# Octopus Neuron Simulation ## Instructions to Run 1. **Install NEURON 8.2 Simulation Environment.** 2. **Compile Mod Files:** - Compile the mod files in the folder into a new `special`. - Alternatively, drag and drop the folder of interest into the `mknrndll` application icon in NEURON. 3. **Run the Simulation:** - Open Terminal and navigate to the directory containing this file. - Execute one of the following commands: - For a full morphologically realistic simulation: ```bash mod/x86_64/special init-octopus-simulation.hoc ``` - For a reduced compartment simulation: ```bash mod/x86_64/special Original_test_octopus_spencer_stick.hoc ``` 4. **Mimic Kv and HCN Block or Control Conditions:** - To mimic Kv and HCN block, set `scl` and `ghf` to `0`. - To mimic control conditions, set `scl` to `1e-1` and `ghf` to `1`. 5. **Tune Conductance:** - Excitatory and inhibitory conductance can be adjusted from the GUI.