL-4 in reaction re33" value="1" units="substance"/>
<parameter metaid="vmar_re33" id="vmar_re33" name="Revere maximal velocity of reaction re33" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re33_s29" id="kmc_re33_s29" name="Michaelis constant of species T-Cell in reaction re33" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re34" id="re34" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s37" alias="sa40">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00097" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00098" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re34 </ci>
<ci> kmc_re34_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re34 </ci>
<ci> kmc_re34_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re34_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re34_s37 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re34" id="vmaf_re34" name="Forward maximal velocity of reaction re34" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re34_s29" id="kmc_re34_s29" name="Michaelis constant of species T-Cell in reaction re34" value="1" units="substance"/>
<parameter metaid="vmar_re34" id="vmar_re34" name="Revere maximal velocity of reaction re34" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re34_s37" id="kmc_re34_s37" name="Michaelis constant of species IL-4 in reaction re34" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re35" id="re35" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s19" alias="sa19">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="5">
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<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
<celldesigner:lineDirection index="5" value="unknown"/>
<celldesigner:lineDirection index="6" value="unknown"/>
</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00100" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00101" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00102">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re35 </ci>
<ci> kmc_re35_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re35 </ci>
<ci> kmc_re35_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re35_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re35_s19 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re35" id="vmaf_re35" name="Forward maximal velocity of reaction re35" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re35_s9" id="kmc_re35_s9" name="Michaelis constant of species IFNγ in reaction re35" value="1" units="substance"/>
<parameter metaid="vmar_re35" id="vmar_re35" name="Revere maximal velocity of reaction re35" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re35_s19" id="kmc_re35_s19" name="Michaelis constant of species Macrophages in reaction re35" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re36" id="re36" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa40">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s38" alias="sa41">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00103" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00104" species="s38">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00105">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re36 </ci>
<ci> kmc_re36_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re36 </ci>
<ci> kmc_re36_s38 </ci>
</apply>
<ci> s38 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re36_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s38 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re36_s38 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re36" id="vmaf_re36" name="Forward maximal velocity of reaction re36" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re36_s37" id="kmc_re36_s37" name="Michaelis constant of species IL-4 in reaction re36" value="1" units="substance"/>
<parameter metaid="vmar_re36" id="vmar_re36" name="Revere maximal velocity of reaction re36" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re36_s38" id="kmc_re36_s38" name="Michaelis constant of species VCAM-1 in reaction re36" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re37" id="re37" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s19" alias="sa19">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa1">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5567901369267085,-0.23521822094864175</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00106" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00107" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00108">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re37 </ci>
<ci> kmc_re37_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re37 </ci>
<ci> kmc_re37_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re37_s19 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re37_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re37" id="vmaf_re37" name="Forward maximal velocity of reaction re37" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re37_s19" id="kmc_re37_s19" name="Michaelis constant of species Macrophages in reaction re37" value="1" units="substance"/>
<parameter metaid="vmar_re37" id="vmar_re37" name="Revere maximal velocity of reaction re37" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re37_s1" id="kmc_re37_s1" name="Michaelis constant of species NO in reaction re37" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re38" id="re38" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s19" alias="sa19">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="3">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.01765067968133538,-0.10049797368328928 0.9136415783628831,-0.37576499576926825 1.0240232352616885,-0.00728129310731207</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00109" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00110" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00111">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re38 </ci>
<ci> kmc_re38_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re38 </ci>
<ci> kmc_re38_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re38_s19 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re38_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re38" id="vmaf_re38" name="Forward maximal velocity of reaction re38" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re38_s19" id="kmc_re38_s19" name="Michaelis constant of species Macrophages in reaction re38" value="1" units="substance"/>
<parameter metaid="vmar_re38" id="vmar_re38" name="Revere maximal velocity of reaction re38" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re38_s11" id="kmc_re38_s11" name="Michaelis constant of species IL-1β in reaction re38" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re39" id="re39" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s39" alias="sa43">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa2">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00112" species="s39">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00113" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00114">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re39 </ci>
<ci> kmc_re39_s39 </ci>
</apply>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re39 </ci>
<ci> kmc_re39_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re39_s39 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re39_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re39" id="vmaf_re39" name="Forward maximal velocity of reaction re39" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re39_s39" id="kmc_re39_s39" name="Michaelis constant of species Viral infection in reaction re39" value="1" units="substance"/>
<parameter metaid="vmar_re39" id="vmar_re39" name="Revere maximal velocity of reaction re39" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re39_s2" id="kmc_re39_s2" name="Michaelis constant of species NOS in reaction re39" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re40" id="re40" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s40" alias="sa44">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.11058131464758685,-0.42687963383488414 0.8264971296811373,-0.6717940500230739</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00115" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00116" species="s40">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00117">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re40 </ci>
<ci> kmc_re40_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re40 </ci>
<ci> kmc_re40_s40 </ci>
</apply>
<ci> s40 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re40_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re40_s40 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re40" id="vmaf_re40" name="Forward maximal velocity of reaction re40" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re40_s29" id="kmc_re40_s29" name="Michaelis constant of species T-Cell in reaction re40" value="1" units="substance"/>
<parameter metaid="vmar_re40" id="vmar_re40" name="Revere maximal velocity of reaction re40" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re40_s40" id="kmc_re40_s40" name="Michaelis constant of species IL-5 in reaction re40" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re41" id="re41" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s41" alias="sa45">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.10895532438826311,-0.4546846569730665 0.8360362819279727,-0.6810775488788612</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00118" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00119" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00120">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re41 </ci>
<ci> kmc_re41_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re41 </ci>
<ci> kmc_re41_s41 </ci>
</apply>
<ci> s41 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re41_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re41_s41 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re41" id="vmaf_re41" name="Forward maximal velocity of reaction re41" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re41_s29" id="kmc_re41_s29" name="Michaelis constant of species T-Cell in reaction re41" value="1" units="substance"/>
<parameter metaid="vmar_re41" id="vmar_re41" name="Revere maximal velocity of reaction re41" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re41_s41" id="kmc_re41_s41" name="Michaelis constant of species IL-6 in reaction re41" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re42" id="re42" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s42" alias="sa46">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.08150989184400828,-0.3639320826200141 0.8649982297740944,-0.5819310563684867</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00121" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00122" species="s42">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa46</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00123">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re42 </ci>
<ci> kmc_re42_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re42 </ci>
<ci> kmc_re42_s42 </ci>
</apply>
<ci> s42 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re42_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re42_s42 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re42" id="vmaf_re42" name="Forward maximal velocity of reaction re42" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re42_s29" id="kmc_re42_s29" name="Michaelis constant of species T-Cell in reaction re42" value="1" units="substance"/>
<parameter metaid="vmar_re42" id="vmar_re42" name="Revere maximal velocity of reaction re42" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re42_s42" id="kmc_re42_s42" name="Michaelis constant of species IL-13 in reaction re42" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re45" id="re45" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa40">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s23" alias="sa23">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.05773630714040401,0.10122443063431463 0.41500646231529803,0.35136885591206557 0.7264484456860756,0.516478037182438</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00124" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00125" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00126">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re45 </ci>
<ci> kmc_re45_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re45 </ci>
<ci> kmc_re45_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re45_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re45_s23 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re45" id="vmaf_re45" name="Forward maximal velocity of reaction re45" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re45_s37" id="kmc_re45_s37" name="Michaelis constant of species IL-4 in reaction re45" value="1" units="substance"/>
<parameter metaid="vmar_re45" id="vmar_re45" name="Revere maximal velocity of reaction re45" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re45_s23" id="kmc_re45_s23" name="Michaelis constant of species Mast cells in reaction re45" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re46" id="re46" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa40">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s43" alias="sa47">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.05978282329714357,0.13462865106555477 0.3744578019635334,0.32407348573574946 0.7834554438265906,0.500206053737265</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00127" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00128" species="s43">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00129">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re46 </ci>
<ci> kmc_re46_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re46 </ci>
<ci> kmc_re46_s43 </ci>
</apply>
<ci> s43 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re46_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re46_s43 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re46" id="vmaf_re46" name="Forward maximal velocity of reaction re46" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re46_s37" id="kmc_re46_s37" name="Michaelis constant of species IL-4 in reaction re46" value="1" units="substance"/>
<parameter metaid="vmar_re46" id="vmar_re46" name="Revere maximal velocity of reaction re46" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re46_s43" id="kmc_re46_s43" name="Michaelis constant of species Eosinophils in reaction re46" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re47" id="re47" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s40" alias="sa44">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s23" alias="sa23">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.03747836757811385,0.0677259998112083 0.7217645763191847,0.4966520877253706</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00130" species="s40">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00131" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00132">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re47 </ci>
<ci> kmc_re47_s40 </ci>
</apply>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re47 </ci>
<ci> kmc_re47_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re47_s40 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re47_s23 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re47" id="vmaf_re47" name="Forward maximal velocity of reaction re47" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re47_s40" id="kmc_re47_s40" name="Michaelis constant of species IL-5 in reaction re47" value="1" units="substance"/>
<parameter metaid="vmar_re47" id="vmar_re47" name="Revere maximal velocity of reaction re47" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re47_s23" id="kmc_re47_s23" name="Michaelis constant of species Mast cells in reaction re47" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re48" id="re48" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s40" alias="sa44">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s43" alias="sa47">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.03725645374034059,0.08155266628980562 0.7890711904022893,0.45980595505656985</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00133" species="s40">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00134" species="s43">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00135">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re48 </ci>
<ci> kmc_re48_s40 </ci>
</apply>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re48 </ci>
<ci> kmc_re48_s43 </ci>
</apply>
<ci> s43 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re48_s40 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re48_s43 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re48" id="vmaf_re48" name="Forward maximal velocity of reaction re48" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re48_s40" id="kmc_re48_s40" name="Michaelis constant of species IL-5 in reaction re48" value="1" units="substance"/>
<parameter metaid="vmar_re48" id="vmar_re48" name="Revere maximal velocity of reaction re48" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re48_s43" id="kmc_re48_s43" name="Michaelis constant of species Eosinophils in reaction re48" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re49" id="re49" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s41" alias="sa45">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s23" alias="sa23">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.039029371645817434,0.058381728418383405 0.6912088941407175,0.5053138599879023</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00136" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00137" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00138">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re49 </ci>
<ci> kmc_re49_s41 </ci>
</apply>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re49 </ci>
<ci> kmc_re49_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re49_s41 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re49_s23 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re49" id="vmaf_re49" name="Forward maximal velocity of reaction re49" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re49_s41" id="kmc_re49_s41" name="Michaelis constant of species IL-6 in reaction re49" value="1" units="substance"/>
<parameter metaid="vmar_re49" id="vmar_re49" name="Revere maximal velocity of reaction re49" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re49_s23" id="kmc_re49_s23" name="Michaelis constant of species Mast cells in reaction re49" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re50" id="re50" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s41" alias="sa45">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s43" alias="sa47">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.020829931555636172,0.03769538087907165 0.7855557369837003,0.4344573401033731</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00139" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00140" species="s43">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa47</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00141">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re50 </ci>
<ci> kmc_re50_s41 </ci>
</apply>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re50 </ci>
<ci> kmc_re50_s43 </ci>
</apply>
<ci> s43 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re50_s41 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re50_s43 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re50" id="vmaf_re50" name="Forward maximal velocity of reaction re50" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re50_s41" id="kmc_re50_s41" name="Michaelis constant of species IL-6 in reaction re50" value="1" units="substance"/>
<parameter metaid="vmar_re50" id="vmar_re50" name="Revere maximal velocity of reaction re50" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re50_s43" id="kmc_re50_s43" name="Michaelis constant of species Eosinophils in reaction re50" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re51" id="re51" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s42" alias="sa46">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s23" alias="sa23">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re51 </ci>
<ci> kmc_re51_s42 </ci>
</apply>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re51 </ci>
<ci> kmc_re51_s23 </ci>
</apply>
<ci> s23 </ci>
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</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
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</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re51_s23 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re51" id="vmaf_re51" name="Forward maximal velocity of reaction re51" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re51_s42" id="kmc_re51_s42" name="Michaelis constant of species IL-13 in reaction re51" value="1" units="substance"/>
<parameter metaid="vmar_re51" id="vmar_re51" name="Revere maximal velocity of reaction re51" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re51_s23" id="kmc_re51_s23" name="Michaelis constant of species Mast cells in reaction re51" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
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</annotation>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re52 </ci>
<ci> kmc_re52_s42 </ci>
</apply>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
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<ci> kmc_re52_s43 </ci>
</apply>
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<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s42 </ci>
<ci> default </ci>
</apply>
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</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s43 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re52" id="vmaf_re52" name="Forward maximal velocity of reaction re52" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re52_s42" id="kmc_re52_s42" name="Michaelis constant of species IL-13 in reaction re52" value="1" units="substance"/>
<parameter metaid="vmar_re52" id="vmar_re52" name="Revere maximal velocity of reaction re52" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re52_s43" id="kmc_re52_s43" name="Michaelis constant of species Eosinophils in reaction re52" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
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<kineticLaw metaid="CDMT00150">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re53 </ci>
<ci> kmc_re53_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re53 </ci>
<ci> kmc_re53_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
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<divide/>
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<times/>
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</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re53_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re53" id="vmaf_re53" name="Forward maximal velocity of reaction re53" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re53_s20" id="kmc_re53_s20" name="Michaelis constant of species Dendritic cells in reaction re53" value="1" units="substance"/>
<parameter metaid="vmar_re53" id="vmar_re53" name="Revere maximal velocity of reaction re53" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re53_s13" id="kmc_re53_s13" name="Michaelis constant of species IL-12 in reaction re53" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
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<divide/>
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<minus/>
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<times/>
<apply>
<divide/>
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<ci> kmc_re54_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
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<ci> kmc_re54_s10 </ci>
</apply>
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<divide/>
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<times/>
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</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s10 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re54_s10 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re54" id="vmaf_re54" name="Forward maximal velocity of reaction re54" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re54_s20" id="kmc_re54_s20" name="Michaelis constant of species Dendritic cells in reaction re54" value="1" units="substance"/>
<parameter metaid="vmar_re54" id="vmar_re54" name="Revere maximal velocity of reaction re54" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re54_s10" id="kmc_re54_s10" name="Michaelis constant of species TNFα in reaction re54" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
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<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re55 </ci>
<ci> kmc_re55_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
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<ci> kmc_re55_s41 </ci>
</apply>
<ci> s41 </ci>
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</apply>
<apply>
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<divide/>
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<times/>
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</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re55_s41 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
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<parameter metaid="kmc_re55_s20" id="kmc_re55_s20" name="Michaelis constant of species Dendritic cells in reaction re55" value="1" units="substance"/>
<parameter metaid="vmar_re55" id="vmar_re55" name="Revere maximal velocity of reaction re55" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re55_s41" id="kmc_re55_s41" name="Michaelis constant of species IL-6 in reaction re55" value="1" units="substance"/>
</listOfParameters>
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<divide/>
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<minus/>
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<times/>
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<divide/>
<ci> vmaf_re56 </ci>
<ci> kmc_re56_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re56 </ci>
<ci> kmc_re56_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re56_s20 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re56_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
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<parameter metaid="kmc_re56_s20" id="kmc_re56_s20" name="Michaelis constant of species Dendritic cells in reaction re56" value="1" units="substance"/>
<parameter metaid="vmar_re56" id="vmar_re56" name="Revere maximal velocity of reaction re56" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re56_s9" id="kmc_re56_s9" name="Michaelis constant of species IFNγ in reaction re56" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</annotation>
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<kineticLaw metaid="CDMT00162">
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re57 </ci>
<ci> kmc_re57_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re57 </ci>
<ci> kmc_re57_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re57_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re57_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re57" id="vmaf_re57" name="Forward maximal velocity of reaction re57" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re57_s34" id="kmc_re57_s34" name="Michaelis constant of species Lymphocytes in reaction re57" value="1" units="substance"/>
<parameter metaid="vmar_re57" id="vmar_re57" name="Revere maximal velocity of reaction re57" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re57_s9" id="kmc_re57_s9" name="Michaelis constant of species IFNγ in reaction re57" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re58" id="re58" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s5" alias="sa5">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.08365688680669825,0.06574984451398613 0.3049362836984746,0.552368451784587</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00163" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00164" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00165">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re58 </ci>
<ci> kmc_re58_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re58 </ci>
<ci> kmc_re58_s5 </ci>
</apply>
<ci> s5 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re58_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s5 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re58_s5 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re58" id="vmaf_re58" name="Forward maximal velocity of reaction re58" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re58_s9" id="kmc_re58_s9" name="Michaelis constant of species IFNγ in reaction re58" value="1" units="substance"/>
<parameter metaid="vmar_re58" id="vmar_re58" name="Revere maximal velocity of reaction re58" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re58_s5" id="kmc_re58_s5" name="Michaelis constant of species Stat-1 in reaction re58" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re59" id="re60" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s44" alias="sa51">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s45" alias="sa50">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00166" species="s44">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00167" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00168">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re60 </ci>
<ci> kmc_re60_s44 </ci>
</apply>
<ci> s44 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re60 </ci>
<ci> kmc_re60_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s44 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re60_s44 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re60_s45 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re60" id="vmaf_re60" name="Forward maximal velocity of reaction re60" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re60_s44" id="kmc_re60_s44" name="Michaelis constant of species procaspase-8 in reaction re60" value="1" units="substance"/>
<parameter metaid="vmar_re60" id="vmar_re60" name="Revere maximal velocity of reaction re60" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re60_s45" id="kmc_re60_s45" name="Michaelis constant of species Caspase-8 in reaction re60" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re61" id="re61" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa50">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s25" alias="sa25">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.011629890739541793,-0.04665714992114056 0.9531623214103464,0.18606324557804343</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00169" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00170" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00171">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re61 </ci>
<ci> kmc_re61_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re61 </ci>
<ci> kmc_re61_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re61_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re61_s25 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re61" id="vmaf_re61" name="Forward maximal velocity of reaction re61" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re61_s45" id="kmc_re61_s45" name="Michaelis constant of species Caspase-8 in reaction re61" value="1" units="substance"/>
<parameter metaid="vmar_re61" id="vmar_re61" name="Revere maximal velocity of reaction re61" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re61_s25" id="kmc_re61_s25" name="Michaelis constant of species Bcl-2 in reaction re61" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re62" id="re62" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa50">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s46" alias="sa53">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00172" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00173" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00174">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re62 </ci>
<ci> kmc_re62_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re62 </ci>
<ci> kmc_re62_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re62_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re62_s46 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re62" id="vmaf_re62" name="Forward maximal velocity of reaction re62" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re62_s45" id="kmc_re62_s45" name="Michaelis constant of species Caspase-8 in reaction re62" value="1" units="substance"/>
<parameter metaid="vmar_re62" id="vmar_re62" name="Revere maximal velocity of reaction re62" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re62_s46" id="kmc_re62_s46" name="Michaelis constant of species Cytochrome c  in reaction re62" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re63" id="re63" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa50">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s47" alias="sa54">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.93950468187521,-0.24414629001498245</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00175" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00176" species="s47">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00177">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re63 </ci>
<ci> kmc_re63_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re63 </ci>
<ci> kmc_re63_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re63_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re63_s47 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re63" id="vmaf_re63" name="Forward maximal velocity of reaction re63" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re63_s45" id="kmc_re63_s45" name="Michaelis constant of species Caspase-8 in reaction re63" value="1" units="substance"/>
<parameter metaid="vmar_re63" id="vmar_re63" name="Revere maximal velocity of reaction re63" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re63_s47" id="kmc_re63_s47" name="Michaelis constant of species Bid in reaction re63" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re64" id="re64" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa50">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s48" alias="sa55">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.1844732207933948,-0.39195983245668664</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00178" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00179" species="s48">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00180">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re64 </ci>
<ci> kmc_re64_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re64 </ci>
<ci> kmc_re64_s48 </ci>
</apply>
<ci> s48 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re64_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re64_s48 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re64" id="vmaf_re64" name="Forward maximal velocity of reaction re64" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re64_s45" id="kmc_re64_s45" name="Michaelis constant of species Caspase-8 in reaction re64" value="1" units="substance"/>
<parameter metaid="vmar_re64" id="vmar_re64" name="Revere maximal velocity of reaction re64" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re64_s48" id="kmc_re64_s48" name="Michaelis constant of species S-nitrosylated Caspase in reaction re64" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re65" id="re65" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s47" alias="sa54">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s46" alias="sa53">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.22583535860359127,0.4120044770967226</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s48" aliases="sa55" targetLineIndex="-1,2" editPoints="0.2828554774208074,-0.4532983287346699">
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<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s48" alias="sa55">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00181" species="s47">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa54</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00182" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00183" species="s48">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00184">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re65 </ci>
<ci> kmc_re65_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re65 </ci>
<ci> kmc_re65_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re65_s48 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re65_s47 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re65_s46 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re65_s48 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re65" id="vmaf_re65" name="Forward maximal velocity of reaction re65" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re65_s47" id="kmc_re65_s47" name="Michaelis constant of species Bid in reaction re65" value="1" units="substance"/>
<parameter metaid="vmar_re65" id="vmar_re65" name="Revere maximal velocity of reaction re65" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re65_s46" id="kmc_re65_s46" name="Michaelis constant of species Cytochrome c  in reaction re65" value="1" units="substance"/>
<parameter metaid="kic_1_re65_s48" id="kic_1_re65_s48" name="Inhibitory constant for species S-nitrosylated Caspasewith 1 binding positions of reaction re65" value="1" units="substance"/>
<parameter metaid="kic_2_re65_s48" id="kic_2_re65_s48" name="Inhibitory constant for species S-nitrosylated Caspasewith 2 binding positions of reaction re65" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re66" id="re66" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s25" alias="sa25">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s46" alias="sa53">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.009306607359314878,-0.09205338553182096</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s48" aliases="sa55" targetLineIndex="-1,3" editPoints="0.11120866220719128,-0.372328382525025 1.0296460483601038,-0.0986808869454383">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s48" alias="sa55">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00185" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00186" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00187" species="s48">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00188">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re66 </ci>
<ci> kmc_re66_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re66 </ci>
<ci> kmc_re66_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re66_s48 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re66_s25 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re66_s46 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re66_s48 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re66" id="vmaf_re66" name="Forward maximal velocity of reaction re66" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re66_s25" id="kmc_re66_s25" name="Michaelis constant of species Bcl-2 in reaction re66" value="1" units="substance"/>
<parameter metaid="vmar_re66" id="vmar_re66" name="Revere maximal velocity of reaction re66" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re66_s46" id="kmc_re66_s46" name="Michaelis constant of species Cytochrome c  in reaction re66" value="1" units="substance"/>
<parameter metaid="kic_1_re66_s48" id="kic_1_re66_s48" name="Inhibitory constant for species S-nitrosylated Caspasewith 1 binding positions of reaction re66" value="1" units="substance"/>
<parameter metaid="kic_2_re66_s48" id="kic_2_re66_s48" name="Inhibitory constant for species S-nitrosylated Caspasewith 2 binding positions of reaction re66" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re67" id="re67" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s49" alias="sa56">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s50" alias="sa57">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s51" alias="sa58" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="E"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00189" species="s49">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa56</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00190" species="s51">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00191" species="s50">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00192">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re67 </ci>
<apply>
<times/>
<ci> kic_re67_s49 </ci>
<ci> kmc_re67_s51 </ci>
</apply>
</apply>
<ci> s49 </ci>
<ci> default </ci>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re67 </ci>
<ci> kmc_re67_s50 </ci>
</apply>
<ci> s50 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s50 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re67_s50 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s49 </ci>
<ci> default </ci>
</apply>
<ci> kic_re67_s49 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s49 </ci>
<ci> default </ci>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re67_s49 </ci>
<ci> kmc_re67_s51 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<ci> kic_re67_s51 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re67" id="vmaf_re67" name="Forward maximal velocity of reaction re67" value="1" units="mole_per_second"/>
<parameter metaid="vmar_re67" id="vmar_re67" name="Revere maximal velocity of reaction re67" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re67_s51" id="kmc_re67_s51" name="Michaelis constant of species ICE in reaction re67" value="1" units="substance"/>
<parameter metaid="kmc_re67_s50" id="kmc_re67_s50" name="Michaelis constant of species Mature IL-1β in reaction re67" value="1" units="substance"/>
<parameter metaid="kic_re67_s49" id="kic_re67_s49" name="Inhibitory constant for species pro-IL-1β of reaction re67" value="1" units="substance"/>
<parameter metaid="kic_re67_s51" id="kic_re67_s51" name="Inhibitory constant for species ICE of reaction re67" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re68" id="re68" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s50" alias="sa57">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="4">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.02685289130597912,-0.0015510431751692977 -0.030371709333805397,0.3858839605778755 1.0336735769162084,0.40290684117010545 1.0402977212486788,2.598355492444693E-4</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00193" species="s50">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa57</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00194" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00195">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re68 </ci>
<ci> kmc_re68_s50 </ci>
</apply>
<ci> s50 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re68 </ci>
<ci> kmc_re68_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s50 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re68_s50 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re68_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re68" id="vmaf_re68" name="Forward maximal velocity of reaction re68" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re68_s50" id="kmc_re68_s50" name="Michaelis constant of species Mature IL-1β in reaction re68" value="1" units="substance"/>
<parameter metaid="vmar_re68" id="vmar_re68" name="Revere maximal velocity of reaction re68" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re68_s11" id="kmc_re68_s11" name="Michaelis constant of species IL-1β in reaction re68" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re69" id="re69" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s52" alias="sa59">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s51" alias="sa58">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
<celldesigner:lineDirection index="4" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.02118222251142443,-0.1006829546737309 0.42303959769331456,-0.01646783668868168 0.818475258514477,0.06298985989587047 0.9802545025736635,0.09822320227852588</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00196" species="s52">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00197" species="s51">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00198">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re69 </ci>
<ci> kmc_re69_s52 </ci>
</apply>
<ci> s52 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re69 </ci>
<ci> kmc_re69_s51 </ci>
</apply>
<ci> s51 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s52 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re69_s52 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re69_s51 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re69" id="vmaf_re69" name="Forward maximal velocity of reaction re69" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re69_s52" id="kmc_re69_s52" name="Michaelis constant of species Caspase-1 in reaction re69" value="1" units="substance"/>
<parameter metaid="vmar_re69" id="vmar_re69" name="Revere maximal velocity of reaction re69" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re69_s51" id="kmc_re69_s51" name="Michaelis constant of species ICE in reaction re69" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re70" id="re70" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s53" alias="sa60">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa61">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s51" alias="sa58" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="NNE"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.007686634169166151,-0.09755717371675143 0.7240615338432685,-0.155228056842872</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00199" species="s53">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa60</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00200" species="s51">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa58</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00201" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa61</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00202">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re70 </ci>
<apply>
<times/>
<ci> kic_re70_s53 </ci>
<ci> kmc_re70_s51 </ci>
</apply>
</apply>
<ci> s53 </ci>
<ci> default </ci>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re70 </ci>
<ci> kmc_re70_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re70_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s53 </ci>
<ci> default </ci>
</apply>
<ci> kic_re70_s53 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s53 </ci>
<ci> default </ci>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re70_s53 </ci>
<ci> kmc_re70_s51 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s51 </ci>
<ci> default </ci>
</apply>
<ci> kic_re70_s51 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re70" id="vmaf_re70" name="Forward maximal velocity of reaction re70" value="1" units="mole_per_second"/>
<parameter metaid="vmar_re70" id="vmar_re70" name="Revere maximal velocity of reaction re70" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re70_s51" id="kmc_re70_s51" name="Michaelis constant of species ICE in reaction re70" value="1" units="substance"/>
<parameter metaid="kmc_re70_s9" id="kmc_re70_s9" name="Michaelis constant of species IFNγ in reaction re70" value="1" units="substance"/>
<parameter metaid="kic_re70_s53" id="kic_re70_s53" name="Inhibitory constant for species IL-18 of reaction re70" value="1" units="substance"/>
<parameter metaid="kic_re70_s51" id="kic_re70_s51" name="Inhibitory constant for species ICE of reaction re70" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re72" id="re72" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa61">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
<celldesigner:lineDirection index="3" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.008363479275696584,-0.2262144187159863 1.0414475613998178,-0.2666282668037296 1.0536707102282747,-0.0026135530883910074</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00203" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa61</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00204" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00205">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re72 </ci>
<ci> kmc_re72_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re72 </ci>
<ci> kmc_re72_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re72_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re72_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re72" id="vmaf_re72" name="Forward maximal velocity of reaction re72" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re72_s9" id="kmc_re72_s9" name="Michaelis constant of species IFNγ in reaction re72" value="1" units="substance"/>
<parameter metaid="vmar_re72" id="vmar_re72" name="Revere maximal velocity of reaction re72" value="1" units="mole_per_second"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re73" id="re73" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s52" alias="sa59">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s48" alias="sa55">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00206" species="s52">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00207" species="s48">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa55</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00208">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re73 </ci>
<ci> kmc_re73_s52 </ci>
</apply>
<ci> s52 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re73 </ci>
<ci> kmc_re73_s48 </ci>
</apply>
<ci> s48 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s52 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re73_s52 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s48 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re73_s48 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re73" id="vmaf_re73" name="Forward maximal velocity of reaction re73" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re73_s52" id="kmc_re73_s52" name="Michaelis constant of species Caspase-1 in reaction re73" value="1" units="substance"/>
<parameter metaid="vmar_re73" id="vmar_re73" name="Revere maximal velocity of reaction re73" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re73_s48" id="kmc_re73_s48" name="Michaelis constant of species S-nitrosylated Caspase in reaction re73" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re74" id="re74" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s54" alias="sa62">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.009520168030437759,-0.22656665169936696 0.44948467614000276,-0.625731792871024</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00209" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00210" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00211">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re74 </ci>
<ci> kmc_re74_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re74 </ci>
<ci> kmc_re74_s54 </ci>
</apply>
<ci> s54 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re74_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s54 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re74_s54 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re74" id="vmaf_re74" name="Forward maximal velocity of reaction re74" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re74_s1" id="kmc_re74_s1" name="Michaelis constant of species NO in reaction re74" value="1" units="substance"/>
<parameter metaid="vmar_re74" id="vmar_re74" name="Revere maximal velocity of reaction re74" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re74_s54" id="kmc_re74_s54" name="Michaelis constant of species P53 in reaction re74" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re75" id="re75" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s54" alias="sa62">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s55" alias="sa63">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00212" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00213" species="s55">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00214">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re75 </ci>
<ci> kmc_re75_s54 </ci>
</apply>
<ci> s54 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re75 </ci>
<ci> kmc_re75_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s54 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re75_s54 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re75_s55 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re75" id="vmaf_re75" name="Forward maximal velocity of reaction re75" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re75_s54" id="kmc_re75_s54" name="Michaelis constant of species P53 in reaction re75" value="1" units="substance"/>
<parameter metaid="vmar_re75" id="vmar_re75" name="Revere maximal velocity of reaction re75" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re75_s55" id="kmc_re75_s55" name="Michaelis constant of species Bax in reaction re75" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re76" id="re76" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s55" alias="sa63">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s46" alias="sa53">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.09420350106082909,-0.22969908909009717 0.9621209278428178,0.11311818880540425</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s25" aliases="sa25" targetLineIndex="-1,6" editPoints="0.08489809049412544,-0.27937726697329723">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s25" alias="sa25">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00215" species="s55">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00216" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00217" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00218">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re76 </ci>
<ci> kmc_re76_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re76 </ci>
<ci> kmc_re76_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re76_s25 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re76_s55 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re76_s46 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re76_s25 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re76" id="vmaf_re76" name="Forward maximal velocity of reaction re76" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re76_s55" id="kmc_re76_s55" name="Michaelis constant of species Bax in reaction re76" value="1" units="substance"/>
<parameter metaid="vmar_re76" id="vmar_re76" name="Revere maximal velocity of reaction re76" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re76_s46" id="kmc_re76_s46" name="Michaelis constant of species Cytochrome c  in reaction re76" value="1" units="substance"/>
<parameter metaid="kic_1_re76_s25" id="kic_1_re76_s25" name="Inhibitory constant for species Bcl-2with 1 binding positions of reaction re76" value="1" units="substance"/>
<parameter metaid="kic_2_re76_s25" id="kic_2_re76_s25" name="Inhibitory constant for species Bcl-2with 2 binding positions of reaction re76" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re77" id="re77" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s46" alias="sa53">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s56" alias="sa64">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.8836935311660145,-0.3218830921787301</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00219" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00220" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00221">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re77 </ci>
<ci> kmc_re77_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re77 </ci>
<ci> kmc_re77_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re77_s46 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re77_s56 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re77" id="vmaf_re77" name="Forward maximal velocity of reaction re77" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re77_s46" id="kmc_re77_s46" name="Michaelis constant of species Cytochrome c  in reaction re77" value="1" units="substance"/>
<parameter metaid="vmar_re77" id="vmar_re77" name="Revere maximal velocity of reaction re77" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re77_s56" id="kmc_re77_s56" name="Michaelis constant of species Caspase-3 in reaction re77" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re78" id="re78" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s57" alias="sa66">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s58" alias="sa67">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s59" alias="sa68" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00222" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa66</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00223" species="s59">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa68</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00224" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00225">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re78 </ci>
<apply>
<times/>
<ci> kic_re78_s57 </ci>
<ci> kmc_re78_s59 </ci>
</apply>
</apply>
<ci> s57 </ci>
<ci> default </ci>
<ci> s59 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re78 </ci>
<ci> kmc_re78_s58 </ci>
</apply>
<ci> s58 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re78_s58 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<ci> kic_re78_s57 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
<ci> s59 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re78_s57 </ci>
<ci> kmc_re78_s59 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s59 </ci>
<ci> default </ci>
</apply>
<ci> kic_re78_s59 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re78" id="vmaf_re78" name="Forward maximal velocity of reaction re78" value="1" units="mole_per_second"/>
<parameter metaid="vmar_re78" id="vmar_re78" name="Revere maximal velocity of reaction re78" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re78_s59" id="kmc_re78_s59" name="Michaelis constant of species Apaf1 in reaction re78" value="1" units="substance"/>
<parameter metaid="kmc_re78_s58" id="kmc_re78_s58" name="Michaelis constant of species Caspase-9 in reaction re78" value="1" units="substance"/>
<parameter metaid="kic_re78_s57" id="kic_re78_s57" name="Inhibitory constant for species procaspase-9 of reaction re78" value="1" units="substance"/>
<parameter metaid="kic_re78_s59" id="kic_re78_s59" name="Inhibitory constant for species Apaf1 of reaction re78" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re79" id="re79" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s58" alias="sa67">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s56" alias="sa64">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3815642827507961,0.11306458210609804</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00226" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00227" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00228">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re79 </ci>
<ci> kmc_re79_s58 </ci>
</apply>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re79 </ci>
<ci> kmc_re79_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re79_s58 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re79_s56 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re79" id="vmaf_re79" name="Forward maximal velocity of reaction re79" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re79_s58" id="kmc_re79_s58" name="Michaelis constant of species Caspase-9 in reaction re79" value="1" units="substance"/>
<parameter metaid="vmar_re79" id="vmar_re79" name="Revere maximal velocity of reaction re79" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re79_s56" id="kmc_re79_s56" name="Michaelis constant of species Caspase-3 in reaction re79" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re80" id="re80" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s58" alias="sa67">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s60" alias="sa69"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00229" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00230" species="s60">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa69</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00231">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re80 </ci>
<ci> kmc_re80_s58 </ci>
</apply>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re80 </ci>
<ci> kmc_re80_s60 </ci>
</apply>
<ci> s60 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s58 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s60 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s60 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re80" id="vmaf_re80" name="Forward maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s58" id="kmc_re80_s58" name="Michaelis constant of species Caspase-9 in reaction re80" value="1" units="substance"/>
<parameter metaid="vmar_re80" id="vmar_re80" name="Revere maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s60" id="kmc_re80_s60" name="Michaelis constant of species Caspase 7 in reaction re80" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re81" id="re81" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa50">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s56" alias="sa64">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2056296683680392,0.21852410569068947 0.740404731761716,-0.2800156418482658</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00232" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00233" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00234">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re81 </ci>
<ci> kmc_re81_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re81 </ci>
<ci> kmc_re81_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s56 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re81" id="vmaf_re81" name="Forward maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s45" id="kmc_re81_s45" name="Michaelis constant of species Caspase-8 in reaction re81" value="1" units="substance"/>
<parameter metaid="vmar_re81" id="vmar_re81" name="Revere maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s56" id="kmc_re81_s56" name="Michaelis constant of species Caspase-3 in reaction re81" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re82" id="re82" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s56" alias="sa64">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s61" alias="sa70">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.22410554536340666,-0.2593715897463458</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00235" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00236" species="s61">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa70</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00237">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re82 </ci>
<ci> kmc_re82_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re82 </ci>
<ci> kmc_re82_s61 </ci>
</apply>
<ci> s61 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s56 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s61 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s61 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re82" id="vmaf_re82" name="Forward maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s56" id="kmc_re82_s56" name="Michaelis constant of species Caspase-3 in reaction re82" value="1" units="substance"/>
<parameter metaid="vmar_re82" id="vmar_re82" name="Revere maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s61" id="kmc_re82_s61" name="Michaelis constant of species Apoptosis in reaction re82" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re83" id="re83" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s62" alias="sa71">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00238" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00239" species="s62">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa71</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00240">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re83 </ci>
<ci> kmc_re83_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re83 </ci>
<ci> kmc_re83_s62 </ci>
</apply>
<ci> s62 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s62 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s62 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re83" id="vmaf_re83" name="Forward maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s1" id="kmc_re83_s1" name="Michaelis constant of species NO in reaction re83" value="1" units="substance"/>
<parameter metaid="vmar_re83" id="vmar_re83" name="Revere maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s62" id="kmc_re83_s62" name="Michaelis constant of species T cell in reaction re83" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re84" id="re84" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s46" alias="sa53">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s58" alias="sa67">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2472911866349352,0.10180403527914361 0.39099974236045876,-0.2512296591454226</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00241" species="s46">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa53</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00242" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa67</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00243">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re84 </ci>
<ci> kmc_re84_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re84 </ci>
<ci> kmc_re84_s58 </ci>
</apply>
<ci> s58 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s46 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s58 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s58 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re84" id="vmaf_re84" name="Forward maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s46" id="kmc_re84_s46" name="Michaelis constant of species Cytochrome c  in reaction re84" value="1" units="substance"/>
<parameter metaid="vmar_re84" id="vmar_re84" name="Revere maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s58" id="kmc_re84_s58" name="Michaelis constant of species Caspase-9 in reaction re84" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re85" id="re85" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s39" alias="sa43">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s63" alias="sa73">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.38839645463014155,0.6558304645308304 1.129368368341212,0.2155191764165827</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00244" species="s39">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00245" species="s63">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa73</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00246">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re85 </ci>
<ci> kmc_re85_s39 </ci>
</apply>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re85 </ci>
<ci> kmc_re85_s63 </ci>
</apply>
<ci> s63 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s39 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s63 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re85" id="vmaf_re85" name="Forward maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s39" id="kmc_re85_s39" name="Michaelis constant of species Viral infection in reaction re85" value="1" units="substance"/>
<parameter metaid="vmar_re85" id="vmar_re85" name="Revere maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s63" id="kmc_re85_s63" name="Michaelis constant of species PRRs in reaction re85" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re86" id="re86" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s63" alias="sa73">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s64" alias="sa74">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00247" species="s63">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa73</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00248" species="s64">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa74</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00249">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re86 </ci>
<ci> kmc_re86_s63 </ci>
</apply>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re86 </ci>
<ci> kmc_re86_s64 </ci>
</apply>
<ci> s64 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s63 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s64 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s64 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re86" id="vmaf_re86" name="Forward maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s63" id="kmc_re86_s63" name="Michaelis constant of species PRRs in reaction re86" value="1" units="substance"/>
<parameter metaid="vmar_re86" id="vmar_re86" name="Revere maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s64" id="kmc_re86_s64" name="Michaelis constant of species IRF-3 in reaction re86" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re87" id="re87" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s63" alias="sa73">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s65" alias="sa75">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00250" species="s63">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa73</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00251" species="s65">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa75</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00252">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re87 </ci>
<ci> kmc_re87_s63 </ci>
</apply>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re87 </ci>
<ci> kmc_re87_s65 </ci>
</apply>
<ci> s65 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re87_s63 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s65 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re87_s65 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re87" id="vmaf_re87" name="Forward maximal velocity of reaction re87" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re87_s63" id="kmc_re87_s63" name="Michaelis constant of species PRRs in reaction re87" value="1" units="substance"/>
<parameter metaid="vmar_re87" id="vmar_re87" name="Revere maximal velocity of reaction re87" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re87_s65" id="kmc_re87_s65" name="Michaelis constant of species IRF-7 in reaction re87" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re88" id="re88" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s63" alias="sa73">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s15" alias="sa15">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.005571386779062659,-0.08298570855861209</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00253" species="s63">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa73</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00254" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00255">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re88 </ci>
<ci> kmc_re88_s63 </ci>
</apply>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re88 </ci>
<ci> kmc_re88_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s63 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s63 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s15 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re88" id="vmaf_re88" name="Forward maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s63" id="kmc_re88_s63" name="Michaelis constant of species PRRs in reaction re88" value="1" units="substance"/>
<parameter metaid="vmar_re88" id="vmar_re88" name="Revere maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s15" id="kmc_re88_s15" name="Michaelis constant of species IRF-1 in reaction re88" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re89" id="re89" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s15" alias="sa15">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>1.1351439999689341,-0.21788785286040757 1.170542648787246,-0.030575436005650714</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00256" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00257" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00258">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re89 </ci>
<ci> kmc_re89_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re89 </ci>
<ci> kmc_re89_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s15 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re89" id="vmaf_re89" name="Forward maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s15" id="kmc_re89_s15" name="Michaelis constant of species IRF-1 in reaction re89" value="1" units="substance"/>
<parameter metaid="vmar_re89" id="vmar_re89" name="Revere maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s13" id="kmc_re89_s13" name="Michaelis constant of species IL-12 in reaction re89" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re90" id="re90" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s15" alias="sa15">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>1.0348037340810115,-0.4348969382256399 1.1853525581559716,-0.07610414623587469</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00259" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00260" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00261">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re90 </ci>
<ci> kmc_re90_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re90 </ci>
<ci> kmc_re90_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s15 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re90" id="vmaf_re90" name="Forward maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s15" id="kmc_re90_s15" name="Michaelis constant of species IRF-1 in reaction re90" value="1" units="substance"/>
<parameter metaid="vmar_re90" id="vmar_re90" name="Revere maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s9" id="kmc_re90_s9" name="Michaelis constant of species IFNγ in reaction re90" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re91" id="re91" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s60" alias="sa69">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s56" alias="sa64">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.06190624115302601,0.2691964390444396 1.0118872847159874,0.04665151044856597</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00262" species="s60">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa69</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00263" species="s56">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa64</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00264">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re91 </ci>
<ci> kmc_re91_s60 </ci>
</apply>
<ci> s60 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re91 </ci>
<ci> kmc_re91_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s60 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s60 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s56 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re91" id="vmaf_re91" name="Forward maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s60" id="kmc_re91_s60" name="Michaelis constant of species Caspase 7 in reaction re91" value="1" units="substance"/>
<parameter metaid="vmar_re91" id="vmar_re91" name="Revere maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s56" id="kmc_re91_s56" name="Michaelis constant of species Caspase-3 in reaction re91" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>