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<species metaid="s12" id="s12" name="Antithrombin III" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s13" id="s13" name="Inflammatiory mediators" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s15" id="s15" name="Macrophages" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr9</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s16" id="s16" name="PAR-1" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr10</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s17" id="s17" name="Fibrinogen" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr11</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s18" id="s18" name="Fibrin" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s19" id="s19" name="Clot stabilization" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Clot stabilization</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s22" id="s22" name="Hydroxylation" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s23" id="s23" name="HIF" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s24" id="s24" name="HRE" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr16</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s25" id="s25" name="PAI-1" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr17</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s26" id="s26" name="Aggregation" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr18</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s28" id="s28" name="Thrombosis" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr19</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s29" id="s29" name="EGR-1" compartment="default" initialAmount="1" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr20</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s20" id="s20" name="Hypoxia" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Hypoxia</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re27"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s35" id="s35" name="Leukocyte" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr26</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s36" id="s36" name="Tissue factor" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr27</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s37" id="s37" name="von Willebrand factor " compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr28</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s38" id="s38" name="Factor XIII" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr29</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s39" id="s39" name="FV" compartment="default" initialAmount="0.94" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr30</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s40" id="s40" name="FVIII" compartment="default" initialAmount="1.04" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr31</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s41" id="s41" name="Activated Protein C" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr32</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re34"/>
<celldesigner:catalyzed reaction="re49"/>
<celldesigner:catalyzed reaction="re50"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s42" id="s42" name="Protein C" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr33</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s43" id="s43" name="EPCR" compartment="default" initialAmount="1.01" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr34</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s44" id="s44" name="Thrombomodulin" compartment="default" initialAmount="0.11" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr35</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s45" id="s45" name="Infection" compartment="default" initialAmount="1.02" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>Infection</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s21" id="s21" name="PHD enzymes" compartment="default" initialAmount="0.99" substanceUnits="substance" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr13</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re2" id="re2" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa3">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa1">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00008" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00009" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00163">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re2 </ci>
<ci> kmc_re2_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re2 </ci>
<ci> kmc_re2_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re2" id="vmaf_re2" name="Forward maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s3" id="kmc_re2_s3" name="Michaelis constant of species Neutrophils in reaction re2" value="1" units="substance"/>
<parameter metaid="vmar_re2" id="vmar_re2" name="Revere maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s1" id="kmc_re2_s1" name="Michaelis constant of species NETs in reaction re2" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re3" id="re3" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s4" alias="sa4">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00010" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00011" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00164">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re3 </ci>
<ci> kmc_re3_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re3 </ci>
<ci> kmc_re3_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s4 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re3" id="vmaf_re3" name="Forward maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s1" id="kmc_re3_s1" name="Michaelis constant of species NETs in reaction re3" value="1" units="substance"/>
<parameter metaid="vmar_re3" id="vmar_re3" name="Revere maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s4" id="kmc_re3_s4" name="Michaelis constant of species Extracellular histones in reaction re3" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re4" id="re4" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s4" alias="sa4">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s5" alias="sa5">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00012" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00013" species="s5">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00165">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re4 </ci>
<ci> kmc_re4_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re4 </ci>
<ci> kmc_re4_s5 </ci>
</apply>
<ci> s5 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s4 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s5 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s5 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re4" id="vmaf_re4" name="Forward maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s4" id="kmc_re4_s4" name="Michaelis constant of species Extracellular histones in reaction re4" value="1" units="substance"/>
<parameter metaid="vmar_re4" id="vmar_re4" name="Revere maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s5" id="kmc_re4_s5" name="Michaelis constant of species Sepsis in reaction re4" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re5" id="re5" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s4" alias="sa4">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s6" alias="sa6">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00014" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00015" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00166">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re5 </ci>
<ci> kmc_re5_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re5 </ci>
<ci> kmc_re5_s6 </ci>
</apply>
<ci> s6 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s4 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s6 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re5" id="vmaf_re5" name="Forward maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s4" id="kmc_re5_s4" name="Michaelis constant of species Extracellular histones in reaction re5" value="1" units="substance"/>
<parameter metaid="vmar_re5" id="vmar_re5" name="Revere maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s6" id="kmc_re5_s6" name="Michaelis constant of species ARDS in reaction re5" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re6" id="re6" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa2">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s7" alias="sa7">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00016" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00017" species="s7">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00167">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re6 </ci>
<ci> kmc_re6_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re6 </ci>
<ci> kmc_re6_s7 </ci>
</apply>
<ci> s7 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s7 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s7 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re6" id="vmaf_re6" name="Forward maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s2" id="kmc_re6_s2" name="Michaelis constant of species Cystic Fibrosis in reaction re6" value="1" units="substance"/>
<parameter metaid="vmar_re6" id="vmar_re6" name="Revere maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s7" id="kmc_re6_s7" name="Michaelis constant of species Impaired gas exchange in reaction re6" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re7" id="re7" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s7" alias="sa7">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s8" alias="sa8">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00018" species="s7">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00019" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00168">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re7 </ci>
<ci> kmc_re7_s7 </ci>
</apply>
<ci> s7 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re7 </ci>
<ci> kmc_re7_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s7 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s7 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s8 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re7" id="vmaf_re7" name="Forward maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s7" id="kmc_re7_s7" name="Michaelis constant of species Impaired gas exchange in reaction re7" value="1" units="substance"/>
<parameter metaid="vmar_re7" id="vmar_re7" name="Revere maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s8" id="kmc_re7_s8" name="Michaelis constant of species Secondary Infections in reaction re7" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re9" id="re9" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s8" alias="sa8">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa3">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00020" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00021" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re9 </ci>
<ci> kmc_re9_s8 </ci>
</apply>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re9 </ci>
<ci> kmc_re9_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s8 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s8 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re9" id="vmaf_re9" name="Forward maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s8" id="kmc_re9_s8" name="Michaelis constant of species Secondary Infections in reaction re9" value="1" units="substance"/>
<parameter metaid="vmar_re9" id="vmar_re9" name="Revere maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s3" id="kmc_re9_s3" name="Michaelis constant of species Neutrophils in reaction re9" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re10" id="re10" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00022" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00023" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00170">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re10 </ci>
<ci> kmc_re10_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re10 </ci>
<ci> kmc_re10_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re10" id="vmaf_re10" name="Forward maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s1" id="kmc_re10_s1" name="Michaelis constant of species NETs in reaction re10" value="1" units="substance"/>
<parameter metaid="vmar_re10" id="vmar_re10" name="Revere maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s9" id="kmc_re10_s9" name="Michaelis constant of species Thrombin in reaction re10" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re12" id="re12" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s4" alias="sa4">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00033" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00034" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00171">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re12 </ci>
<ci> kmc_re12_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re12 </ci>
<ci> kmc_re12_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s4 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re12" id="vmaf_re12" name="Forward maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s4" id="kmc_re12_s4" name="Michaelis constant of species Extracellular histones in reaction re12" value="1" units="substance"/>
<parameter metaid="vmar_re12" id="vmar_re12" name="Revere maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s11" id="kmc_re12_s11" name="Michaelis constant of species Platelets in reaction re12" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re13" id="re13" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s12" alias="sa12">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00036" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00172">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re13 </ci>
<ci> kmc_re13_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re13 </ci>
<ci> kmc_re13_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s12 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re13" id="vmaf_re13" name="Forward maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s1" id="kmc_re13_s1" name="Michaelis constant of species NETs in reaction re13" value="1" units="substance"/>
<parameter metaid="vmar_re13" id="vmar_re13" name="Revere maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s12" id="kmc_re13_s12" name="Michaelis constant of species Antithrombin III in reaction re13" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re14" id="re14" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="2">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.12186939722146217,0.17748681976659597 0.5852752253298252,-0.13258315710634783</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00039" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00040" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00173">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re14 </ci>
<ci> kmc_re14_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re14 </ci>
<ci> kmc_re14_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re14" id="vmaf_re14" name="Forward maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s9" id="kmc_re14_s9" name="Michaelis constant of species Thrombin in reaction re14" value="1" units="substance"/>
<parameter metaid="vmar_re14" id="vmar_re14" name="Revere maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s11" id="kmc_re14_s11" name="Michaelis constant of species Platelets in reaction re14" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re15" id="re15" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s11" alias="sa11">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa1">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7646196674337367,0.42602394318781833</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00042" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00043" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00174">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re15 </ci>
<ci> kmc_re15_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re15 </ci>
<ci> kmc_re15_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s11 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re15" id="vmaf_re15" name="Forward maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s11" id="kmc_re15_s11" name="Michaelis constant of species Platelets in reaction re15" value="1" units="substance"/>
<parameter metaid="vmar_re15" id="vmar_re15" name="Revere maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s1" id="kmc_re15_s1" name="Michaelis constant of species NETs in reaction re15" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re16" id="re16" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa3">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00045" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00046" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00175">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re16 </ci>
<ci> kmc_re16_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re16 </ci>
<ci> kmc_re16_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re16" id="vmaf_re16" name="Forward maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s13" id="kmc_re16_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re16" value="1" units="substance"/>
<parameter metaid="vmar_re16" id="vmar_re16" name="Revere maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s3" id="kmc_re16_s3" name="Michaelis constant of species Neutrophils in reaction re16" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re18" id="re18" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa1">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s15" alias="sa15">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00048" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00049" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00176">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re18 </ci>
<ci> kmc_re18_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re18 </ci>
<ci> kmc_re18_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s15 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re18" id="vmaf_re18" name="Forward maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s1" id="kmc_re18_s1" name="Michaelis constant of species NETs in reaction re18" value="1" units="substance"/>
<parameter metaid="vmar_re18" id="vmar_re18" name="Revere maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s15" id="kmc_re18_s15" name="Michaelis constant of species Macrophages in reaction re18" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re19" id="re19" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s15" alias="sa15">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00051" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00052" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00177">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re19 </ci>
<ci> kmc_re19_s15 </ci>
</apply>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re19 </ci>
<ci> kmc_re19_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s15 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s15 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re19" id="vmaf_re19" name="Forward maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s15" id="kmc_re19_s15" name="Michaelis constant of species Macrophages in reaction re19" value="1" units="substance"/>
<parameter metaid="vmar_re19" id="vmar_re19" name="Revere maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s13" id="kmc_re19_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re19" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re20" id="re20" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s1" alias="sa1">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7294499494355371,-0.19506523951689214</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00054" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00055" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00178">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re20 </ci>
<ci> kmc_re20_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re20 </ci>
<ci> kmc_re20_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re20_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re20_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re20" id="vmaf_re20" name="Forward maximal velocity of reaction re20" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re20_s13" id="kmc_re20_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re20" value="1" units="substance"/>
<parameter metaid="vmar_re20" id="vmar_re20" name="Revere maximal velocity of reaction re20" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re20_s1" id="kmc_re20_s1" name="Michaelis constant of species NETs in reaction re20" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re21" id="re21" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s11" alias="sa11">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4488663211507733,0.1396653143069333 0.8803888242555606,-0.16503847829015506</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00057" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00058" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00179">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re21 </ci>
<ci> kmc_re21_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re21 </ci>
<ci> kmc_re21_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s11 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re21" id="vmaf_re21" name="Forward maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s11" id="kmc_re21_s11" name="Michaelis constant of species Platelets in reaction re21" value="1" units="substance"/>
<parameter metaid="vmar_re21" id="vmar_re21" name="Revere maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s9" id="kmc_re21_s9" name="Michaelis constant of species Thrombin in reaction re21" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re22" id="re22" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa16">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00060" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00061" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00180">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re22 </ci>
<ci> kmc_re22_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re22 </ci>
<ci> kmc_re22_s16 </ci>
</apply>
<ci> s16 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s16 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re22" id="vmaf_re22" name="Forward maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s9" id="kmc_re22_s9" name="Michaelis constant of species Thrombin in reaction re22" value="1" units="substance"/>
<parameter metaid="vmar_re22" id="vmar_re22" name="Revere maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s16" id="kmc_re22_s16" name="Michaelis constant of species PAR-1 in reaction re22" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re23" id="re23" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s16" alias="sa16">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s17" alias="sa17">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00063" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00064" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00181">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re23 </ci>
<ci> kmc_re23_s16 </ci>
</apply>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re23 </ci>
<ci> kmc_re23_s17 </ci>
</apply>
<ci> s17 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s16 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s17 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s17 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re23" id="vmaf_re23" name="Forward maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s16" id="kmc_re23_s16" name="Michaelis constant of species PAR-1 in reaction re23" value="1" units="substance"/>
<parameter metaid="vmar_re23" id="vmar_re23" name="Revere maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s17" id="kmc_re23_s17" name="Michaelis constant of species Fibrinogen in reaction re23" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re24" id="re24" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s17" alias="sa17">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s18" alias="sa18">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s38" alias="sa38" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="E"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00066" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00100" species="s38">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00067" species="s18">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00182">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re24 </ci>
<apply>
<times/>
<ci> kic_re24_s17 </ci>
<ci> kmc_re24_s38 </ci>
</apply>
</apply>
<ci> s17 </ci>
<ci> default </ci>
<ci> s38 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re24 </ci>
<ci> kmc_re24_s18 </ci>
</apply>
<ci> s18 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s18 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s17 </ci>
<ci> default </ci>
</apply>
<ci> kic_re24_s17 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s17 </ci>
<ci> default </ci>
<ci> s38 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<ci> kic_re24_s17 </ci>
<ci> kmc_re24_s38 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s38 </ci>
<ci> default </ci>
</apply>
<ci> kic_re24_s38 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re24" id="vmaf_re24" name="Forward maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="vmar_re24" id="vmar_re24" name="Revere maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s38" id="kmc_re24_s38" name="Michaelis constant of species Factor XIII in reaction re24" value="1" units="substance"/>
<parameter metaid="kmc_re24_s18" id="kmc_re24_s18" name="Michaelis constant of species Fibrin in reaction re24" value="1" units="substance"/>
<parameter metaid="kic_re24_s17" id="kic_re24_s17" name="Inhibitory constant for species Fibrinogen of reaction re24" value="1" units="substance"/>
<parameter metaid="kic_re24_s38" id="kic_re24_s38" name="Inhibitory constant for species Factor XIII of reaction re24" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re25" id="re25" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s18" alias="sa18">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.1619158515462793,0.3688758622702437</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00069" species="s18">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00070" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00183">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re25 </ci>
<ci> kmc_re25_s18 </ci>
</apply>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re25 </ci>
<ci> kmc_re25_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s18 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re25" id="vmaf_re25" name="Forward maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s18" id="kmc_re25_s18" name="Michaelis constant of species Fibrin in reaction re25" value="1" units="substance"/>
<parameter metaid="vmar_re25" id="vmar_re25" name="Revere maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s11" id="kmc_re25_s11" name="Michaelis constant of species Platelets in reaction re25" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re26" id="re26" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s18" alias="sa18">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s19" alias="sa19">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00072" species="s18">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00073" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00184">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re26 </ci>
<ci> kmc_re26_s18 </ci>
</apply>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re26 </ci>
<ci> kmc_re26_s19 </ci>
</apply>
<ci> s19 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re26_s18 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s19 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re26_s19 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re26" id="vmaf_re26" name="Forward maximal velocity of reaction re26" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re26_s18" id="kmc_re26_s18" name="Michaelis constant of species Fibrin in reaction re26" value="1" units="substance"/>
<parameter metaid="vmar_re26" id="vmar_re26" name="Revere maximal velocity of reaction re26" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re26_s19" id="kmc_re26_s19" name="Michaelis constant of species Clot stabilization in reaction re26" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re27" id="re27" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s21" alias="sa21">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s22" alias="sa22">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s20" aliases="sa20" targetLineIndex="-1,5">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s20" alias="sa20">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00001" species="s21">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00002" species="s22">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00003" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00185">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re27 </ci>
<ci> kmc_re27_s21 </ci>
</apply>
<ci> s21 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re27 </ci>
<ci> kmc_re27_s22 </ci>
</apply>
<ci> s22 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re27_s20 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s21 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re27_s21 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s22 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re27_s22 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re27_s20 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re27" id="vmaf_re27" name="Forward maximal velocity of reaction re27" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re27_s21" id="kmc_re27_s21" name="Michaelis constant of species PHD enzymes in reaction re27" value="1" units="substance"/>
<parameter metaid="vmar_re27" id="vmar_re27" name="Revere maximal velocity of reaction re27" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re27_s22" id="kmc_re27_s22" name="Michaelis constant of species Hydroxylation in reaction re27" value="1" units="substance"/>
<parameter metaid="kic_1_re27_s20" id="kic_1_re27_s20" name="Inhibitory constant for species Hypoxiawith 1 binding positions of reaction re27" value="1" units="substance"/>
<parameter metaid="kic_2_re27_s20" id="kic_2_re27_s20" name="Inhibitory constant for species Hypoxiawith 2 binding positions of reaction re27" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re28" id="re28" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s20" alias="sa20">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s23" alias="sa23">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00076" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00077" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00186">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re28 </ci>
<ci> kmc_re28_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re28 </ci>
<ci> kmc_re28_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re28_s20 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re28_s23 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re28" id="vmaf_re28" name="Forward maximal velocity of reaction re28" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re28_s20" id="kmc_re28_s20" name="Michaelis constant of species Hypoxia in reaction re28" value="1" units="substance"/>
<parameter metaid="vmar_re28" id="vmar_re28" name="Revere maximal velocity of reaction re28" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re28_s23" id="kmc_re28_s23" name="Michaelis constant of species HIF in reaction re28" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re29" id="re29" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s24" alias="sa24">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00079" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00080" species="s24">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00187">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re29 </ci>
<ci> kmc_re29_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re29 </ci>
<ci> kmc_re29_s24 </ci>
</apply>
<ci> s24 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re29_s23 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s24 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re29_s24 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re29" id="vmaf_re29" name="Forward maximal velocity of reaction re29" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re29_s23" id="kmc_re29_s23" name="Michaelis constant of species HIF in reaction re29" value="1" units="substance"/>
<parameter metaid="vmar_re29" id="vmar_re29" name="Revere maximal velocity of reaction re29" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re29_s24" id="kmc_re29_s24" name="Michaelis constant of species HRE in reaction re29" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re30" id="re30" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s23" alias="sa23">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s25" alias="sa25">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00082" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00083" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00188">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re30 </ci>
<ci> kmc_re30_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re30 </ci>
<ci> kmc_re30_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re30_s23 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re30_s25 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re30" id="vmaf_re30" name="Forward maximal velocity of reaction re30" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re30_s23" id="kmc_re30_s23" name="Michaelis constant of species HIF in reaction re30" value="1" units="substance"/>
<parameter metaid="vmar_re30" id="vmar_re30" name="Revere maximal velocity of reaction re30" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re30_s25" id="kmc_re30_s25" name="Michaelis constant of species PAI-1 in reaction re30" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re31" id="re31" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
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<annotation>
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<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
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<celldesigner:alias>sa26</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00189">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> vmaf_re31 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s11 </ci>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s16 </ci>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s9 </ci>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s13 </ci>
</apply>
<ci> hco_re31 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> vmar_re31 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s26 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s26 </ci>
</apply>
<ci> hco_re31 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s11 </ci>
</apply>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s16 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s16 </ci>
</apply>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s9 </ci>
</apply>
</apply>
<ci> hco_re31 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s13 </ci>
</apply>
</apply>
<ci> hco_re31 </ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s26 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re31_s26 </ci>
</apply>
</apply>
<ci> hco_re31 </ci>
</apply>
</apply>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re31" id="vmaf_re31" name="Forward maximal velocity of reaction re31" value="1" units="mole_per_second"/>
<parameter metaid="hco_re31" id="hco_re31" name="Reaction cooperativity" value="1" units="dimensionless"/>
<parameter metaid="kmc_re31_s11" id="kmc_re31_s11" name="Michaelis constant of species Platelets in reaction re31" value="1" units="substance"/>
<parameter metaid="kmc_re31_s16" id="kmc_re31_s16" name="Michaelis constant of species PAR-1 in reaction re31" value="1" units="substance"/>
<parameter metaid="kmc_re31_s9" id="kmc_re31_s9" name="Michaelis constant of species Thrombin in reaction re31" value="1" units="substance"/>
<parameter metaid="kmc_re31_s13" id="kmc_re31_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re31" value="1" units="substance"/>
<parameter metaid="vmar_re31" id="vmar_re31" name="Revere maximal velocity of reaction re31" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re31_s26" id="kmc_re31_s26" name="Michaelis constant of species Aggregation in reaction re31" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re32" id="re32" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s18" alias="sa18">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00190">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re32 </ci>
<ci> kmc_re32_s18 </ci>
</apply>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re32 </ci>
<ci> kmc_re32_s28 </ci>
</apply>
<ci> s28 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s18 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re32_s18 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s28 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re32_s28 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re32" id="vmaf_re32" name="Forward maximal velocity of reaction re32" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re32_s18" id="kmc_re32_s18" name="Michaelis constant of species Fibrin in reaction re32" value="1" units="substance"/>
<parameter metaid="vmar_re32" id="vmar_re32" name="Revere maximal velocity of reaction re32" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re32_s28" id="kmc_re32_s28" name="Michaelis constant of species Thrombosis in reaction re32" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re33" id="re33" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</speciesReference>
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<kineticLaw metaid="CDMT00191">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re33 </ci>
<ci> kmc_re33_s26 </ci>
</apply>
<ci> s26 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re33 </ci>
<ci> kmc_re33_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s26 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re33_s26 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re33_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re33" id="vmaf_re33" name="Forward maximal velocity of reaction re33" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re33_s26" id="kmc_re33_s26" name="Michaelis constant of species Aggregation in reaction re33" value="1" units="substance"/>
<parameter metaid="vmar_re33" id="vmar_re33" name="Revere maximal velocity of reaction re33" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re33_s9" id="kmc_re33_s9" name="Michaelis constant of species Thrombin in reaction re33" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re34" id="re34" reversible="false">
<annotation>
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<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00097" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00098" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00120" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00192">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re34 </ci>
<ci> kmc_re34_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re34 </ci>
<ci> kmc_re34_s28 </ci>
</apply>
<ci> s28 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re34_s41 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re34_s25 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s28 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re34_s28 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re34_s41 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re34" id="vmaf_re34" name="Forward maximal velocity of reaction re34" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re34_s25" id="kmc_re34_s25" name="Michaelis constant of species PAI-1 in reaction re34" value="1" units="substance"/>
<parameter metaid="vmar_re34" id="vmar_re34" name="Revere maximal velocity of reaction re34" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re34_s28" id="kmc_re34_s28" name="Michaelis constant of species Thrombosis in reaction re34" value="1" units="substance"/>
<parameter metaid="kic_1_re34_s41" id="kic_1_re34_s41" name="Inhibitory constant for species Activated Protein Cwith 1 binding positions of reaction re34" value="1" units="substance"/>
<parameter metaid="kic_2_re34_s41" id="kic_2_re34_s41" name="Inhibitory constant for species Activated Protein Cwith 2 binding positions of reaction re34" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re35" id="re35" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s23" alias="sa23">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s29" alias="sa29">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00101" species="s23">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00102" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00193">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re35 </ci>
<ci> kmc_re35_s23 </ci>
</apply>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re35 </ci>
<ci> kmc_re35_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s23 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re35_s23 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re35_s29 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re35" id="vmaf_re35" name="Forward maximal velocity of reaction re35" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re35_s23" id="kmc_re35_s23" name="Michaelis constant of species HIF in reaction re35" value="1" units="substance"/>
<parameter metaid="vmar_re35" id="vmar_re35" name="Revere maximal velocity of reaction re35" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re35_s29" id="kmc_re35_s29" name="Michaelis constant of species EGR-1 in reaction re35" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re36" id="re36" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s29" alias="sa29">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s28" alias="sa28">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.05917070921389511,-0.22425360739958933 0.9938099152473678,0.02615669366907092</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00104" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00105" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00194">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re36 </ci>
<ci> kmc_re36_s29 </ci>
</apply>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re36 </ci>
<ci> kmc_re36_s28 </ci>
</apply>
<ci> s28 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s29 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re36_s29 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s28 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re36_s28 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re36" id="vmaf_re36" name="Forward maximal velocity of reaction re36" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re36_s29" id="kmc_re36_s29" name="Michaelis constant of species EGR-1 in reaction re36" value="1" units="substance"/>
<parameter metaid="vmar_re36" id="vmar_re36" name="Revere maximal velocity of reaction re36" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re36_s28" id="kmc_re36_s28" name="Michaelis constant of species Thrombosis in reaction re36" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re37" id="re37" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s20" alias="sa20">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.021680456325762876,0.08844375240635727 0.40868784751207876,0.5502129706316119</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00107" species="s20">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00108" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00195">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re37 </ci>
<ci> kmc_re37_s20 </ci>
</apply>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re37 </ci>
<ci> kmc_re37_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s20 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re37_s20 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re37_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re37" id="vmaf_re37" name="Forward maximal velocity of reaction re37" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re37_s20" id="kmc_re37_s20" name="Michaelis constant of species Hypoxia in reaction re37" value="1" units="substance"/>
<parameter metaid="vmar_re37" id="vmar_re37" name="Revere maximal velocity of reaction re37" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re37_s13" id="kmc_re37_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re37" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re39" id="re39" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s28" alias="sa28">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.05527425420679055,-0.452985044156625 1.0402133405286405,-0.33445989432218814</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00110" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00111" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00196">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re39 </ci>
<ci> kmc_re39_s28 </ci>
</apply>
<ci> s28 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re39 </ci>
<ci> kmc_re39_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s28 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re39_s28 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re39_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re39" id="vmaf_re39" name="Forward maximal velocity of reaction re39" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re39_s28" id="kmc_re39_s28" name="Michaelis constant of species Thrombosis in reaction re39" value="1" units="substance"/>
<parameter metaid="vmar_re39" id="vmar_re39" name="Revere maximal velocity of reaction re39" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re39_s13" id="kmc_re39_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re39" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re40" id="re40" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s25" alias="sa25">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.18451146418038,-0.24536200171249978 0.8200078803480828,0.23904071337557853</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00113" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00114" species="s25">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00197">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re40 </ci>
<ci> kmc_re40_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re40 </ci>
<ci> kmc_re40_s25 </ci>
</apply>
<ci> s25 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re40_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s25 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re40_s25 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re40" id="vmaf_re40" name="Forward maximal velocity of reaction re40" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re40_s13" id="kmc_re40_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re40" value="1" units="substance"/>
<parameter metaid="vmar_re40" id="vmar_re40" name="Revere maximal velocity of reaction re40" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re40_s25" id="kmc_re40_s25" name="Michaelis constant of species PAI-1 in reaction re40" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re41" id="re41" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s17" alias="sa17">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.10976484992435154,-0.3418503271389042 1.0163853529565916,-0.049643586819841934</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00116" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00117" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00198">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re41 </ci>
<ci> kmc_re41_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re41 </ci>
<ci> kmc_re41_s17 </ci>
</apply>
<ci> s17 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re41_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s17 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re41_s17 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re41" id="vmaf_re41" name="Forward maximal velocity of reaction re41" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re41_s13" id="kmc_re41_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re41" value="1" units="substance"/>
<parameter metaid="vmar_re41" id="vmar_re41" name="Revere maximal velocity of reaction re41" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re41_s17" id="kmc_re41_s17" name="Michaelis constant of species Fibrinogen in reaction re41" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re42" id="re42" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa35">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s36" alias="sa36">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00119" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa35</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00121" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00199">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re42 </ci>
<ci> kmc_re42_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re42 </ci>
<ci> kmc_re42_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re42_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re42_s36 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re42" id="vmaf_re42" name="Forward maximal velocity of reaction re42" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re42_s35" id="kmc_re42_s35" name="Michaelis constant of species Leukocyte in reaction re42" value="1" units="substance"/>
<parameter metaid="vmar_re42" id="vmar_re42" name="Revere maximal velocity of reaction re42" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re42_s36" id="kmc_re42_s36" name="Michaelis constant of species Tissue factor in reaction re42" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re43" id="re43" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s36" alias="sa36">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7657567213693497,-0.12479379079670694</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00123" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00124" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00200">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re43 </ci>
<ci> kmc_re43_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re43 </ci>
<ci> kmc_re43_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re43_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re43_s9 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re43" id="vmaf_re43" name="Forward maximal velocity of reaction re43" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re43_s36" id="kmc_re43_s36" name="Michaelis constant of species Tissue factor in reaction re43" value="1" units="substance"/>
<parameter metaid="vmar_re43" id="vmar_re43" name="Revere maximal velocity of reaction re43" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re43_s9" id="kmc_re43_s9" name="Michaelis constant of species Thrombin in reaction re43" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re44" id="re44" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa37">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s11" alias="sa11">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00126" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa37</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00127" species="s11">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00201">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re44 </ci>
<ci> kmc_re44_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re44 </ci>
<ci> kmc_re44_s11 </ci>
</apply>
<ci> s11 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re44_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s11 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re44_s11 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re44" id="vmaf_re44" name="Forward maximal velocity of reaction re44" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re44_s37" id="kmc_re44_s37" name="Michaelis constant of species von Willebrand factor  in reaction re44" value="1" units="substance"/>
<parameter metaid="vmar_re44" id="vmar_re44" name="Revere maximal velocity of reaction re44" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re44_s11" id="kmc_re44_s11" name="Michaelis constant of species Platelets in reaction re44" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re45" id="re45" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s13" alias="sa13">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s37" alias="sa37">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.011485589829307585,-0.11135085853213766</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00129" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00130" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa37</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00202">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re45 </ci>
<ci> kmc_re45_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re45 </ci>
<ci> kmc_re45_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re45_s13 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re45_s37 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re45" id="vmaf_re45" name="Forward maximal velocity of reaction re45" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re45_s13" id="kmc_re45_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re45" value="1" units="substance"/>
<parameter metaid="vmar_re45" id="vmar_re45" name="Revere maximal velocity of reaction re45" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re45_s37" id="kmc_re45_s37" name="Michaelis constant of species von Willebrand factor  in reaction re45" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re46" id="re46" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s37" alias="sa37">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s36" alias="sa36">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2775133262859627,-0.4457983401183192</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00132" species="s37">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa37</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00133" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa36</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00203">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re46 </ci>
<ci> kmc_re46_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re46 </ci>
<ci> kmc_re46_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re46_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re46_s36 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re46" id="vmaf_re46" name="Forward maximal velocity of reaction re46" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re46_s37" id="kmc_re46_s37" name="Michaelis constant of species von Willebrand factor  in reaction re46" value="1" units="substance"/>
<parameter metaid="vmar_re46" id="vmar_re46" name="Revere maximal velocity of reaction re46" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re46_s36" id="kmc_re46_s36" name="Michaelis constant of species Tissue factor in reaction re46" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re47" id="re47" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s39" alias="sa39">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.456190449139938,-0.20610141643926738</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00135" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00136" species="s39">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00204">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re47 </ci>
<ci> kmc_re47_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re47 </ci>
<ci> kmc_re47_s39 </ci>
</apply>
<ci> s39 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re47_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re47_s39 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re47" id="vmaf_re47" name="Forward maximal velocity of reaction re47" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re47_s9" id="kmc_re47_s9" name="Michaelis constant of species Thrombin in reaction re47" value="1" units="substance"/>
<parameter metaid="vmar_re47" id="vmar_re47" name="Revere maximal velocity of reaction re47" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re47_s39" id="kmc_re47_s39" name="Michaelis constant of species FV in reaction re47" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re48" id="re48" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s40" alias="sa40">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4677152118694714,-0.3440422397292693</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00138" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00139" species="s40">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00205">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re48 </ci>
<ci> kmc_re48_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re48 </ci>
<ci> kmc_re48_s40 </ci>
</apply>
<ci> s40 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re48_s9 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re48_s40 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re48" id="vmaf_re48" name="Forward maximal velocity of reaction re48" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re48_s9" id="kmc_re48_s9" name="Michaelis constant of species Thrombin in reaction re48" value="1" units="substance"/>
<parameter metaid="vmar_re48" id="vmar_re48" name="Revere maximal velocity of reaction re48" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re48_s40" id="kmc_re48_s40" name="Michaelis constant of species FVIII in reaction re48" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re49" id="re49" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s39" alias="sa39">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.04396045604334553,-0.2330820802242286</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s41" aliases="sa41" targetLineIndex="-1,5">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s41" alias="sa41">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00141" species="s39">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00142" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00143" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00206">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re49 </ci>
<ci> kmc_re49_s39 </ci>
</apply>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re49 </ci>
<ci> kmc_re49_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re49_s41 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s39 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re49_s39 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re49_s9 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re49_s41 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re49" id="vmaf_re49" name="Forward maximal velocity of reaction re49" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re49_s39" id="kmc_re49_s39" name="Michaelis constant of species FV in reaction re49" value="1" units="substance"/>
<parameter metaid="vmar_re49" id="vmar_re49" name="Revere maximal velocity of reaction re49" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re49_s9" id="kmc_re49_s9" name="Michaelis constant of species Thrombin in reaction re49" value="1" units="substance"/>
<parameter metaid="kic_1_re49_s41" id="kic_1_re49_s41" name="Inhibitory constant for species Activated Protein Cwith 1 binding positions of reaction re49" value="1" units="substance"/>
<parameter metaid="kic_2_re49_s41" id="kic_2_re49_s41" name="Inhibitory constant for species Activated Protein Cwith 2 binding positions of reaction re49" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re50" id="re50" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s40" alias="sa40">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s9" alias="sa9">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.21282139847174775,-0.40830368412064644</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s41" aliases="sa41" targetLineIndex="-1,5" editPoints="-0.004795536088092689,-0.08597947464489764 0.9991328591329491,-0.07531021439048757">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s41" alias="sa41">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00145" species="s40">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa40</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00146" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00147" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00207">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re50 </ci>
<ci> kmc_re50_s40 </ci>
</apply>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re50 </ci>
<ci> kmc_re50_s9 </ci>
</apply>
<ci> s9 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re50_s41 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s40 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re50_s40 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re50_s9 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re50_s41 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re50" id="vmaf_re50" name="Forward maximal velocity of reaction re50" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re50_s40" id="kmc_re50_s40" name="Michaelis constant of species FVIII in reaction re50" value="1" units="substance"/>
<parameter metaid="vmar_re50" id="vmar_re50" name="Revere maximal velocity of reaction re50" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re50_s9" id="kmc_re50_s9" name="Michaelis constant of species Thrombin in reaction re50" value="1" units="substance"/>
<parameter metaid="kic_1_re50_s41" id="kic_1_re50_s41" name="Inhibitory constant for species Activated Protein Cwith 1 binding positions of reaction re50" value="1" units="substance"/>
<parameter metaid="kic_2_re50_s41" id="kic_2_re50_s41" name="Inhibitory constant for species Activated Protein Cwith 2 binding positions of reaction re50" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re51" id="re51" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s42" alias="sa42">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s41" alias="sa41">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00149" species="s42">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00150" species="s41">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa41</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00208">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re51 </ci>
<ci> kmc_re51_s42 </ci>
</apply>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re51 </ci>
<ci> kmc_re51_s41 </ci>
</apply>
<ci> s41 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re51_s42 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s41 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re51_s41 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re51" id="vmaf_re51" name="Forward maximal velocity of reaction re51" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re51_s42" id="kmc_re51_s42" name="Michaelis constant of species Protein C in reaction re51" value="1" units="substance"/>
<parameter metaid="vmar_re51" id="vmar_re51" name="Revere maximal velocity of reaction re51" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re51_s41" id="kmc_re51_s41" name="Michaelis constant of species Activated Protein C in reaction re51" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re52" id="re52" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s9" alias="sa9">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s42" alias="sa42">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s44" alias="sa44" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s43" alias="sa43" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3722524824802669,0.1263082394646471</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.1533554356567024,-0.011052304351073516 0.2465053604275662,-0.2704897751227655</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00152" species="s9">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00153" species="s44">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00154" species="s43">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00155" species="s42">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa42</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00209">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> vmaf_re52 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s9 </ci>
</apply>
<ci> hco_re52 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s44 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s44 </ci>
</apply>
<ci> hco_re52 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s43 </ci>
</apply>
<ci> hco_re52 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> vmar_re52 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s42 </ci>
</apply>
<ci> hco_re52 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s9 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s9 </ci>
</apply>
</apply>
<ci> hco_re52 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s44 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s44 </ci>
</apply>
</apply>
<ci> hco_re52 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s43 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s43 </ci>
</apply>
</apply>
<ci> hco_re52 </ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s42 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re52_s42 </ci>
</apply>
</apply>
<ci> hco_re52 </ci>
</apply>
</apply>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re52" id="vmaf_re52" name="Forward maximal velocity of reaction re52" value="1" units="mole_per_second"/>
<parameter metaid="hco_re52" id="hco_re52" name="Reaction cooperativity" value="1" units="dimensionless"/>
<parameter metaid="kmc_re52_s9" id="kmc_re52_s9" name="Michaelis constant of species Thrombin in reaction re52" value="1" units="substance"/>
<parameter metaid="kmc_re52_s44" id="kmc_re52_s44" name="Michaelis constant of species Thrombomodulin in reaction re52" value="1" units="substance"/>
<parameter metaid="kmc_re52_s43" id="kmc_re52_s43" name="Michaelis constant of species EPCR in reaction re52" value="1" units="substance"/>
<parameter metaid="vmar_re52" id="vmar_re52" name="Revere maximal velocity of reaction re52" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re52_s42" id="kmc_re52_s42" name="Michaelis constant of species Protein C in reaction re52" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re53" id="re53" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s45" alias="sa45">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s13" alias="sa13">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00157" species="s45">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa45</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00158" species="s13">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00210">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re53 </ci>
<ci> kmc_re53_s45 </ci>
</apply>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re53 </ci>
<ci> kmc_re53_s13 </ci>
</apply>
<ci> s13 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s45 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re53_s45 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s13 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re53_s13 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re53" id="vmaf_re53" name="Forward maximal velocity of reaction re53" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re53_s45" id="kmc_re53_s45" name="Michaelis constant of species Infection in reaction re53" value="1" units="substance"/>
<parameter metaid="vmar_re53" id="vmar_re53" name="Revere maximal velocity of reaction re53" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re53_s13" id="kmc_re53_s13" name="Michaelis constant of species Inflammatiory mediators in reaction re53" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>