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<celldesigner:boxSize width="80.0" height="60.0"/>
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<celldesigner:speciesAlias id="sa24" species="s98">
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<celldesigner:bounds x="35.0" y="464.0" w="80.0" h="40.0"/>
<celldesigner:font size="12"/>
<celldesigner:view state="usual"/>
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<celldesigner:paint color="3fff0000" scheme="Color"/>
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</celldesigner:speciesAlias>
<celldesigner:speciesAlias id="sa25" species="s99">
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<celldesigner:bounds x="219.0" y="481.0" w="80.0" h="40.0"/>
<celldesigner:font size="12"/>
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<celldesigner:boxSize width="80.0" height="40.0"/>
<celldesigner:singleLine width="1.0"/>
<celldesigner:paint color="ffccffcc" scheme="Color"/>
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<celldesigner:boxSize width="80.0" height="60.0"/>
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<celldesigner:paint color="3fff0000" scheme="Color"/>
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</celldesigner:speciesAlias>
</celldesigner:listOfSpeciesAliases>
<celldesigner:listOfGroups/>
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<celldesigner:protein id="pr2" name="IL-1β" type="GENERIC"/>
<celldesigner:protein id="pr3" name="IL-6" type="GENERIC"/>
<celldesigner:protein id="pr4" name="TNFα" type="GENERIC"/>
<celldesigner:protein id="pr5" name="NLRP3" type="GENERIC"/>
<celldesigner:protein id="pr6" name="T cells" type="GENERIC"/>
<celldesigner:protein id="pr7" name="Macrophage" type="GENERIC"/>
<celldesigner:protein id="pr8" name="Neutrophills" type="GENERIC"/>
<celldesigner:protein id="pr9" name="IFNγ " type="GENERIC"/>
<celldesigner:protein id="pr10" name="Cytokine Storm" type="GENERIC"/>
<celldesigner:protein id="pr11" name="IL-2" type="GENERIC"/>
<celldesigner:protein id="pr12" name="MCP-1" type="GENERIC"/>
<celldesigner:protein id="pr13" name="DAMPs" type="GENERIC"/>
<celldesigner:protein id="pr14" name="IL-18" type="GENERIC"/>
<celldesigner:protein id="pr15" name="Degradation" type="GENERIC"/>
<celldesigner:protein id="pr16" name="TLR" type="GENERIC"/>
<celldesigner:protein id="pr17" name="NFkB" type="GENERIC"/>
<celldesigner:protein id="pr18" name="Dendritic cells" type="GENERIC"/>
<celldesigner:protein id="pr19" name="IL-12" type="GENERIC"/>
<celldesigner:protein id="pr20" name="ROS" type="GENERIC"/>
<celldesigner:protein id="pr21" name="IL-21" type="GENERIC"/>
<celldesigner:protein id="pr22" name="NK cells" type="GENERIC"/>
<celldesigner:protein id="pr23" name="PPRs" type="GENERIC"/>
<celldesigner:protein id="pr24" name="Multi-Organ Failure" type="GENERIC"/>
<celldesigner:protein id="pr25" name="PI3K" type="GENERIC"/>
<celldesigner:protein id="pr26" name="AKT" type="GENERIC"/>
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<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
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</annotation>
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<unit metaid="CDMT00069" kind="mole"/>
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<unit metaid="CDMT00070" kind="litre"/>
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</unitDefinition>
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</unitDefinition>
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<unit metaid="CDMT00073" kind="second"/>
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</unitDefinition>
<unitDefinition metaid="mole_per_second" id="mole_per_second" name="mole per second">
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<unit metaid="CDMT00074" kind="mole">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00074">
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<rdf:li rdf:resource="urn:miriam:obo.unit:UO%3A0000013"/>
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<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00005">
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</rdf:Bag>
</bqbiol:is>
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</unitDefinition>
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</listOfCompartments>
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<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
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</annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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</annotation>
</species>
<species metaid="s35" id="s35" name="TNFα" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr4</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s84" id="s84" name="NLRP3" compartment="default" initialAmount="0.01" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr5</celldesigner:proteinReference>
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</celldesigner:extension>
</annotation>
</species>
<species metaid="s86" id="s86" name="T cells" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:proteinReference>pr6</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s87" id="s87" name="Macrophage" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr7</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s88" id="s88" name="Neutrophills" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s89" id="s89" name="IFNγ " compartment="default" initialAmount="0.06" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr9</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s90" id="s90" name="Cytokine Storm" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
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<celldesigner:proteinReference>pr10</celldesigner:proteinReference>
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</annotation>
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</annotation>
</species>
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</annotation>
</species>
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<celldesigner:proteinReference>pr14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s1" id="s1" name="Degradation" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr15</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s97" id="s97" name="TLR" compartment="default" initialAmount="0.01" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
<annotation>
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<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
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<celldesigner:proteinReference>pr16</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s85" id="s85" name="NFkB" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
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<celldesigner:proteinReference>pr17</celldesigner:proteinReference>
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</annotation>
</species>
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</annotation>
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</annotation>
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</annotation>
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</annotation>
</species>
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</annotation>
</species>
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<annotation>
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<celldesigner:proteinReference>pr24</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s98" id="s98" name="PI3K" compartment="default" initialAmount="0" substanceUnits="substance" hasOnlySubstanceUnits="true" charge="0">
<annotation>
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<celldesigner:proteinReference>pr25</celldesigner:proteinReference>
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</annotation>
</species>
<species metaid="s99" id="s99" name="AKT" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
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</species>
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<annotation>
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<celldesigner:editPoints>0.42308178885445,-0.006736668986020877 0.42308178885445,-0.006736668986020877</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
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<annotation>
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<celldesigner:alias>sa0</celldesigner:alias>
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</annotation>
</speciesReference>
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<speciesReference metaid="CDMT00177" species="s1">
<annotation>
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</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00076">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re80 </ci>
<ci> kmc_re80_s30 </ci>
</apply>
<ci> s30 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re80 </ci>
<ci> kmc_re80_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s30 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s30 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re80_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re80" id="vmaf_re80" name="Forward maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s30" id="kmc_re80_s30" name="Michaelis constant of species type 2 pneumocytes in reaction re80" value="1" units="substance"/>
<parameter metaid="vmar_re80" id="vmar_re80" name="Revere maximal velocity of reaction re80" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re80_s1" id="kmc_re80_s1" name="Michaelis constant of species Degradation in reaction re80" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re83" id="re81" name="re81" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re81</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa14">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s96" alias="sa12">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4437805785403468,0.0752373007462861 0.4437805785403468,0.0752373007462861</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00178" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00179" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00077">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re81 </ci>
<ci> kmc_re81_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re81 </ci>
<ci> kmc_re81_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re81_s96 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re81" id="vmaf_re81" name="Forward maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s1" id="kmc_re81_s1" name="Michaelis constant of species Degradation in reaction re81" value="1" units="substance"/>
<parameter metaid="vmar_re81" id="vmar_re81" name="Revere maximal velocity of reaction re81" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re81_s96" id="kmc_re81_s96" name="Michaelis constant of species DAMPs in reaction re81" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re40" id="re82" name="re82" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re82</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa12">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa5">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3668824862415023,0.015182907089672959 0.3668824862415023,0.015182907089672959</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00180" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00181" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00078">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re82 </ci>
<ci> kmc_re82_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re82 </ci>
<ci> kmc_re82_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re82_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re82" id="vmaf_re82" name="Forward maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s96" id="kmc_re82_s96" name="Michaelis constant of species DAMPs in reaction re82" value="1" units="substance"/>
<parameter metaid="vmar_re82" id="vmar_re82" name="Revere maximal velocity of reaction re82" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re82_s86" id="kmc_re82_s86" name="Michaelis constant of species T cells in reaction re82" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re41" id="re83" name="re83" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re83</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa12">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa17">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3358720487433356,0.2566641279512565 0.3358720487433356,0.2566641279512565</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00182" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00183" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00079">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re83 </ci>
<ci> kmc_re83_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re83 </ci>
<ci> kmc_re83_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re83_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re83" id="vmaf_re83" name="Forward maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s96" id="kmc_re83_s96" name="Michaelis constant of species DAMPs in reaction re83" value="1" units="substance"/>
<parameter metaid="vmar_re83" id="vmar_re83" name="Revere maximal velocity of reaction re83" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re83_s2" id="kmc_re83_s2" name="Michaelis constant of species Dendritic cells in reaction re83" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re42" id="re84" name="re84" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re84</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa12">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s88" alias="sa7">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.04220398593200514,-1.0539273153575595 -0.04220398593200514,-1.0539273153575595</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00184" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00185" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00080">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re84 </ci>
<ci> kmc_re84_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re84 </ci>
<ci> kmc_re84_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re84_s88 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re84" id="vmaf_re84" name="Forward maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s96" id="kmc_re84_s96" name="Michaelis constant of species DAMPs in reaction re84" value="1" units="substance"/>
<parameter metaid="vmar_re84" id="vmar_re84" name="Revere maximal velocity of reaction re84" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re84_s88" id="kmc_re84_s88" name="Michaelis constant of species Neutrophills in reaction re84" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re43" id="re85" name="re85" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re85</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa12">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa6">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.44442981301027096,0.23307874637871961 0.44442981301027096,0.23307874637871961</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00186" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00187" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00081">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re85 </ci>
<ci> kmc_re85_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re85 </ci>
<ci> kmc_re85_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re85_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re85" id="vmaf_re85" name="Forward maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s96" id="kmc_re85_s96" name="Michaelis constant of species DAMPs in reaction re85" value="1" units="substance"/>
<parameter metaid="vmar_re85" id="vmar_re85" name="Revere maximal velocity of reaction re85" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re85_s87" id="kmc_re85_s87" name="Michaelis constant of species Macrophage in reaction re85" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="CDMT00100" id="re86" name="re86" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re86</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s96" alias="sa12">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s84" alias="sa4">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4125751238885176,-0.12304502161459263 0.4125751238885176,-0.12304502161459263</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00188" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00189" species="s84">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00082">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re86 </ci>
<ci> kmc_re86_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re86 </ci>
<ci> kmc_re86_s84 </ci>
</apply>
<ci> s84 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re86_s84 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re86" id="vmaf_re86" name="Forward maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s96" id="kmc_re86_s96" name="Michaelis constant of species DAMPs in reaction re86" value="1" units="substance"/>
<parameter metaid="vmar_re86" id="vmar_re86" name="Revere maximal velocity of reaction re86" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re86_s84" id="kmc_re86_s84" name="Michaelis constant of species NLRP3 in reaction re86" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="CDMT00103" id="re87" name="re87" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re87</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s84" alias="sa4">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
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</celldesigner:listOfLineDirection>
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</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00001" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00002">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> kcat_re87_s85 </ci>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<apply>
<plus/>
<ci> kmc_re87_s84_s85 </ci>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="kcat_re87_s85" id="kcat_re87_s85" name="Substrate catalytic rate constant of enzyme NFkB in reaction re87" value="1" units="per_second"/>
<parameter metaid="kmc_re87_s84_s85" id="kmc_re87_s84_s85" name="Michaelis constant of species NLRP3 and enzyme NFkB in reaction re87" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re47" id="re88" name="re88" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re88</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa13">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
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<annotation>
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</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00193" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00084">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re88 </ci>
<ci> kmc_re88_s84 </ci>
</apply>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re88 </ci>
<ci> kmc_re88_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s84 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s84 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re88_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re88" id="vmaf_re88" name="Forward maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s84" id="kmc_re88_s84" name="Michaelis constant of species NLRP3 in reaction re88" value="1" units="substance"/>
<parameter metaid="vmar_re88" id="vmar_re88" name="Revere maximal velocity of reaction re88" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re88_s101" id="kmc_re88_s101" name="Michaelis constant of species IL-18 in reaction re88" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re50" id="re89" name="re89" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re89</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s97" alias="sa15">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5926041019266624,-0.1819453076445008 0.5926041019266624,-0.1819453076445008</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00194" species="s96">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00195" species="s97">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00085">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re89 </ci>
<ci> kmc_re89_s96 </ci>
</apply>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re89 </ci>
<ci> kmc_re89_s97 </ci>
</apply>
<ci> s97 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s96 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s96 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re89_s97 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re89" id="vmaf_re89" name="Forward maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s96" id="kmc_re89_s96" name="Michaelis constant of species DAMPs in reaction re89" value="1" units="substance"/>
<parameter metaid="vmar_re89" id="vmar_re89" name="Revere maximal velocity of reaction re89" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re89_s97" id="kmc_re89_s97" name="Michaelis constant of species TLR in reaction re89" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re51" id="re90" name="re90" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re90</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.3923052953791446,0.07899994501163876 0.3923052953791446,0.07899994501163876</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00196" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00197" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00086">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re90 </ci>
<ci> kmc_re90_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re90 </ci>
<ci> kmc_re90_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re90_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re90" id="vmaf_re90" name="Forward maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s86" id="kmc_re90_s86" name="Michaelis constant of species T cells in reaction re90" value="1" units="substance"/>
<parameter metaid="vmar_re90" id="vmar_re90" name="Revere maximal velocity of reaction re90" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re90_s33" id="kmc_re90_s33" name="Michaelis constant of species IL-1β in reaction re90" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re52" id="re91" name="re91" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re91</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2959124706244942,0.0019262626651768144 0.2959124706244942,0.0019262626651768144</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00198" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00199" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00087">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re91 </ci>
<ci> kmc_re91_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re91 </ci>
<ci> kmc_re91_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re91_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re91" id="vmaf_re91" name="Forward maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s86" id="kmc_re91_s86" name="Michaelis constant of species T cells in reaction re91" value="1" units="substance"/>
<parameter metaid="vmar_re91" id="vmar_re91" name="Revere maximal velocity of reaction re91" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re91_s35" id="kmc_re91_s35" name="Michaelis constant of species TNFα in reaction re91" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re53" id="re92" name="re92" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re92</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa13">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2734426229508182,1.0878688524590165 0.2734426229508182,1.0878688524590165</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00200" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00201" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00088">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re92 </ci>
<ci> kmc_re92_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re92 </ci>
<ci> kmc_re92_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re92_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re92_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re92" id="vmaf_re92" name="Forward maximal velocity of reaction re92" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re92_s86" id="kmc_re92_s86" name="Michaelis constant of species T cells in reaction re92" value="1" units="substance"/>
<parameter metaid="vmar_re92" id="vmar_re92" name="Revere maximal velocity of reaction re92" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re92_s101" id="kmc_re92_s101" name="Michaelis constant of species IL-18 in reaction re92" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re114" id="re93" name="re93" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re93</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa2">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.17571428571428616,0.015714285714285126 0.17571428571428616,0.015714285714285126</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00202" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00203" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00089">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re93 </ci>
<ci> kmc_re93_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re93 </ci>
<ci> kmc_re93_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re93_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re93_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re93" id="vmaf_re93" name="Forward maximal velocity of reaction re93" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re93_s86" id="kmc_re93_s86" name="Michaelis constant of species T cells in reaction re93" value="1" units="substance"/>
<parameter metaid="vmar_re93" id="vmar_re93" name="Revere maximal velocity of reaction re93" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re93_s34" id="kmc_re93_s34" name="Michaelis constant of species IL-6 in reaction re93" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re55" id="re94" name="re94" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re94</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa6">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5404001194386385,-0.30677814272917336 0.5404001194386385,-0.30677814272917336</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00204" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00205" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00090">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re94 </ci>
<ci> kmc_re94_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re94 </ci>
<ci> kmc_re94_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re94_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re94_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re94" id="vmaf_re94" name="Forward maximal velocity of reaction re94" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re94_s87" id="kmc_re94_s87" name="Michaelis constant of species Macrophage in reaction re94" value="1" units="substance"/>
<parameter metaid="vmar_re94" id="vmar_re94" name="Revere maximal velocity of reaction re94" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re94_s33" id="kmc_re94_s33" name="Michaelis constant of species IL-1β in reaction re94" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re57" id="re95" name="re95" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re95</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa6">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa2">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6046034639927074,0.1697812215132184 0.6046034639927074,0.1697812215132184</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00206" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00207" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00091">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re95 </ci>
<ci> kmc_re95_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re95 </ci>
<ci> kmc_re95_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re95_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re95_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re95" id="vmaf_re95" name="Forward maximal velocity of reaction re95" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re95_s87" id="kmc_re95_s87" name="Michaelis constant of species Macrophage in reaction re95" value="1" units="substance"/>
<parameter metaid="vmar_re95" id="vmar_re95" name="Revere maximal velocity of reaction re95" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re95_s34" id="kmc_re95_s34" name="Michaelis constant of species IL-6 in reaction re95" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re58" id="re96" name="re96" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re96</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa6">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6450311376195081,0.6002982194544337 0.6450311376195081,0.6002982194544337</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00208" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00209" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00092">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re96 </ci>
<ci> kmc_re96_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re96 </ci>
<ci> kmc_re96_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re96_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re96_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re96" id="vmaf_re96" name="Forward maximal velocity of reaction re96" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re96_s87" id="kmc_re96_s87" name="Michaelis constant of species Macrophage in reaction re96" value="1" units="substance"/>
<parameter metaid="vmar_re96" id="vmar_re96" name="Revere maximal velocity of reaction re96" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re96_s35" id="kmc_re96_s35" name="Michaelis constant of species TNFα in reaction re96" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re59" id="re97" name="re97" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re97</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa17">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5942350332594231,-0.3791574279379155 0.5942350332594231,-0.3791574279379155</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00210" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00211" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00093">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re97 </ci>
<ci> kmc_re97_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re97 </ci>
<ci> kmc_re97_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re97_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re97_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re97" id="vmaf_re97" name="Forward maximal velocity of reaction re97" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re97_s2" id="kmc_re97_s2" name="Michaelis constant of species Dendritic cells in reaction re97" value="1" units="substance"/>
<parameter metaid="vmar_re97" id="vmar_re97" name="Revere maximal velocity of reaction re97" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re97_s33" id="kmc_re97_s33" name="Michaelis constant of species IL-1β in reaction re97" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re60" id="re98" name="re98" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re98</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa17">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s34" alias="sa2">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.26521962496789087,0.15091189314153652 0.26521962496789087,0.15091189314153652</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00212" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00213" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re98 </ci>
<ci> kmc_re98_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re98 </ci>
<ci> kmc_re98_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re98_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re98_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re98" id="vmaf_re98" name="Forward maximal velocity of reaction re98" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re98_s2" id="kmc_re98_s2" name="Michaelis constant of species Dendritic cells in reaction re98" value="1" units="substance"/>
<parameter metaid="vmar_re98" id="vmar_re98" name="Revere maximal velocity of reaction re98" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re98_s34" id="kmc_re98_s34" name="Michaelis constant of species IL-6 in reaction re98" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re61" id="re99" name="re99" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re99</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa17">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.2869616693799024,0.16027822998372 0.2869616693799024,0.16027822998372</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00214" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00215" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00095">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re99 </ci>
<ci> kmc_re99_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re99 </ci>
<ci> kmc_re99_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re99_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re99_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re99" id="vmaf_re99" name="Forward maximal velocity of reaction re99" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re99_s2" id="kmc_re99_s2" name="Michaelis constant of species Dendritic cells in reaction re99" value="1" units="substance"/>
<parameter metaid="vmar_re99" id="vmar_re99" name="Revere maximal velocity of reaction re99" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re99_s35" id="kmc_re99_s35" name="Michaelis constant of species TNFα in reaction re99" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re62" id="re100" name="re100" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re100</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa7">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.33872878010264484,-0.05112514804579593 0.33872878010264484,-0.05112514804579593</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00216" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00217" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00096">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re100 </ci>
<ci> kmc_re100_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re100 </ci>
<ci> kmc_re100_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re100_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re100_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re100" id="vmaf_re100" name="Forward maximal velocity of reaction re100" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re100_s88" id="kmc_re100_s88" name="Michaelis constant of species Neutrophills in reaction re100" value="1" units="substance"/>
<parameter metaid="vmar_re100" id="vmar_re100" name="Revere maximal velocity of reaction re100" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re100_s35" id="kmc_re100_s35" name="Michaelis constant of species TNFα in reaction re100" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re63" id="re101" name="re101" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re101</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa7">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.28248113998323543,0.041492036881811245 0.28248113998323543,0.041492036881811245</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00218" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00219" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00097">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re101 </ci>
<ci> kmc_re101_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re101 </ci>
<ci> kmc_re101_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re101_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re101_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re101" id="vmaf_re101" name="Forward maximal velocity of reaction re101" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re101_s88" id="kmc_re101_s88" name="Michaelis constant of species Neutrophills in reaction re101" value="1" units="substance"/>
<parameter metaid="vmar_re101" id="vmar_re101" name="Revere maximal velocity of reaction re101" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re101_s33" id="kmc_re101_s33" name="Michaelis constant of species IL-1β in reaction re101" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re64" id="re102" name="re102" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re102</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa7">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa18">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5313367711225712,0.27508925029749953 0.5313367711225712,0.27508925029749953</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00220" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00221" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00098">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re102 </ci>
<ci> kmc_re102_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re102 </ci>
<ci> kmc_re102_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re102_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re102_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re102" id="vmaf_re102" name="Forward maximal velocity of reaction re102" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re102_s88" id="kmc_re102_s88" name="Michaelis constant of species Neutrophills in reaction re102" value="1" units="substance"/>
<parameter metaid="vmar_re102" id="vmar_re102" name="Revere maximal velocity of reaction re102" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re102_s3" id="kmc_re102_s3" name="Michaelis constant of species IL-12 in reaction re102" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re65" id="re103" name="re103" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re103</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s88" alias="sa7">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa11">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.33402526928294707,-0.11282914630359109 0.33402526928294707,-0.11282914630359109</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00222" species="s88">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00223" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re103 </ci>
<ci> kmc_re103_s88 </ci>
</apply>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re103 </ci>
<ci> kmc_re103_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s88 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re103_s88 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re103_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re103" id="vmaf_re103" name="Forward maximal velocity of reaction re103" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re103_s88" id="kmc_re103_s88" name="Michaelis constant of species Neutrophills in reaction re103" value="1" units="substance"/>
<parameter metaid="vmar_re103" id="vmar_re103" name="Revere maximal velocity of reaction re103" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re103_s94" id="kmc_re103_s94" name="Michaelis constant of species MCP-1 in reaction re103" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re66" id="re104" name="re104" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re104</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s2" alias="sa17">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa18">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6334179483350741,-0.8569508735254576 0.6334179483350741,-0.8569508735254576</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00224" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00225" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00101">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re104 </ci>
<ci> kmc_re104_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re104 </ci>
<ci> kmc_re104_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re104_s2 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re104_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re104" id="vmaf_re104" name="Forward maximal velocity of reaction re104" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re104_s2" id="kmc_re104_s2" name="Michaelis constant of species Dendritic cells in reaction re104" value="1" units="substance"/>
<parameter metaid="vmar_re104" id="vmar_re104" name="Revere maximal velocity of reaction re104" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re104_s3" id="kmc_re104_s3" name="Michaelis constant of species IL-12 in reaction re104" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re67" id="re105" name="re105" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re105</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s87" alias="sa6">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa18">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.17137386309238778,-0.7860220201053156 0.17137386309238778,-0.7860220201053156</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00226" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00227" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00102">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re105 </ci>
<ci> kmc_re105_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re105 </ci>
<ci> kmc_re105_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re105_s87 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re105_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re105" id="vmaf_re105" name="Forward maximal velocity of reaction re105" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re105_s87" id="kmc_re105_s87" name="Michaelis constant of species Macrophage in reaction re105" value="1" units="substance"/>
<parameter metaid="vmar_re105" id="vmar_re105" name="Revere maximal velocity of reaction re105" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re105_s3" id="kmc_re105_s3" name="Michaelis constant of species IL-12 in reaction re105" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re68" id="re106" name="re106" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re106</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s93" alias="sa10">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>1.5076923076923094,0.4615384615384617 1.5076923076923094,0.4615384615384617</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00228" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00229" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00104">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re106 </ci>
<ci> kmc_re106_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re106 </ci>
<ci> kmc_re106_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re106_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re106_s93 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re106" id="vmaf_re106" name="Forward maximal velocity of reaction re106" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re106_s86" id="kmc_re106_s86" name="Michaelis constant of species T cells in reaction re106" value="1" units="substance"/>
<parameter metaid="vmar_re106" id="vmar_re106" name="Revere maximal velocity of reaction re106" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re106_s93" id="kmc_re106_s93" name="Michaelis constant of species IL-2 in reaction re106" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re69" id="re107" name="re107" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re107</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa8">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
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<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>-0.0853577371048253,-0.9302828618968384 -0.0853577371048253,-0.9302828618968384</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00230" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00231" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00105">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re107 </ci>
<ci> kmc_re107_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re107 </ci>
<ci> kmc_re107_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re107_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re107_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re107" id="vmaf_re107" name="Forward maximal velocity of reaction re107" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re107_s86" id="kmc_re107_s86" name="Michaelis constant of species T cells in reaction re107" value="1" units="substance"/>
<parameter metaid="vmar_re107" id="vmar_re107" name="Revere maximal velocity of reaction re107" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re107_s89" id="kmc_re107_s89" name="Michaelis constant of species IFNγ  in reaction re107" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re70" id="re108" name="re108" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re108</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.35337999631608064,-0.33753914164671217 0.35337999631608064,-0.33753914164671217</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00232" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00233" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00106">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re108 </ci>
<ci> kmc_re108_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re108 </ci>
<ci> kmc_re108_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re108_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re108_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re108" id="vmaf_re108" name="Forward maximal velocity of reaction re108" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re108_s85" id="kmc_re108_s85" name="Michaelis constant of species NFkB in reaction re108" value="1" units="substance"/>
<parameter metaid="vmar_re108" id="vmar_re108" name="Revere maximal velocity of reaction re108" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re108_s35" id="kmc_re108_s35" name="Michaelis constant of species TNFα in reaction re108" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re71" id="re109" name="re109" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re109</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s33" alias="sa1">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5368036015756896,0.4227912211592576 0.5368036015756896,0.4227912211592576</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00234" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00235" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00107">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re109 </ci>
<ci> kmc_re109_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re109 </ci>
<ci> kmc_re109_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re109_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re109_s33 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re109" id="vmaf_re109" name="Forward maximal velocity of reaction re109" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re109_s85" id="kmc_re109_s85" name="Michaelis constant of species NFkB in reaction re109" value="1" units="substance"/>
<parameter metaid="vmar_re109" id="vmar_re109" name="Revere maximal velocity of reaction re109" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re109_s33" id="kmc_re109_s33" name="Michaelis constant of species IL-1β in reaction re109" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re72" id="re110" name="re110" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re110</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s93" alias="sa10">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5455971369239607,-0.19438430610170965 0.5455971369239607,-0.19438430610170965</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00236" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00237" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00108">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re110 </ci>
<ci> kmc_re110_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re110 </ci>
<ci> kmc_re110_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re110_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re110_s93 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re110" id="vmaf_re110" name="Forward maximal velocity of reaction re110" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re110_s85" id="kmc_re110_s85" name="Michaelis constant of species NFkB in reaction re110" value="1" units="substance"/>
<parameter metaid="vmar_re110" id="vmar_re110" name="Revere maximal velocity of reaction re110" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re110_s93" id="kmc_re110_s93" name="Michaelis constant of species IL-2 in reaction re110" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re73" id="re111" name="re111" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re111</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa8">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.48697937405431246,0.003105837381540244 0.48697937405431246,0.003105837381540244</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00238" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00239" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00109">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re111 </ci>
<ci> kmc_re111_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re111 </ci>
<ci> kmc_re111_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re111_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re111_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re111" id="vmaf_re111" name="Forward maximal velocity of reaction re111" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re111_s85" id="kmc_re111_s85" name="Michaelis constant of species NFkB in reaction re111" value="1" units="substance"/>
<parameter metaid="vmar_re111" id="vmar_re111" name="Revere maximal velocity of reaction re111" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re111_s89" id="kmc_re111_s89" name="Michaelis constant of species IFNγ  in reaction re111" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re74" id="re112" name="re112" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re112</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s3" alias="sa18">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.38852654129969055,-0.04037134015710553 0.38852654129969055,-0.04037134015710553</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00240" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00241" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00110">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re112 </ci>
<ci> kmc_re112_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re112 </ci>
<ci> kmc_re112_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re112_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re112_s3 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re112" id="vmaf_re112" name="Forward maximal velocity of reaction re112" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re112_s85" id="kmc_re112_s85" name="Michaelis constant of species NFkB in reaction re112" value="1" units="substance"/>
<parameter metaid="vmar_re112" id="vmar_re112" name="Revere maximal velocity of reaction re112" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re112_s3" id="kmc_re112_s3" name="Michaelis constant of species IL-12 in reaction re112" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re75" id="re113" name="re113" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re113</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s97" alias="sa15">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4770610371240225,-0.1718487282820469 0.4770610371240225,-0.1718487282820469</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00242" species="s97">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00243" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00111">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re113 </ci>
<ci> kmc_re113_s97 </ci>
</apply>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re113 </ci>
<ci> kmc_re113_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s97 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re113_s97 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re113_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re113" id="vmaf_re113" name="Forward maximal velocity of reaction re113" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re113_s97" id="kmc_re113_s97" name="Michaelis constant of species TLR in reaction re113" value="1" units="substance"/>
<parameter metaid="vmar_re113" id="vmar_re113" name="Revere maximal velocity of reaction re113" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re113_s85" id="kmc_re113_s85" name="Michaelis constant of species NFkB in reaction re113" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re78" id="re114" name="re114" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re114</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s1" alias="sa14">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s6" alias="sa19">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.47576895257121343,-0.1339854648158996 0.47576895257121343,-0.1339854648158996</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00244" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00245" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00112">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re114 </ci>
<ci> kmc_re114_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re114 </ci>
<ci> kmc_re114_s6 </ci>
</apply>
<ci> s6 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re114_s1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re114_s6 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re114" id="vmaf_re114" name="Forward maximal velocity of reaction re114" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re114_s1" id="kmc_re114_s1" name="Michaelis constant of species Degradation in reaction re114" value="1" units="substance"/>
<parameter metaid="vmar_re114" id="vmar_re114" name="Revere maximal velocity of reaction re114" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re114_s6" id="kmc_re114_s6" name="Michaelis constant of species ROS in reaction re114" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re79" id="re115" name="re115" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re115</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s6" alias="sa19">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5011996652097093,-0.08529712638333464 0.5011996652097093,-0.08529712638333464</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00246" species="s6">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa19</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00247" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00113">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re115 </ci>
<ci> kmc_re115_s6 </ci>
</apply>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re115 </ci>
<ci> kmc_re115_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s6 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re115_s6 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re115_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re115" id="vmaf_re115" name="Forward maximal velocity of reaction re115" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re115_s6" id="kmc_re115_s6" name="Michaelis constant of species ROS in reaction re115" value="1" units="substance"/>
<parameter metaid="vmar_re115" id="vmar_re115" name="Revere maximal velocity of reaction re115" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re115_s85" id="kmc_re115_s85" name="Michaelis constant of species NFkB in reaction re115" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re139" id="re116" name="re116" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re116</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa11">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6483859618260177,-0.04490280587562623 0.6483859618260177,-0.04490280587562623</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00248" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00249" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00114">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re116 </ci>
<ci> kmc_re116_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re116 </ci>
<ci> kmc_re116_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re116_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re116_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re116" id="vmaf_re116" name="Forward maximal velocity of reaction re116" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re116_s86" id="kmc_re116_s86" name="Michaelis constant of species T cells in reaction re116" value="1" units="substance"/>
<parameter metaid="vmar_re116" id="vmar_re116" name="Revere maximal velocity of reaction re116" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re116_s94" id="kmc_re116_s94" name="Michaelis constant of species MCP-1 in reaction re116" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re140" id="re117" name="re117" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re117</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s86" alias="sa5">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s102" alias="sa20">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.590992976174081,0.027599504200523484 0.590992976174081,0.027599504200523484</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00250" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00251" species="s102">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa20</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00115">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re117 </ci>
<ci> kmc_re117_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re117 </ci>
<ci> kmc_re117_s102 </ci>
</apply>
<ci> s102 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re117_s86 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s102 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re117_s102 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re117" id="vmaf_re117" name="Forward maximal velocity of reaction re117" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re117_s86" id="kmc_re117_s86" name="Michaelis constant of species T cells in reaction re117" value="1" units="substance"/>
<parameter metaid="vmar_re117" id="vmar_re117" name="Revere maximal velocity of reaction re117" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re117_s102" id="kmc_re117_s102" name="Michaelis constant of species IL-21 in reaction re117" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re141" id="re118" name="re118" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re118</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s94" alias="sa11">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6640973630831644,-1.0632860040567955 0.6640973630831644,-1.0632860040567955</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00252" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00253" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00116">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re118 </ci>
<ci> kmc_re118_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re118 </ci>
<ci> kmc_re118_s94 </ci>
</apply>
<ci> s94 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re118_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re118_s94 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re118" id="vmaf_re118" name="Forward maximal velocity of reaction re118" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re118_s85" id="kmc_re118_s85" name="Michaelis constant of species NFkB in reaction re118" value="1" units="substance"/>
<parameter metaid="vmar_re118" id="vmar_re118" name="Revere maximal velocity of reaction re118" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re118_s94" id="kmc_re118_s94" name="Michaelis constant of species MCP-1 in reaction re118" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re142" id="re119" name="re119" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re119</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s85" alias="sa16">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s101" alias="sa13">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6102997694081475,-0.37528823981552684 0.6102997694081475,-0.37528823981552684</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00254" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00255" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00117">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re119 </ci>
<ci> kmc_re119_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re119 </ci>
<ci> kmc_re119_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re119_s85 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re119_s101 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re119" id="vmaf_re119" name="Forward maximal velocity of reaction re119" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re119_s85" id="kmc_re119_s85" name="Michaelis constant of species NFkB in reaction re119" value="1" units="substance"/>
<parameter metaid="vmar_re119" id="vmar_re119" name="Revere maximal velocity of reaction re119" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re119_s101" id="kmc_re119_s101" name="Michaelis constant of species IL-18 in reaction re119" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re143" id="re120" name="re120" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re120</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa3">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6726787220088077,0.05560760798276054 0.6726787220088077,0.05560760798276054</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00256" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00257" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00118">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re120 </ci>
<ci> kmc_re120_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re120 </ci>
<ci> kmc_re120_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re120_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re120_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re120" id="vmaf_re120" name="Forward maximal velocity of reaction re120" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re120_s35" id="kmc_re120_s35" name="Michaelis constant of species TNFα in reaction re120" value="1" units="substance"/>
<parameter metaid="vmar_re120" id="vmar_re120" name="Revere maximal velocity of reaction re120" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re120_s85" id="kmc_re120_s85" name="Michaelis constant of species NFkB in reaction re120" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re144" id="re121" name="re121" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re121</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s33" alias="sa1">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.36972425436128287,-0.46370287000562804 0.36972425436128287,-0.46370287000562804</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00258" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00259" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00119">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re121 </ci>
<ci> kmc_re121_s33 </ci>
</apply>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re121 </ci>
<ci> kmc_re121_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re121_s33 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re121_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re121" id="vmaf_re121" name="Forward maximal velocity of reaction re121" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re121_s33" id="kmc_re121_s33" name="Michaelis constant of species IL-1β in reaction re121" value="1" units="substance"/>
<parameter metaid="vmar_re121" id="vmar_re121" name="Revere maximal velocity of reaction re121" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re121_s85" id="kmc_re121_s85" name="Michaelis constant of species NFkB in reaction re121" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re146" id="re123" name="re123" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re123</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa21">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa17">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.676190476190476,-0.2666666666666666 0.676190476190476,-0.2666666666666666</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00262" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00263" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00121">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re123 </ci>
<ci> kmc_re123_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re123 </ci>
<ci> kmc_re123_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re123_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re123_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re123" id="vmaf_re123" name="Forward maximal velocity of reaction re123" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re123_s103" id="kmc_re123_s103" name="Michaelis constant of species NK cells in reaction re123" value="1" units="substance"/>
<parameter metaid="vmar_re123" id="vmar_re123" name="Revere maximal velocity of reaction re123" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re123_s2" id="kmc_re123_s2" name="Michaelis constant of species Dendritic cells in reaction re123" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re147" id="re124" name="re124" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re124</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa21">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa6">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5134918972444917,-0.21408032296764556 0.5134918972444917,-0.21408032296764556</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00264" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00265" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00122">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re124 </ci>
<ci> kmc_re124_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re124 </ci>
<ci> kmc_re124_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re124_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re124_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re124" id="vmaf_re124" name="Forward maximal velocity of reaction re124" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re124_s103" id="kmc_re124_s103" name="Michaelis constant of species NK cells in reaction re124" value="1" units="substance"/>
<parameter metaid="vmar_re124" id="vmar_re124" name="Revere maximal velocity of reaction re124" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re124_s87" id="kmc_re124_s87" name="Michaelis constant of species Macrophage in reaction re124" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re148" id="re125" name="re125" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re125</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa21">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa5">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.28538852832836525,0.8745834064199265 0.28538852832836525,0.8745834064199265</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00266" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00267" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00123">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re125 </ci>
<ci> kmc_re125_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re125 </ci>
<ci> kmc_re125_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re125_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re125_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re125" id="vmaf_re125" name="Forward maximal velocity of reaction re125" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re125_s103" id="kmc_re125_s103" name="Michaelis constant of species NK cells in reaction re125" value="1" units="substance"/>
<parameter metaid="vmar_re125" id="vmar_re125" name="Revere maximal velocity of reaction re125" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re125_s86" id="kmc_re125_s86" name="Michaelis constant of species T cells in reaction re125" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re149" id="re126" name="re126" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re126</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s3" alias="sa18">
<celldesigner:linkAnchor position="NE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa21">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5116123766416858,0.08202864138903365 0.5116123766416858,0.08202864138903365</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00268" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00269" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00124">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re126 </ci>
<ci> kmc_re126_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re126 </ci>
<ci> kmc_re126_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re126_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re126_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re126" id="vmaf_re126" name="Forward maximal velocity of reaction re126" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re126_s3" id="kmc_re126_s3" name="Michaelis constant of species IL-12 in reaction re126" value="1" units="substance"/>
<parameter metaid="vmar_re126" id="vmar_re126" name="Revere maximal velocity of reaction re126" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re126_s103" id="kmc_re126_s103" name="Michaelis constant of species NK cells in reaction re126" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re150" id="re127" name="re127" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re127</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s101" alias="sa13">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa21">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5540432345876685,-0.3847077662129723 0.5540432345876685,-0.3847077662129723</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00270" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00271" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00125">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re127 </ci>
<ci> kmc_re127_s101 </ci>
</apply>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re127 </ci>
<ci> kmc_re127_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re127_s101 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re127_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re127" id="vmaf_re127" name="Forward maximal velocity of reaction re127" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re127_s101" id="kmc_re127_s101" name="Michaelis constant of species IL-18 in reaction re127" value="1" units="substance"/>
<parameter metaid="vmar_re127" id="vmar_re127" name="Revere maximal velocity of reaction re127" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re127_s103" id="kmc_re127_s103" name="Michaelis constant of species NK cells in reaction re127" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re151" id="re128" name="re128" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re128</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s93" alias="sa10">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s103" alias="sa21">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00273" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00126">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re128 </ci>
<ci> kmc_re128_s93 </ci>
</apply>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re128 </ci>
<ci> kmc_re128_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re128_s93 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re128_s103 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re128" id="vmaf_re128" name="Forward maximal velocity of reaction re128" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re128_s93" id="kmc_re128_s93" name="Michaelis constant of species IL-2 in reaction re128" value="1" units="substance"/>
<parameter metaid="vmar_re128" id="vmar_re128" name="Revere maximal velocity of reaction re128" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re128_s103" id="kmc_re128_s103" name="Michaelis constant of species NK cells in reaction re128" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re152" id="re129" name="re129" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re129</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s89" alias="sa8">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
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<celldesigner:lineDirection index="1" value="unknown"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00274" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00275" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00127">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re129 </ci>
<ci> kmc_re129_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re129 </ci>
<ci> kmc_re129_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re129_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re129_s89 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re129" id="vmaf_re129" name="Forward maximal velocity of reaction re129" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re129_s103" id="kmc_re129_s103" name="Michaelis constant of species NK cells in reaction re129" value="1" units="substance"/>
<parameter metaid="vmar_re129" id="vmar_re129" name="Revere maximal velocity of reaction re129" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re129_s89" id="kmc_re129_s89" name="Michaelis constant of species IFNγ  in reaction re129" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re153" id="re130" name="re130" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re130</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa8">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa6">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.45769881556683556,-0.2411167512690362 0.45769881556683556,-0.2411167512690362</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00276" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00277" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00128">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re130 </ci>
<ci> kmc_re130_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re130 </ci>
<ci> kmc_re130_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re130_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re130_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re130" id="vmaf_re130" name="Forward maximal velocity of reaction re130" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re130_s89" id="kmc_re130_s89" name="Michaelis constant of species IFNγ  in reaction re130" value="1" units="substance"/>
<parameter metaid="vmar_re130" id="vmar_re130" name="Revere maximal velocity of reaction re130" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re130_s87" id="kmc_re130_s87" name="Michaelis constant of species Macrophage in reaction re130" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re154" id="re131" name="re131" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re131</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s103" alias="sa21">
<celldesigner:linkAnchor position="WSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s35" alias="sa3">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.12222222222222257,0.0777777777777775 0.12222222222222257,0.0777777777777775</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00278" species="s103">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa21</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00279" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00129">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re131 </ci>
<ci> kmc_re131_s103 </ci>
</apply>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re131 </ci>
<ci> kmc_re131_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s103 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re131_s103 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re131_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re131" id="vmaf_re131" name="Forward maximal velocity of reaction re131" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re131_s103" id="kmc_re131_s103" name="Michaelis constant of species NK cells in reaction re131" value="1" units="substance"/>
<parameter metaid="vmar_re131" id="vmar_re131" name="Revere maximal velocity of reaction re131" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re131_s35" id="kmc_re131_s35" name="Michaelis constant of species TNFα in reaction re131" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re155" id="re132" name="re132" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re132</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s35" alias="sa3">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s87" alias="sa6">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.5309318715740012,0.00469851213782313 0.5309318715740012,0.00469851213782313</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00280" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00281" species="s87">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00130">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re132 </ci>
<ci> kmc_re132_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re132 </ci>
<ci> kmc_re132_s87 </ci>
</apply>
<ci> s87 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re132_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s87 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re132_s87 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re132" id="vmaf_re132" name="Forward maximal velocity of reaction re132" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re132_s35" id="kmc_re132_s35" name="Michaelis constant of species TNFα in reaction re132" value="1" units="substance"/>
<parameter metaid="vmar_re132" id="vmar_re132" name="Revere maximal velocity of reaction re132" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re132_s87" id="kmc_re132_s87" name="Michaelis constant of species Macrophage in reaction re132" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re156" id="re133" name="re133" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re133</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa8">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s2" alias="sa17">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6795131845841791,-0.31643002028397493 0.6795131845841791,-0.31643002028397493</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00282" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00283" species="s2">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00131">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re133 </ci>
<ci> kmc_re133_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re133 </ci>
<ci> kmc_re133_s2 </ci>
</apply>
<ci> s2 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re133_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s2 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re133_s2 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re133" id="vmaf_re133" name="Forward maximal velocity of reaction re133" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re133_s89" id="kmc_re133_s89" name="Michaelis constant of species IFNγ  in reaction re133" value="1" units="substance"/>
<parameter metaid="vmar_re133" id="vmar_re133" name="Revere maximal velocity of reaction re133" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re133_s2" id="kmc_re133_s2" name="Michaelis constant of species Dendritic cells in reaction re133" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re157" id="re134" name="re134" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re134</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s89" alias="sa8">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s86" alias="sa5">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.7397670549084854,0.7291181364392685 0.7397670549084854,0.7291181364392685</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00003" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00004" species="s86">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00132">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re134 </ci>
<ci> kmc_re134_s89 </ci>
</apply>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re134 </ci>
<ci> kmc_re134_s86 </ci>
</apply>
<ci> s86 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re134_s89 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s86 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re134_s86 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re134" id="vmaf_re134" name="Forward maximal velocity of reaction re134" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re134_s89" id="kmc_re134_s89" name="Michaelis constant of species IFNγ  in reaction re134" value="1" units="substance"/>
<parameter metaid="vmar_re134" id="vmar_re134" name="Revere maximal velocity of reaction re134" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re134_s86" id="kmc_re134_s86" name="Michaelis constant of species T cells in reaction re134" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re170" id="re142" name="re142" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re142</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s104" alias="sa22">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.396279639140964,0.03262634058067454 0.396279639140964,0.03262634058067454</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00304" species="s104">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00305" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00137">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re142 </ci>
<ci> kmc_re142_s104 </ci>
</apply>
<ci> s104 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re142 </ci>
<ci> kmc_re142_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s104 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re142_s104 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re142_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re142" id="vmaf_re142" name="Forward maximal velocity of reaction re142" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re142_s104" id="kmc_re142_s104" name="Michaelis constant of species PPRs in reaction re142" value="1" units="substance"/>
<parameter metaid="vmar_re142" id="vmar_re142" name="Revere maximal velocity of reaction re142" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re142_s85" id="kmc_re142_s85" name="Michaelis constant of species NFkB in reaction re142" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re178" id="re143" name="re143" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re143</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa2">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6062096526283431,0.05635823342555479 0.6062096526283431,0.05635823342555479</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00306" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00307" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00138">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re143 </ci>
<ci> kmc_re143_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re143 </ci>
<ci> kmc_re143_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re143_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re143_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re143" id="vmaf_re143" name="Forward maximal velocity of reaction re143" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re143_s34" id="kmc_re143_s34" name="Michaelis constant of species IL-6 in reaction re143" value="1" units="substance"/>
<parameter metaid="vmar_re143" id="vmar_re143" name="Revere maximal velocity of reaction re143" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re143_s85" id="kmc_re143_s85" name="Michaelis constant of species NFkB in reaction re143" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re76" id="re144" name="re144" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re144</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="sa2">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s90" alias="sa9">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
<celldesigner:reactantLink reactant="s89" alias="sa8" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="W"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s35" alias="sa3" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="NNW"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s33" alias="sa1" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="NNE"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s3" alias="sa18" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="NNW"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s93" alias="sa10" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="S"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s101" alias="sa13" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="SE"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
<celldesigner:reactantLink reactant="s94" alias="sa11" targetLineIndex="-1,0">
<celldesigner:linkAnchor position="E"/>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.16687031223565185,-0.05876271218301765 0.16687031223565185,-0.05876271218301765</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00308" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00309" species="s89">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00310" species="s35">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00311" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00312" species="s3">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00313" species="s93">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00314" species="s101">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00315" species="s94">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00316" species="s90">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00139">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci> vmaf_re144 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s34 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s89 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s35 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s33 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s3 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s93 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s101 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s94 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> vmar_re144 </ci>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s90 </ci>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s34 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s89 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s89 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s35 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s33 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s33 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s3 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s93 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s93 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s101 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s101 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s94 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s94 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re144_s90 </ci>
</apply>
</apply>
<ci> hco_re144 </ci>
</apply>
</apply>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re144" id="vmaf_re144" name="Forward maximal velocity of reaction re144" value="1" units="mole_per_second"/>
<parameter metaid="hco_re144" id="hco_re144" name="Reaction cooperativity" value="1" units="dimensionless"/>
<parameter metaid="kmc_re144_s34" id="kmc_re144_s34" name="Michaelis constant of species IL-6 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s89" id="kmc_re144_s89" name="Michaelis constant of species IFNγ  in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s35" id="kmc_re144_s35" name="Michaelis constant of species TNFα in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s33" id="kmc_re144_s33" name="Michaelis constant of species IL-1β in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s3" id="kmc_re144_s3" name="Michaelis constant of species IL-12 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s93" id="kmc_re144_s93" name="Michaelis constant of species IL-2 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s101" id="kmc_re144_s101" name="Michaelis constant of species IL-18 in reaction re144" value="1" units="substance"/>
<parameter metaid="kmc_re144_s94" id="kmc_re144_s94" name="Michaelis constant of species MCP-1 in reaction re144" value="1" units="substance"/>
<parameter metaid="vmar_re144" id="vmar_re144" name="Revere maximal velocity of reaction re144" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re144_s90" id="kmc_re144_s90" name="Michaelis constant of species Cytokine Storm in reaction re144" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re179" id="re145" name="re145" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re145</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s90" alias="sa9">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s4" alias="sa23">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4398928024502293,-0.04402756508422634 0.4398928024502293,-0.04402756508422634</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00317" species="s90">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00318" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa23</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00140">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re145 </ci>
<ci> kmc_re145_s90 </ci>
</apply>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re145 </ci>
<ci> kmc_re145_s4 </ci>
</apply>
<ci> s4 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s90 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re145_s90 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s4 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re145_s4 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re145" id="vmaf_re145" name="Forward maximal velocity of reaction re145" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re145_s90" id="kmc_re145_s90" name="Michaelis constant of species Cytokine Storm in reaction re145" value="1" units="substance"/>
<parameter metaid="vmar_re145" id="vmar_re145" name="Revere maximal velocity of reaction re145" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re145_s4" id="kmc_re145_s4" name="Michaelis constant of species Multi-Organ Failure in reaction re145" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re86" id="re146" name="re146" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re146</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s98" alias="sa24">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s99" alias="sa25">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.38226024313372386,-0.014407924358398105 0.38226024313372386,-0.014407924358398105</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00319" species="s98">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa24</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00320" species="s99">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00141">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re146 </ci>
<ci> kmc_re146_s98 </ci>
</apply>
<ci> s98 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re146 </ci>
<ci> kmc_re146_s99 </ci>
</apply>
<ci> s99 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s98 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re146_s98 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re146_s99 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re146" id="vmaf_re146" name="Forward maximal velocity of reaction re146" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re146_s98" id="kmc_re146_s98" name="Michaelis constant of species PI3K in reaction re146" value="1" units="substance"/>
<parameter metaid="vmar_re146" id="vmar_re146" name="Revere maximal velocity of reaction re146" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re146_s99" id="kmc_re146_s99" name="Michaelis constant of species AKT in reaction re146" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re181" id="re147" name="re147" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:name>re147</celldesigner:name>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s99" alias="sa25">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s85" alias="sa16">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.4326923076923077,-0.004807692307692069 0.4326923076923077,-0.004807692307692069</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00321" species="s99">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa25</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00322" species="s85">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00142">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re147 </ci>
<ci> kmc_re147_s99 </ci>
</apply>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re147 </ci>
<ci> kmc_re147_s85 </ci>
</apply>
<ci> s85 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s99 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re147_s99 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s85 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re147_s85 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re147" id="vmaf_re147" name="Forward maximal velocity of reaction re147" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re147_s99" id="kmc_re147_s99" name="Michaelis constant of species AKT in reaction re147" value="1" units="substance"/>
<parameter metaid="vmar_re147" id="vmar_re147" name="Revere maximal velocity of reaction re147" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re147_s85" id="kmc_re147_s85" name="Michaelis constant of species NFkB in reaction re147" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>