<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model metaid="untitled" id="untitled">
<annotation/>
<listOfUnitDefinitions>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00058" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00059" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00060" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00061" kind="metre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00062" kind="second"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="mole_per_second" id="mole_per_second" name="mole per second">
<listOfUnits>
<unit metaid="CDMT00088" kind="mole">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00088">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.unit:UO%3A0000013"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</unit>
<unit metaid="CDMT00089" kind="second" exponent="-1">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#CDMT00089">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:obo.unit:UO%3A0000010"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</unit>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="default" id="default" size="1" units="volume"/>
</listOfCompartments>
<listOfSpecies>
<species metaid="s46" id="s46" name="Insulin" compartment="default" initialAmount="1.53" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s47" id="s47" name="Insulin Receptor" compartment="default" initialAmount="1.53" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s34" id="s34" name="IL-6" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s35" id="s35" name="TNFα" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s32" id="s32" name="Inflammation" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s81" id="s81" name="P38" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s82" id="s82" name="PTEN" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s69" id="s69" name="IRS-1" compartment="default" initialAmount="1.66" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s12" id="s12" name="IRS-1" compartment="default" initialAmount="1.66" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s37" id="s37" name="Oxidative stress" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s36" id="s36" name="ROS" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s74" id="s74" name="Cell death" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s57" id="s57" name="AKT" compartment="default" initialAmount="1.4" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s56" id="s56" name="PI3K" compartment="default" initialAmount="1.36" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s55" id="s55" name="IRS1" compartment="default" initialAmount="1.36" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s75" id="s75" name="Glucose uptake" compartment="default" initialAmount="1.4" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s71" id="s71" name="JNK" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s72" id="s72" name="JNK" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s1" id="s1" name="NO" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s3" id="s3" name="Infection" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
<species metaid="s83" id="s83" name="iNOS" compartment="default" initialAmount="0" substanceUnits="substance" charge="0">
<annotation/>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re57" id="re2" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00006" species="s32"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00007" species="s34"/>
</listOfProducts>
<kineticLaw metaid="CDMT00092">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re2 </ci>
<ci> kmc_re2_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re2 </ci>
<ci> kmc_re2_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re2_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re2" id="vmaf_re2" name="Forward maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s32" id="kmc_re2_s32" name="Michaelis constant of species Inflammation in reaction re2" value="1" units="substance"/>
<parameter metaid="vmar_re2" id="vmar_re2" name="Revere maximal velocity of reaction re2" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re2_s34" id="kmc_re2_s34" name="Michaelis constant of species IL-6 in reaction re2" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re58" id="re3" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00008" species="s32"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00009" species="s35"/>
</listOfProducts>
<kineticLaw metaid="CDMT00093">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re3 </ci>
<ci> kmc_re3_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re3 </ci>
<ci> kmc_re3_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re3_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re3" id="vmaf_re3" name="Forward maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s32" id="kmc_re3_s32" name="Michaelis constant of species Inflammation in reaction re3" value="1" units="substance"/>
<parameter metaid="vmar_re3" id="vmar_re3" name="Revere maximal velocity of reaction re3" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re3_s35" id="kmc_re3_s35" name="Michaelis constant of species TNFα in reaction re3" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re59" id="re4" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00010" species="s32"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00011" species="s36"/>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re4 </ci>
<ci> kmc_re4_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re4 </ci>
<ci> kmc_re4_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s32 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re4_s36 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re4" id="vmaf_re4" name="Forward maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s32" id="kmc_re4_s32" name="Michaelis constant of species Inflammation in reaction re4" value="1" units="substance"/>
<parameter metaid="vmar_re4" id="vmar_re4" name="Revere maximal velocity of reaction re4" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re4_s36" id="kmc_re4_s36" name="Michaelis constant of species ROS in reaction re4" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re60" id="re5" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00012" species="s36"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00013" species="s37"/>
</listOfProducts>
<kineticLaw metaid="CDMT00095">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re5 </ci>
<ci> kmc_re5_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re5 </ci>
<ci> kmc_re5_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re5_s37 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re5" id="vmaf_re5" name="Forward maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s36" id="kmc_re5_s36" name="Michaelis constant of species ROS in reaction re5" value="1" units="substance"/>
<parameter metaid="vmar_re5" id="vmar_re5" name="Revere maximal velocity of reaction re5" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re5_s37" id="kmc_re5_s37" name="Michaelis constant of species Oxidative stress in reaction re5" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re83" id="re6" reversible="false" fast="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00014" species="s47"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00015" species="s46"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00016" species="s46"/>
<modifierSpeciesReference metaid="CDMT00017" species="s32"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00096">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re6 </ci>
<ci> kmc_re6_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re6 </ci>
<ci> kmc_re6_s46 </ci>
</apply>
<ci> s46 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re6_s32 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s47 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s46 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re6_s46 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re6_s32 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re6" id="vmaf_re6" name="Forward maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s47" id="kmc_re6_s47" name="Michaelis constant of species Insulin Receptor in reaction re6" value="1" units="substance"/>
<parameter metaid="vmar_re6" id="vmar_re6" name="Revere maximal velocity of reaction re6" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re6_s46" id="kmc_re6_s46" name="Michaelis constant of species Insulin in reaction re6" value="1" units="substance"/>
<parameter metaid="kic_1_re6_s32" id="kic_1_re6_s32" name="Inhibitory constant for species Inflammationwith 1 binding positions of reaction re6" value="1" units="substance"/>
<parameter metaid="kic_2_re6_s32" id="kic_2_re6_s32" name="Inhibitory constant for species Inflammationwith 2 binding positions of reaction re6" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re84" id="re7" reversible="false" fast="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00018" species="s47"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00019" species="s55"/>
</listOfProducts>
<kineticLaw metaid="CDMT00097">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re7 </ci>
<ci> kmc_re7_s47 </ci>
</apply>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re7 </ci>
<ci> kmc_re7_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s47 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s47 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re7_s55 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re7" id="vmaf_re7" name="Forward maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s47" id="kmc_re7_s47" name="Michaelis constant of species Insulin Receptor in reaction re7" value="1" units="substance"/>
<parameter metaid="vmar_re7" id="vmar_re7" name="Revere maximal velocity of reaction re7" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re7_s55" id="kmc_re7_s55" name="Michaelis constant of species IRS1 in reaction re7" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re85" id="re8" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00020" species="s55"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00021" species="s56"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00047" species="s1"/>
<modifierSpeciesReference metaid="CDMT00050" species="s72"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00098">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re8_s1 </ci>
<apply>
<plus/>
<ci> kic_re8_s1 </ci>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re8_s72 </ci>
<apply>
<plus/>
<ci> kic_re8_s72 </ci>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re8 </ci>
<ci> kmc_re8_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re8 </ci>
<ci> kmc_re8_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s55 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re8_s56 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re8" id="vmaf_re8" name="Forward maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s55" id="kmc_re8_s55" name="Michaelis constant of species IRS1 in reaction re8" value="1" units="substance"/>
<parameter metaid="vmar_re8" id="vmar_re8" name="Revere maximal velocity of reaction re8" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re8_s56" id="kmc_re8_s56" name="Michaelis constant of species PI3K in reaction re8" value="1" units="substance"/>
<parameter metaid="kic_re8_s1" id="kic_re8_s1" name="Inhibitory constant for species NO of reaction re8" value="1" units="substance"/>
<parameter metaid="kic_re8_s72" id="kic_re8_s72" name="Inhibitory constant for species JNK of reaction re8" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re86" id="re9" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00022" species="s56"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00023" species="s57"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00024" species="s34"/>
<modifierSpeciesReference metaid="CDMT00025" species="s82"/>
<modifierSpeciesReference metaid="CDMT00048" species="s1"/>
<modifierSpeciesReference metaid="CDMT00054" species="s36"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re9_s34 </ci>
<apply>
<plus/>
<ci> kic_re9_s34 </ci>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<ci> kic_re9_s36 </ci>
</apply>
<apply>
<plus/>
<ci> kic_re9_s36 </ci>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<ci> kic_re9_s82 </ci>
</apply>
<apply>
<plus/>
<ci> kic_re9_s82 </ci>
<apply>
<times/>
<ci> s82 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re9_s1 </ci>
<apply>
<plus/>
<ci> kic_re9_s1 </ci>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re9 </ci>
<ci> kmc_re9_s56 </ci>
</apply>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re9 </ci>
<ci> kmc_re9_s57 </ci>
</apply>
<ci> s57 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s56 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s56 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re9_s57 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re9" id="vmaf_re9" name="Forward maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s56" id="kmc_re9_s56" name="Michaelis constant of species PI3K in reaction re9" value="1" units="substance"/>
<parameter metaid="vmar_re9" id="vmar_re9" name="Revere maximal velocity of reaction re9" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re9_s57" id="kmc_re9_s57" name="Michaelis constant of species AKT in reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s34" id="kic_re9_s34" name="Inhibitory constant for species IL-6 of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s82" id="kic_re9_s82" name="Inhibitory constant for species PTEN of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s1" id="kic_re9_s1" name="Inhibitory constant for species NO of reaction re9" value="1" units="substance"/>
<parameter metaid="kic_re9_s36" id="kic_re9_s36" name="Inhibitory constant for species ROS of reaction re9" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re68" id="re10" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00026" species="s12"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00027" species="s69"/>
</listOfProducts>
<kineticLaw metaid="CDMT00100">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re10 </ci>
<ci> kmc_re10_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re10 </ci>
<ci> kmc_re10_s69 </ci>
</apply>
<ci> s69 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s12 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s69 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re10_s69 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re10" id="vmaf_re10" name="Forward maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s12" id="kmc_re10_s12" name="Michaelis constant of species IRS-1 in reaction re10" value="1" units="substance"/>
<parameter metaid="vmar_re10" id="vmar_re10" name="Revere maximal velocity of reaction re10" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re10_s69" id="kmc_re10_s69" name="Michaelis constant of species IRS-1 in reaction re10" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re69" id="re11" reversible="false" fast="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00028" species="s55"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00029" species="s12"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00049" species="s1"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00101">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re11 </ci>
<ci> kmc_re11_s55 </ci>
</apply>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re11 </ci>
<ci> kmc_re11_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re11_s1 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s55 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s55 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re11_s12 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re11_s1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re11" id="vmaf_re11" name="Forward maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s55" id="kmc_re11_s55" name="Michaelis constant of species IRS1 in reaction re11" value="1" units="substance"/>
<parameter metaid="vmar_re11" id="vmar_re11" name="Revere maximal velocity of reaction re11" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re11_s12" id="kmc_re11_s12" name="Michaelis constant of species IRS-1 in reaction re11" value="1" units="substance"/>
<parameter metaid="kic_1_re11_s1" id="kic_1_re11_s1" name="Inhibitory constant for species NOwith 1 binding positions of reaction re11" value="1" units="substance"/>
<parameter metaid="kic_2_re11_s1" id="kic_2_re11_s1" name="Inhibitory constant for species NOwith 2 binding positions of reaction re11" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re100" id="re12" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00030" species="s35"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00031" species="s12"/>
</listOfProducts>
<kineticLaw metaid="CDMT00102">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re12 </ci>
<ci> kmc_re12_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re12 </ci>
<ci> kmc_re12_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re12_s12 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re12" id="vmaf_re12" name="Forward maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s35" id="kmc_re12_s35" name="Michaelis constant of species TNFα in reaction re12" value="1" units="substance"/>
<parameter metaid="vmar_re12" id="vmar_re12" name="Revere maximal velocity of reaction re12" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re12_s12" id="kmc_re12_s12" name="Michaelis constant of species IRS-1 in reaction re12" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re101" id="re13" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00032" species="s34"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00033" species="s12"/>
</listOfProducts>
<kineticLaw metaid="CDMT00103">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re13 </ci>
<ci> kmc_re13_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re13 </ci>
<ci> kmc_re13_s12 </ci>
</apply>
<ci> s12 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s34 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s12 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re13_s12 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re13" id="vmaf_re13" name="Forward maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s34" id="kmc_re13_s34" name="Michaelis constant of species IL-6 in reaction re13" value="1" units="substance"/>
<parameter metaid="vmar_re13" id="vmar_re13" name="Revere maximal velocity of reaction re13" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re13_s12" id="kmc_re13_s12" name="Michaelis constant of species IRS-1 in reaction re13" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re102" id="re14" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00034" species="s37"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00035" species="s74"/>
</listOfProducts>
<kineticLaw metaid="CDMT00104">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re14 </ci>
<ci> kmc_re14_s37 </ci>
</apply>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re14 </ci>
<ci> kmc_re14_s74 </ci>
</apply>
<ci> s74 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s37 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s37 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s74 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re14_s74 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re14" id="vmaf_re14" name="Forward maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s37" id="kmc_re14_s37" name="Michaelis constant of species Oxidative stress in reaction re14" value="1" units="substance"/>
<parameter metaid="vmar_re14" id="vmar_re14" name="Revere maximal velocity of reaction re14" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re14_s74" id="kmc_re14_s74" name="Michaelis constant of species Cell death in reaction re14" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re103" id="re15" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00036" species="s57"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s75"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00038" species="s36"/>
<modifierSpeciesReference metaid="CDMT00053" species="s72"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00105">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<divide/>
<ci> kic_re15_s36 </ci>
<apply>
<plus/>
<ci> kic_re15_s36 </ci>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci> kic_re15_s72 </ci>
<apply>
<plus/>
<ci> kic_re15_s72 </ci>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re15 </ci>
<ci> kmc_re15_s57 </ci>
</apply>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re15 </ci>
<ci> kmc_re15_s75 </ci>
</apply>
<ci> s75 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s57 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s57 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s75 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re15_s75 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re15" id="vmaf_re15" name="Forward maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s57" id="kmc_re15_s57" name="Michaelis constant of species AKT in reaction re15" value="1" units="substance"/>
<parameter metaid="vmar_re15" id="vmar_re15" name="Revere maximal velocity of reaction re15" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re15_s75" id="kmc_re15_s75" name="Michaelis constant of species Glucose uptake in reaction re15" value="1" units="substance"/>
<parameter metaid="kic_re15_s36" id="kic_re15_s36" name="Inhibitory constant for species ROS of reaction re15" value="1" units="substance"/>
<parameter metaid="kic_re15_s72" id="kic_re15_s72" name="Inhibitory constant for species JNK of reaction re15" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re108" id="re16" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00039" species="s81"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00040" species="s82"/>
</listOfProducts>
<kineticLaw metaid="CDMT00106">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re16 </ci>
<ci> kmc_re16_s81 </ci>
</apply>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re16 </ci>
<ci> kmc_re16_s82 </ci>
</apply>
<ci> s82 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s81 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s82 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re16_s82 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re16" id="vmaf_re16" name="Forward maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s81" id="kmc_re16_s81" name="Michaelis constant of species P38 in reaction re16" value="1" units="substance"/>
<parameter metaid="vmar_re16" id="vmar_re16" name="Revere maximal velocity of reaction re16" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re16_s82" id="kmc_re16_s82" name="Michaelis constant of species PTEN in reaction re16" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re109" id="re17" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00041" species="s36"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00042" species="s81"/>
</listOfProducts>
<kineticLaw metaid="CDMT00107">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re17 </ci>
<ci> kmc_re17_s36 </ci>
</apply>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re17 </ci>
<ci> kmc_re17_s81 </ci>
</apply>
<ci> s81 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s36 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s81 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re17_s81 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re17" id="vmaf_re17" name="Forward maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s36" id="kmc_re17_s36" name="Michaelis constant of species ROS in reaction re17" value="1" units="substance"/>
<parameter metaid="vmar_re17" id="vmar_re17" name="Revere maximal velocity of reaction re17" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re17_s81" id="kmc_re17_s81" name="Michaelis constant of species P38 in reaction re17" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re99" id="re18" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00043" species="s71"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00044" species="s72"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00052" species="s36"/>
</listOfModifiers>
<kineticLaw metaid="CDMT00108">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re18 </ci>
<ci> kmc_re18_s71 </ci>
</apply>
<ci> s71 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re18 </ci>
<ci> kmc_re18_s72 </ci>
</apply>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kic_1_re18_s36 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> s71 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s71 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re18_s72 </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s36 </ci>
<ci> default </ci>
</apply>
<ci> kic_2_re18_s36 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re18" id="vmaf_re18" name="Forward maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s71" id="kmc_re18_s71" name="Michaelis constant of species JNK in reaction re18" value="1" units="substance"/>
<parameter metaid="vmar_re18" id="vmar_re18" name="Revere maximal velocity of reaction re18" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re18_s72" id="kmc_re18_s72" name="Michaelis constant of species JNK in reaction re18" value="1" units="substance"/>
<parameter metaid="kic_1_re18_s36" id="kic_1_re18_s36" name="Inhibitory constant for species ROSwith 1 binding positions of reaction re18" value="1" units="substance"/>
<parameter metaid="kic_2_re18_s36" id="kic_2_re18_s36" name="Inhibitory constant for species ROSwith 2 binding positions of reaction re18" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re19" id="re19" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00045" species="s35"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00046" species="s72"/>
</listOfProducts>
<kineticLaw metaid="CDMT00109">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re19 </ci>
<ci> kmc_re19_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re19 </ci>
<ci> kmc_re19_s72 </ci>
</apply>
<ci> s72 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s72 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re19_s72 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re19" id="vmaf_re19" name="Forward maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s35" id="kmc_re19_s35" name="Michaelis constant of species TNFα in reaction re19" value="1" units="substance"/>
<parameter metaid="vmar_re19" id="vmar_re19" name="Revere maximal velocity of reaction re19" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re19_s72" id="kmc_re19_s72" name="Michaelis constant of species JNK in reaction re19" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re21" id="re21" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00055" species="s3"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00056" species="s32"/>
</listOfProducts>
<kineticLaw metaid="CDMT00110">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re21 </ci>
<ci> kmc_re21_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re21 </ci>
<ci> kmc_re21_s32 </ci>
</apply>
<ci> s32 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s32 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re21_s32 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re21" id="vmaf_re21" name="Forward maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s3" id="kmc_re21_s3" name="Michaelis constant of species Infection in reaction re21" value="1" units="substance"/>
<parameter metaid="vmar_re21" id="vmar_re21" name="Revere maximal velocity of reaction re21" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re21_s32" id="kmc_re21_s32" name="Michaelis constant of species Inflammation in reaction re21" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re22" id="re22" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00051" species="s3"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00057" species="s34"/>
</listOfProducts>
<kineticLaw metaid="CDMT00111">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re22 </ci>
<ci> kmc_re22_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re22 </ci>
<ci> kmc_re22_s34 </ci>
</apply>
<ci> s34 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s34 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re22_s34 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re22" id="vmaf_re22" name="Forward maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s3" id="kmc_re22_s3" name="Michaelis constant of species Infection in reaction re22" value="1" units="substance"/>
<parameter metaid="vmar_re22" id="vmar_re22" name="Revere maximal velocity of reaction re22" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re22_s34" id="kmc_re22_s34" name="Michaelis constant of species IL-6 in reaction re22" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re23" id="re23" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00063" species="s3"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00064" species="s35"/>
</listOfProducts>
<kineticLaw metaid="CDMT00112">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re23 </ci>
<ci> kmc_re23_s3 </ci>
</apply>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re23 </ci>
<ci> kmc_re23_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s3 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s3 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re23_s35 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re23" id="vmaf_re23" name="Forward maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s3" id="kmc_re23_s3" name="Michaelis constant of species Infection in reaction re23" value="1" units="substance"/>
<parameter metaid="vmar_re23" id="vmar_re23" name="Revere maximal velocity of reaction re23" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re23_s35" id="kmc_re23_s35" name="Michaelis constant of species TNFα in reaction re23" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re24" id="re24" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00086" species="s83"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00087" species="s1"/>
</listOfProducts>
<kineticLaw metaid="CDMT00113">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re24 </ci>
<ci> kmc_re24_s83 </ci>
</apply>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re24 </ci>
<ci> kmc_re24_s1 </ci>
</apply>
<ci> s1 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s83 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s1 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re24_s1 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re24" id="vmaf_re24" name="Forward maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s83" id="kmc_re24_s83" name="Michaelis constant of species iNOS in reaction re24" value="1" units="substance"/>
<parameter metaid="vmar_re24" id="vmar_re24" name="Revere maximal velocity of reaction re24" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re24_s1" id="kmc_re24_s1" name="Michaelis constant of species NO in reaction re24" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction metaid="re25" id="re25" reversible="false">
<annotation/>
<listOfReactants>
<speciesReference metaid="CDMT00090" species="s35"/>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00091" species="s83"/>
</listOfProducts>
<kineticLaw metaid="CDMT00114">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<ci> vmaf_re25 </ci>
<ci> kmc_re25_s35 </ci>
</apply>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci> vmar_re25 </ci>
<ci> kmc_re25_s83 </ci>
</apply>
<ci> s83 </ci>
<ci> default </ci>
</apply>
</apply>
<apply>
<plus/>
<cn type="integer"> 1 </cn>
<apply>
<divide/>
<apply>
<times/>
<ci> s35 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s35 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> s83 </ci>
<ci> default </ci>
</apply>
<ci> kmc_re25_s83 </ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters>
<parameter metaid="vmaf_re25" id="vmaf_re25" name="Forward maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s35" id="kmc_re25_s35" name="Michaelis constant of species TNFα in reaction re25" value="1" units="substance"/>
<parameter metaid="vmar_re25" id="vmar_re25" name="Revere maximal velocity of reaction re25" value="1" units="mole_per_second"/>
<parameter metaid="kmc_re25_s83" id="kmc_re25_s83" name="Michaelis constant of species iNOS in reaction re25" value="1" units="substance"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>